| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Aquaporin-11 (AQP11) is an ER-residential water channel protein. AQP11 is the latest member of the mammalian water channel protein family to be described and, thus, its molecular function in the ER is largely unknown. In this study, in order to clarify the molecular function, imaging analysis and proteomics were performed. Imaging analyses showed that AQP11 might have an important role in the regulation of calcium content in the ER. A proteome analysis identified a translocon protein as one of the AQP11-binding partners, and subsequent imaging studies suggested that this interaction was involved in the regulation of calcium content in the ER. Future studies will clarify the biological significance of calcium homeostasis in the ER by AQP11.
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