| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
The goal of the present study was the development of effective cancer therapy by gene transfer of interferon -γ(IFN-γ). For this goal, it was hypothesized that IDO-1, an IFN-γ-induced immunosuppressive molecule, and tumor-associated macrophage (TAM) might hinder anti-tumor effect of IFN-γ. Base on this hypothesis, the role of these factors in the IFN-γ cancer gene therapy was investigated. We found that TAM reduced the anti-tumor effect of IFN-γ and depletion of TAM restored it. On the other hand, IDO-1 hardly affected the anti-tumor effect of IFN-γ. In the process of these investigations, we also found that persistent transgene expression of antigenic protein induced the transgene-specific immune response, which removed the transgene-expressing cells.
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