Development of New Chemoselective Catalyst and its Application to Green Synthetic Process
| Project/Area Number |
24390004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
OHSHIMA Takashi 九州大学, 薬学研究科(研究院), 教授 (10313123)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 触媒 / 化学選択性 / 環境調和 / 有機合成 / 有機化学 |
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| Outline of Final Research Achievements |
In order to realize protecting group-free environmentally friendly synthetic processes, we developed the following catalytic systems, which can reverse innate reactivity of functional groups in a catalytic manner.
(1) chemoselective acylation reactions of alcohol over amine catalyzed by zinc, cobalt, or iron catalyst, (2) chemoselective conjugate addition of alcohol over amine catalyzed by cupper catalyst, and (3) chemoselective and enantioselective alkynylation of ketimine over aldehyde and aldimine.
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Report
(4 results)
Research Products
(150 results)
