Analysis of factors of CDV to expand the host range and its control
| Project/Area Number |
24380166
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MAEDA Ken 山口大学, 獣医学部, 教授 (90284273)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOJIMA Masayuki 国立感染症研究所, ウイルス第一部, 室長 (10422411)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | イヌジステンパーウイルス / 野生動物 / ワクチン / 疫学調査 / レセプター / イヌ / モノクローナル抗体 / サル / フェレット / 犬ジステンパーウイルス / SLAM / Nectin4 / 単クローナル抗体 / 遺伝子型 / 飼育動物 / ELISA |
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| Outline of Final Research Achievements |
In this project, epidemiological studies on canine distemper virus (CDV), studies on its pathogenicity and studies on effect of vaccine on large animals were carried out. 1) CDV infection among domestic dogs in Vietnam, wild animals in Kochi and Wakayama and domestic dogs in Japan were analyzed. 2) Efficacy and safety of vaccine for dogs on tigers and lions were evaluated. 3) It was proved that feline SLAM and humane C-type lectins, DC-SIGN and DC-SIGNR, functioned as receptors for CDV. 4) ELISA to detect antibody to CDV in all mammalian species was developed. 5) Method for evaluation of pathogenicity of CDV was established.
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Report
(4 results)
Research Products
(19 results)
