| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
The aim of this research is developing catalytic sp3 C-H functionalization reactions that can be extended to asymmetric variants. We developed the first example of catalytic aerobic oxidative and asymmetric coupling reactions between amines and carbon nucleophiles. The combined catalysis of chiral copper complex and N-oxyl radical was useful for this conversion. Based on the results, we developed sp3 C-H alkoxylation, amidation, acetoxylation, and oxygenation reactions.
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