A newly-found 'regulatory antibody': its immunosuppressive mechanisms and prevention of proinflammatory disorders
| Project/Area Number |
24380187
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAWAMOTO Seiji 広島大学, 先端物質科学研究科, 教授 (90294537)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 免疫抑制抗体 / 免疫難病制御 |
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| Outline of Final Research Achievements |
Objective of this study is: 1) to elucidate molecular mechanisms underlying immunosuppressive activity of the newly-found 'regulatory antibody', which shows antigen specificity against nuclear histone H1; and 2) to apply this regulatory antibody to treat proinflammatory disorders.
First, we identified T cell surface cross-reactive antigens, which enabled anti-histone H1 antibody to fulfill its T cell regulatory activity. We also found that the anti-histone H1 antibody not only suppressed type I allergy by acting on mast cells, but also prevented the development of sepsis-like lung injury in mice. These results suggest the effectiveness of anti-histone H1 regulatory antibody against various proinflammatory disorders.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] A novel anti-histone H1 monoclonal antibody, SSV monoclonal antibody, improves lung injury and survival in a mouse model of lipopolysaccharide-induced sepsis-like syndrome2015
Author(s)
Toru Kusano, Kuei-Chen Chiang, Masafumi Inomata, Yayoi Shimada, Naoya Ohmori, Takeshi Goto, Shuji Sato, Shigeru Goto, Toshiaki Nakano, Seiji Kawamoto, Yuki Takaoka, Norio Shiraishi, Takayuki Noguchi, and Seigo Kitano
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Journal Title
Biomed Research International
Volume: 2015
Pages: 491649-491649
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] A unique T cell regulatory role of anti-histone H1 autoantibody: its mode of action through regulatory T cell-dependent and -independent mechanisms2013
Author(s)
Takaoka Y., Kawamoto S., Katayama A., Nakano T., Yamanaka Y., Takahashi M., Shimada Y., Chiang K. C., Ohmori N., Aki T., Goto T., Sato S., Goto S., Chen C. L., Ono K.
Organizer
Federation of Clinical Immunology Societies 2013
Place of Presentation
Boston, MA, USA
Related Report
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