Immune responses at the feto-maternal interface : Analysis using artificial tissues including placenta-specific factors
| Project/Area Number |
24380159
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Kiso Yasuo 山口大学, 共同獣医学部, 教授 (10142374)
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| Co-Investigator(Kenkyū-buntansha) |
Kusakabe Takeshi 山口大学, 共同獣医学部, 准教授 (20319536)
加納 聖 山口大学, 共同獣医学部, 准教授 (40312516)
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| Co-Investigator(Renkei-kenkyūsha) |
Kano Kiyoshi 山口大学, 共同獣医学部, 准教授 (40312516)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 胎盤 / 栄養膜 / 胎盤成長因子 / 血管内皮成長因子 / 血管新生 / アポトーシス / オートファジー / 脱落膜 / 流産モデル / ANP / コリン / グレリン / 旨味レセプター / Kiss1 / p53 / MAPLC3 / MHC発現 / TGF-beta / 自然流産モデル |
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| Outline of Final Research Achievements |
To understand immune responses at the feto-maternal interface during pregnancy, we analyzed relationships among immunocompetent cells, placenta-specific factors and cytokine networks using various mouse models. Tumor suppressor factors, autophagy-related factors, abortion-induced factors, diabetes-induced factors, blood pressure regulation factors and obesity-related factors tested in this study can affect kinetics of the placental growth factor and vascular endothelial growth factor, and as a result, their changes can induce abortion or intrauterine growth restriction.
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Intracytoplasmic sperm injection into oocytes matured in vitro and early embryonic development in the owl monkey (Aotus lemurinus).2016
Author(s)
Watanabe H, Matsumoto T, Nishi M, Kusakabe K, Kuraishi T, Hattori S, Matsumoto H, Fukui E, Kuwahara A, Ochi M, Kiso Y, Kai C, Yoshizawa M.
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Journal Title
Reprod Med Biol
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morphological characterization and in vitro maturation of follicular oocytes from the owl monkey (Aotus lemurinus).2015
Author(s)
Matsumoto T, Isobe K, Kusakabe K, Kuraishi T, Hattori S, Nakasato z, Matsumoto H, Fukui E, Kuwata A, Ochi M, Kiso Y, Kai C, Yoshizawa M.
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Journal Title
J Mamm Ova Res
Volume: 32
Pages: 103-108
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morphological characterization of spermatozoa of the night monkey：Morphological characterization of spermatozoa of the night monkey.2015
Author(s)
Nakasato C, Yoshizawa M, Isobe K, Kusakabe K, Kuraishi T, Hattori S, Matsumoto H, Fukui E, Kuwahata A, Ochi M, Kiso Y, Kai C.
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Journal Title
J. Mamm Ova Res
Volume: 32
Pages: 37-40
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morphological characterization of spermatozoa of the night monkey：Morphological characterization of spermatozoa of the night monkey.2015
Author(s)
Nakasato C, Yoshizawa M, Isobe K, Kusakabe K, Kuraishi T, Hattori S, Matsumoto H, Fukui E, Kuwahata A, Ochi M, Kiso Y, Kai C.
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Journal Title
J. Mamm Ova Res.
Volume: 32
Related Report
Peer Reviewed / Open Access
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[Presentation] Oocytes of night monkeys2012
Author(s)
Keisuke Isobe, Yasuo Kiso, 他10名
Organizer
4th Congress of the Asia Pacific Initiative on Reproduction
Place of Presentation
Osaka International Convention Center (Osaka)
Related Report
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