Identification of energy sensors mediating suppression of reproductive functions under malnutrition
| Project/Area Number |
24380157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
平林 真澄 生理学研究所, 行動・代謝分子解析センター, 准教授 (20353435)
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| Research Collaborator |
美辺 詩織
松田 二子
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 上位細胞 / 栄養 / 繁殖 / 上衣細胞 / 遺伝改変動物 / エネルギーセンシング / 細胞内カルシウム測定 / エネルギー / 低栄養 / グルコース / AMPキナーゼ / 生殖 / 摂食 / ケトン体 |
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| Outline of Final Research Achievements |
In lactating cows, gonadal functions are suppressed because of the malnutrition caused by a big milk yield. The suppression is probably due to a decrease in energy levels. Hindbrain ependymocyte is a candidate for energy sensor involved in the suppression of gonadal activities through suppressing gonadotropin secretion in rats. We aimed to get evidence for ependymocytes to sense glucose levels through AMP kinase which is considered to be a energy-sensing molecule in various kinds of cells. In addition, a neural pathway relaying information on the energy level from ependymocytes to the hypothalamic neurons controlling reproduction. As a result, ependymocytes senses extracellular glucose levels through an AMP kinase-mediated mechanism. In addition, the information on energy level might be transmitted from ependymocytes to neurons located in the hypothalamic paraventricular nucleus. The present result would contribute to treatments of reproductive disorders in lactating cows.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents.2015
Author(s)
Minabe, S., Deura, C., Ikegami, K., Goto, T., Sanbo, M., Hirabayashi, M., Inoue, N., Uenoyama, Y., Maeda, K., Tsukamura, H.
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Journal Title
Endocrinology
Volume: in press
Issue: 6
Pages: 2278-2287
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminisation of luteinising hormone surge and lordosis capacity in therat.2013
Author(s)
Sakakibara, M., Deura, C., Minabe, S., Iwata, K, Uenoyama, Y, Maeda, K.-I., Tsukanura, H.
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Journal Title
Journal of Neuroendocrinology
Volume: 25
Pages: 251-259
Related Report
Peer Reviewed
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[Book] Kisspeptin Signaling in Reproductive Biology2013
Author(s)
Okamura, H., Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y. and Maeda, K.-I.
Total Pages
514
Publisher
Springer
Related Report
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[Book] Kisspeptin Signaling in Reproductive Biology2013
Author(s)
Okaraura, H. , Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y. and Maeda, K. I.
Total Pages
454
Publisher
Springer
Related Report
