Integrated control to improve animal performance under environmental stress conditions: interactions between oxidative stress and metabolic and immunological responses
| Project/Area Number |
24380147
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Tohoku University |
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Principal Investigator |
TOYOMIZU Masaaki 東北大学, (連合)農学研究科(研究院), 教授 (80180199)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kazuaki 山形県立米沢栄養大学, 健康栄養学科, 教授 (80183440)
OHTSU Haruhiko (独)農業, 食品産業技術総合研究機構・畜産草地研究所, 主任研究員 (40455316)
KIKUSATO Motoi 東北大学, 農学研究科, 助教 (90613042)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 暑熱ストレス / 活性酸素種 / タンパク質分解速度 / サイトカイン / ミトコンドリア / LPS（Lipopolysaccharide） / ユビキチンプロテアソームタンパク質分解 / オレウロペイン / アナカルド酸 / 炎症応答 / 活性酸素 / SOD(superoxide dismulase) / CAT(Catalase) / NOX4(NADPH oxidase) / LPS(Lipopolysaccharide) / 炎症性サイトカイン / 3M-His(3メチルヒスチジン) |
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| Outline of Final Research Achievements |
The present study was conducted to investigate the effect of heat stress (HS) and endotoxin stress on redox and metabolic states of broiler chickens. HS induced oxidative stress in skeletal muscle and liver. The anti-oxidant responses in the muscle were observed, but not in the liver. The treatments of birds with lipopolysaccharide did not induce oxidative damages to those tissues, while expression of inflammatory cytokines was enhanced. Then, electrolyzed reduced water and organic selenium were given HS-birds to aim at alleviating the oxidative stress and growth retardation. As results, oxidative stress was basically restored to normal values, whereas the growth in HS conditions was not improved by both treatments. Taken together, these findings suggest that not only regulation of oxidative stress but also optimization of other physiological alteration such as intestinal microbiota may be required in order to suppress the growth retardation due to HS conditions.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Effect of feeding butoxybutyl alcohol on growth performance and status of skeletal muscle proteolysis in broiler chickens2015
Author(s)
Kamizono, T., Saputra, D., Miura, I., Kikusato, M., Hayashi, K. and Toyomizu, M.
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Journal Title
Journal of Agricultural Science
Volume: In press
Issue: 5
Pages: 920-928
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Electrolyzed reduced water ameliorates heat stress-induced oxidative damage to liver, possibly via a deacetylation of superoxide dismutase 22014
Author(s)
Kikusato, M., Matsuno, R., Furukawa, K., Matsueda, T. and Toyomizu, M.
Organizer
17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
Place of Presentation
Sakyou-ku, Kyoto, Japan
Related Report
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