| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In this study, we succeeded in the generation of novel monoclonal antibodies reactive with a fucosylated glycan epitope sialyl Lewis X based on a newly developed method. In mouse contact hypersensitivity model, both F1 and F2 significantly inhibited ear swelling by blocking sialyl Lewis X-dependent leukocyte infiltration upon antigen challenge in sensitized animals. In silicosis model, these monoclonal antibodies inhibited lung fibrosis at the chronic stage by blocking sialyl Lewis X-dependent acute leukocyte infiltration after administration of silica. Taken together, these results indicate that functional blockage of sialyl Lewis X at particular stage of inflammation leads to efficient control over inflammatory disorders.
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