|Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|Outline of Final Research Achievements
生殖内分泌学Prostaglandin (PG)F2α-induced luteolysis is required for the progression of the reproductive cycle and inducing next ovulation. In this study, we tried to clarify the detailed mechanisms of luteolysis to contribute to develop the method of the artificial control of the reproductive cycle. During the stage that corpus luteum (CL) is regressing, galectin-3 expression in CL tissues and testosterone level in the circulation were high. Both factors decreased viability of cultured CL cells. In cultured CL cells, the CL-protective effect of galectin-1 was inhibited by α2,6 sialic acid that concentration was high during the stage that CL was regressing. PGF2α increased the expressions of PGF synthases and the secretion of PGF2α in cultured CL cells, implying the presence of auto-amplification system in CL tissues. Detailed mechanisms of CL regression which has been clarified by this study are expected to contribute to developing the artificial control the reproductive cycle.