| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Outline of Final Research Achievements |
We investigated the impact of maternal vitamin C (VC) content on the growth of fetal mice during the gestation period by using senescence marker protein-30 (SMP30) /gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize VC in vivo. As a results, a diet sufficiently replete with VC is essential during the gestational period for normal tissue development in the fetus and neonate. Moreover, we investigated whether VC-treatment not only prevents but restores smoke-induced emphysema in SMP30/GNL KO mice. As a results, we found that VC-treatment may provide a new therapeutic strategy for chronic obstructive pulmonary disease (COPD) in human.
|
