| Research Collaborator |
Kitano Katsunori , 共同研究者
Tsubo Yasuhiro , 共同研究者
Tachibana Masao , 共同研究者
Matsumoto Aikihiro , 共同研究者
Moritoh Satoru , 共同研究者
Seya Yasuhiro , 共同研究者
Feng Yue , 共同研究者
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Retinal bipolar cells relay important visual information that enables, for example, contrast and edge detection. We focused on TRPM1 and mGluR6 that regulate retinal ON bipolar function by using mutant mice. We observed oscillatory spontaneous activity only in TRPM1 mutant mouse retina. The oscillations result from morphological changes in the ON bipolar cell synaptic terminal, consistent with a mathematical model. We also developed operant systems for studying visual acuity in mice. Altogether, we have established a general toolbox that can be used to study visual function from molecules to consciousness in an area of relevance to retinal regeneration.
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