| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
MRL/MpJ mouse is known as an autoimmune disease and abnormal spermatogenesis model. In this study, spermatogenetic checkpoint function in the blood testis barrier (BTB) was analyzed by using this mouse.
Claudin3 was located to a spermatocyte at the time of the BTB passage, and the BTB passage was controlled by its expression. As the responsibility gene of testicular oocytes was located to the first chromosome, its relations with the autoimmune disease were doubted. As a result of vitamin A deficiency, the BTB was regarded as structure to take the differentiation adjustment of the spermatogenetic germ cells. It was shown by the heat shock that there were a BTB failure-resistant factor and a calcification remission factor on the chromosomes 1 and 11. Particularly, the telomere domain of MRL chromosome 1 is important, and the identification of the candidate gene is interested in future.
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