| Project/Area Number |
24380159
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Kiso Yasuo 山口大学, 共同獣医学部, 教授 (10142374)
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| Co-Investigator(Kenkyū-buntansha) |
Kusakabe Takeshi 山口大学, 共同獣医学部, 准教授 (20319536)
加納 聖 山口大学, 共同獣医学部, 准教授 (40312516)
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| Co-Investigator(Renkei-kenkyūsha) |
Kano Kiyoshi 山口大学, 共同獣医学部, 准教授 (40312516)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 胎盤 / 栄養膜 / 胎盤成長因子 / 血管内皮成長因子 / 血管新生 / アポトーシス / オートファジー / 脱落膜 / 流産モデル / ANP / コリン / グレリン / 旨味レセプター / Kiss1 / p53 / MAPLC3 / MHC発現 / TGF-beta / 自然流産モデル |
|---|
| Outline of Final Research Achievements |
To understand immune responses at the feto-maternal interface during pregnancy, we analyzed relationships among immunocompetent cells, placenta-specific factors and cytokine networks using various mouse models. Tumor suppressor factors, autophagy-related factors, abortion-induced factors, diabetes-induced factors, blood pressure regulation factors and obesity-related factors tested in this study can affect kinetics of the placental growth factor and vascular endothelial growth factor, and as a result, their changes can induce abortion or intrauterine growth restriction.
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