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Exploring peptide vaccines for infectious diseases of fish

Research Project

Project/Area Number 24380111
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General fisheries
Research InstitutionFisheries Research Agency

Principal Investigator

NAKAMURA Yoji  独立行政法人水産総合研究センター, 中央水産研究所, 主任研究員 (90463182)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Atushi  独立行政法人水産総合研究センター, 中央水産研究所, グループ長 (30443352)
YASUIKE Motoshige  独立行政法人水産総合研究センター, 中央水産研究所, 研究員 (20604820)
NAKAYASU Chihaya  独立行政法人水産総合研究センター, 増養殖研究所, グループ長 (00311225)
MATSUYAMA Tomomasa  独立行政法人水産総合研究センター, 増養殖研究所, 主任研究員 (20372021)
TAKANO Tomokazu  独立行政法人水産総合研究センター, 増養殖研究所, 研究員 (40533998)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords魚病 / 免疫学 / バイオインフォマティクス
Outline of Final Research Achievements

The aim of this study was to design peptide vaccines for infectious diseases of cultured fish, Japanese flounder. Since little is known about the immune system of Japanese flounder at the molecular level, such as haplotypes of major histocompatibility complex (MHC) genes, we inferred the candidates of antigens (i.e. peptide vaccines) by using bioinformatics. In particular, we focused on edwardsiellosis caused by a bacterium, Edwardsiella tarda, surveyed the protein-coding genes, and predicted 11 peptide sequences recognized by MHC of Japanese flounder. After Japanese flounders were inoculated with these peptides, respectively, the infection test by E. tarda was performed. As a result, we found that in three out of 11 peptides the survival rates of Japanese flounder were equal to or larger than that with the positive control treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (3 results)

All 2015 Other

All Presentation (3 results)

  • [Presentation] 魚病細菌Edwardsiella tardaマダイ由来非定型株のゲノム解析2015

    • Author(s)
      中村洋路、西木一生、安池元重、藤原篤志、甲斐渉、高野倫一、坂井貴光、松山知正、中易千早、長井敏、小林敬典、乙竹充
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス
    • Year and Date
      2015-03-27 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒラメの主要組織適合遺伝子複合体のジェノタイピング

    • Author(s)
      中村洋路、安池元重、甲斐渉、藤原篤志
    • Organizer
      NGS現場の会第3回研究会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代シーケンサーを利用したヒラメの主要組織適合遺伝子複合体(MHC)クラスIa遺伝子のジェノタイピング

    • Author(s)
      安池元重、中村洋路、藤原篤志、松山知正、高野倫一、中易千早
    • Organizer
      平成26年度日本水産学会春季大会
    • Place of Presentation
      北海道大学函館キャンパス
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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