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Identification of energy sensors mediating suppression of reproductive functions under malnutrition

Research Project

Project/Area Number 24380157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

Maeda Kei-ichiro  東京大学, 農学生命科学研究科, 教授 (30181580)

Co-Investigator(Kenkyū-buntansha) 平林 真澄  生理学研究所, 行動・代謝分子解析センター, 准教授 (20353435)
Research Collaborator 美辺 詩織  
松田 二子  
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords上位細胞 / 栄養 / 繁殖 / 上衣細胞 / 遺伝改変動物 / エネルギーセンシング / 細胞内カルシウム測定 / エネルギー / 低栄養 / グルコース / AMPキナーゼ / 生殖 / 摂食 / ケトン体
Outline of Final Research Achievements

In lactating cows, gonadal functions are suppressed because of the malnutrition caused by a big milk yield. The suppression is probably due to a decrease in energy levels. Hindbrain ependymocyte is a candidate for energy sensor involved in the suppression of gonadal activities through suppressing gonadotropin secretion in rats. We aimed to get evidence for ependymocytes to sense glucose levels through AMP kinase which is considered to be a energy-sensing molecule in various kinds of cells. In addition, a neural pathway relaying information on the energy level from ependymocytes to the hypothalamic neurons controlling reproduction. As a result, ependymocytes senses extracellular glucose levels through an AMP kinase-mediated mechanism. In addition, the information on energy level might be transmitted from ependymocytes to neurons located in the hypothalamic paraventricular nucleus. The present result would contribute to treatments of reproductive disorders in lactating cows.

Report

(4 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents.2015

    • Author(s)
      Minabe, S., Deura, C., Ikegami, K., Goto, T., Sanbo, M., Hirabayashi, M., Inoue, N., Uenoyama, Y., Maeda, K., Tsukamura, H.
    • Journal Title

      Endocrinology

      Volume: in press Issue: 6 Pages: 2278-2287

    • DOI

      10.1210/en.2014-2018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 新たな中枢性繁殖制御剤のシーズ:KNDyニューロン2014

    • Author(s)
      前多敬一郎、大石真也、束 村博 子、上野山 賀 久、大 蔵聡、松 田二 子
    • Journal Title

      MPアグロジャーナル

      Volume: 26.1 Pages: 17-21

    • NAID

      40020266615

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Dynorphin-Kappa Opioid Receptor Signaling Partly Mediates Estrogen Negative Feedback Effect on LH Pulses in Female Rats2013

    • Author(s)
      Mostari MP, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda KI, Tsukamura H.
    • Journal Title

      Journal of Reproduction and Development

      Volume: 59 Issue: 3 Pages: 266-272

    • DOI

      10.1262/jrd.2012-193

    • NAID

      10031184756

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminisation of luteinising hormone surge and lordosis capacity in therat.2013

    • Author(s)
      Sakakibara, M., Deura, C., Minabe, S., Iwata, K, Uenoyama, Y, Maeda, K.-I., Tsukanura, H.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 25 Pages: 251-259

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminisation of luteinising hormone surge and lordosis capacity in the rat.2012

    • Author(s)
      榊原基嗣
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 25 Issue: 3 Pages: 251-259

    • DOI

      10.1111/j.1365-2826.2012.02389.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oestrogen-dependent suppression of pulsatile luteinising hormone secretion and kissl mRNA expression in the arcuate nucleus during late lactation in rats.2012

    • Author(s)
      山田俊児
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 24 Issue: 9 Pages: 1234-1242

    • DOI

      10.1111/j.1365-2826.2012.02330.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of Kissl gene expression mediating estrogen-positive feedback action in the mouse brain.2012

    • Author(s)
      富川順子
    • Journal Title

      Proceedings of the National Academy of Sciences USA (PNAS)

      Volume: 109 Issue: 20 Pages: 1294-1301

    • DOI

      10.1073/pnas.1114245109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 性腺機能制御に関わる後脳上衣細胞の AMP 活性化プロテインキナーゼ(AMPK) の役割2014

    • Author(s)
      美辺詩織、松本華代、出浦慎哉、池上花奈、後藤哲平、三宝誠、 平林真澄、上野山賀久、前多敬一郎 、束村博子
    • Organizer
      下垂体研究会
    • Place of Presentation
      八王子セミナーハウス
    • Year and Date
      2014-08-08 – 2014-08-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 後脳上衣細胞可視化マウスの作製2013

    • Author(s)
      美辺詩織、林真弓、後藤哲平、三宝誠、平林真澄、上野山賀久、前多敬一 郎、束村博子
    • Organizer
      第106回 日本繁殖生物学会大会
    • Place of Presentation
      東京農工大学農学部府中キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Energetic regulation of reproduction: an energy sensor in the brain2013

    • Author(s)
      Kei-ichiro Maeda
    • Organizer
      Recent advances in the central control of reproduction
    • Place of Presentation
      Centre INRA Val de Loire, 37380 Nouzilly, Conference hall, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Kisspeptin Signaling in Reproductive Biology2013

    • Author(s)
      Okamura, H., Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y. and Maeda, K.-I.
    • Total Pages
      514
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Kisspeptin Signaling in Reproductive Biology2013

    • Author(s)
      Okaraura, H. , Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y. and Maeda, K. I.
    • Total Pages
      454
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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