Functional deorphaning of novel phospholipases

• Project/Area Number: 24390021
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: MURAKAMI Makoto 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 参事研究員 (60276607)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 酵素 / 脂質 / 生体分子 / 遺伝子 / 組織・細胞 / 遺伝子改変マウス / リピドミクス / 病態 / 細胞・組織 / 分子生物学 / ホスホリパーゼ / ノックアウトマウス / リン脂質 / 脂肪酸

Outline of Final Research Achievements

Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to generate fatty acids and lysophospholipids. Mammalian genomes encode genes for more than 30 PLA2s or related enzymes, which are subdivided into several groups on the basis of their structures and enzymatic properties. In this study, we analyzed knockout mice for several PLA2s whose functions had been unknown to reveal their pathophysiological roles. We provide evidence that (1) sPLA2-IIE regulates metabolism by hydrolyzing lipoprotein phospholipids, (2) sPLA2-XIIA regulates mast cell activation and acquired immunity, (3) PNPLA7 controls hepatic choline homeostasis and thereby systemic metabolism, and (4) PNPLA1 regulates epidermal ceramide metabolism and associated skin barrier function.

Research Products

• [Journal Article] Secreted phospholipase A2s and mast cells. (2015)
  • Author(s): Murakami, M., and Taketomi, Y.
  • Journal Title: Allergology Int. Volume: 64 Issue: 10 Pages: 4-10
  • DOI: 10.1371/journal.pone.0109409
  • NAID: 130004873126
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Secreted phospholipase A₂ and mast cells (2015)
  • Author(s): Murakami M, Taketomi Y.
  • Journal Title: Allergology International Volume: 64 Issue: 1 Pages: 4-10
  • DOI: 10.1016/j.alit.2014.07.005
  • NAID: 130004873126
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells. (2015)
  • Author(s): Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J.R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
  • Journal Title: Circ. Res. Volume: 116 Issue: 7 Pages: 1170-1181
  • DOI: 10.1161/circresaha.116.305363
  • Peer Reviewed / Open Access
• [Journal Article] A new era of secreted phospholipase A2. (2015)
  • Author(s): Murakami, M., Sato, H., Miki, Y., Yamamoto, K., and Taketomi, Y.
  • Journal Title: J. Lipid Res. Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. (2014)
  • Author(s): Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
  • Journal Title: Cell Metab. Volume: 20 Issue: 1 Pages: 119-132
  • DOI: 10.1016/j.cmet.2014.05.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition. (2014)
  • Author(s): Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K, Lambeau G.
  • Journal Title: Biochimie Volume: 107Pt A Pages: 105-113
  • DOI: 10.1016/j.biochi.2014.09.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction. (2014)
  • Author(s): Mishina H, Watanabe K, Tamaru S, Watanabe Y, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Inoue O, Murakami M, Hanasaki K, Kugiyama K.
  • Journal Title: Circ Res. Volume: 114 Issue: 3 Pages: 493-504
  • DOI: 10.1161/circresaha.114.302319
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. (2014)
  • Author(s): Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
  • Journal Title: J. Immunol. Volume: 192 Issue: 3 Pages: 1130-1137
  • DOI: 10.4049/jimmunol.1300290
  • Peer Reviewed
• [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. (2013)
  • Author(s): Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
  • Journal Title: J Exp Med. Volume: 210 Issue: 6 Pages: 1217-1234
  • DOI: 10.1084/jem.20121887
  • Peer Reviewed
• [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. (2013)
  • Author(s): Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
  • Journal Title: Nature Immunol. Volume: (印刷中) Issue: 6 Pages: 554-63
  • DOI: 10.1038/ni.2586
  • Peer Reviewed
• [Journal Article] Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation. (2013)
  • Author(s): Tamaru S, Mishina H, Watanabe Y, Watanabe K, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Murakami M, Hanasaki K, Kugiyama K.
  • Journal Title: J Immunol. Volume: 191 Issue: 3 Pages: 1021-1028
  • DOI: 10.4049/jimmunol.1300738
  • Peer Reviewed
• [Journal Article] AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice. (2013)
  • Author(s): Hwang SL, Li X, Lu Y, Jin Y, Jeong YT, Kim YD, Lee IK, Taketomi Y, Sato H, Cho YS, Murakami M, Chang HW.
  • Journal Title: J Allergy Clin Immunol. Volume: 132 Issue: 3 Pages: 729-736
  • DOI: 10.1016/j.jaci.2013.02.018
  • Peer Reviewed
• [Journal Article] 疾病における脂質代謝ネットワークの機能. (2013)
  • Author(s): 三木寿美、山本圭、村上誠
  • Journal Title: オレオサイエンス Volume: 13 Pages: 23-29
  • NAID: 130005122088
• [Journal Article] 脂質メディエーターによるアレルギー制御 (2013)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: 実験医学増刊―病態の理解に向かうアレルギー疾患研究 Volume: 31 Pages: 118-127
• [Journal Article] 脂質ネットワークとアナフィラキシー (2013)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: アレルギー・免疫 Volume: 20 Pages: 38-48
• [Journal Article] 分泌性ホスホリパーゼA2による免疫制御 (2013)
  • Author(s): 村上誠
  • Journal Title: 細胞工学 Volume: 32 Pages: 1265-1271
• [Journal Article] Emerging roles of secreted phospholipase A2 enzymes: an update. (2013)
  • Author(s): Murakami M, Lambeau G.
  • Journal Title: Biochimie Volume: 95 Issue: 1 Pages: 43-50
  • DOI: 10.1016/j.biochi.2012.09.007
  • Peer Reviewed
• [Journal Article] The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza (2013)
  • Author(s): Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, Imai Y.
  • Journal Title: Cell Volume: 153 Issue: 1 Pages: 112-125
  • DOI: 10.1016/j.cell.2013.02.027
  • Peer Reviewed
• [Journal Article] Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice. (2013)
  • Author(s): Ait-Oufella H, Herbin O, Lahoute C, Coatrieux C, Loyer X, Joffre J, Laurans L, Ramkhelawon B, Blanc-Brude O, Karabina S, Girard CA, Payré C, Yamamoto K, Binder CJ, Murakami M, Tedgui A, Lambeau G, Mallat Z.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Issue: 3 Pages: 466-473
  • DOI: 10.1161/atvbaha.112.300309
  • Peer Reviewed
• [Journal Article] Small RNA Transcriptomes of Two Types of Exosomes in Human Whole Saliva Determined by Next Generation Sequencing (2013)
  • Author(s): Ogawa, Y.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Issue: 1 Pages: 66-75
  • DOI: 10.1248/bpb.b12-00607
  • NAID: 130003361349
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] The expression of phospholipase A_2 group X is inversely associated with metastasis in colorecta cancer (2013)
  • Author(s): Hiyoshi, M., 他9名
  • Journal Title: Oncol. Lett. Volume: 5 Pages: 533-538
  • Peer Reviewed
• [Journal Article] Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis (2012)
  • Author(s): Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S
  • Journal Title: Oncogene Volume: 31(24) Issue: 24 Pages: 2943-2952
  • DOI: 10.1038/onc.2011.472
  • Peer Reviewed
• [Journal Article] Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells (2012)
  • Author(s): Lu, Y., 他5名
  • Journal Title: Food Chem. Toxicol. Volume: 50 Issue: 12 Pages: 4382-4388
  • DOI: 10.1016/j.fct.2012.08.053
  • Peer Reviewed
• [Journal Article] PGD_2 induces eotaxin-3 via PPARγ from sebocytes : a possible pathogenesis of eosinophilic pustular folliculitis (2012)
  • Author(s): Nakahigashi, K., et al
  • Journal Title: J.Allergy Clin.Immunol. Volume: 129 Issue: 2 Pages: 536-543
  • DOI: 10.1016/j.jaci.2011.11.034
  • Peer Reviewed
• [Journal Article] アナフィラキシーを制御する脂質ネットワーク (2012)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: 臨床免疫・アレルギー科 Volume: 58 Pages: 550-559
• [Presentation] IID型分泌性ホスホリパーゼA2 は乾癬を抑制する (2015)
  • Author(s): 三木寿美、山本圭、村上誠
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（兵庫県神戸市）
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] メタボリックシンドロームにおけるsPLA2受容体の機能 (2015)
  • Author(s): 池田さや、佐藤弘泰、武富芳隆、田中弘文、村上誠
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（兵庫県神戸市）
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] New insights into PLA2s from outside and inside. (2015)
  • Author(s): Murakami, M.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
  • Invited
• [Presentation] Group X sPLA2 protects from colitis by mobilizing ω3 polyunsaturated fatty acid metabolites. (2015)
  • Author(s): Remi Murase, Yoshitaka Taketomi, Hiroyasu Sato, Kei Yamamoto, Toshinori Yamamoto, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Adipocyte-inducible group V and IIE sPLA2s play distinct roles in metabolic disorders. (2015)
  • Author(s): Hiroyasu Sato, Yoshitaka Taketomi, Kei Yamamoto, Shuntaro Hara, Keishi Miyata, Yuichi Oike, Michael H. Gelb, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Deficiency of group III sPLA2 protects from metabolic disorders. (2015)
  • Author(s): Hiroyasu Sato, Yoshitaka Taketomi, Kei Yamamoto, Shuntaro Hara, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Deficiency of group III sPLA2 protects from atherosclerosis. (2015)
  • Author(s): Yoshitaka Taketomi, Takuro Miyazaki, Hiroyasu Sato, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Group III sPLA2 facilitates mast cell maturation and anaphylaxis. (2015)
  • Author(s): Yoshitaka Taketomi, Noriko Ueno, Hiroyasu Sato, Kei Yamamoto, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Skin abnormalities in group III sPLA2-deficient mice. (2015)
  • Author(s): Yuki Endo, Yoshitaka Taketomi, Kei Yamamoto, Tetsuyuki Kobayashi, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Group IID sPLA2 resolves psoriasis by driving pro-resolving lipid mediators. (2015)
  • Author(s): Yoshimi Miki, Kei Yamamoto, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Group IIF sPLA2 promotes skin carcinogenesis. (2015)
  • Author(s): Kei Yamamoto, Yoshimi Miki, Mariko Sato, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] A unique lipid pathway driven by group IIF sPLA2 undelies epidermal-hyperplasic disorders. (2015)
  • Author(s): Kei Yamamoto, Yoshimi Miki, Yoshitaka Taketomi, Naotomo Kambe, Kenji Kabashima, Gérard Lambeau, Michael H. Gelb, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Impaired skin barrier function in PNPLA1-deficient mice. (2015)
  • Author(s): Tatsuki Anjo, Tetsuya Hirabayashi, Kohei Yokoyama, Kei Yamamoto, Ayano Naoe, Hisashi Tsujimura, Junko Ishikawa, Agustí Muñoz-Garcia, Alan R. Brash, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Phosphatidylethanolamine dynamics in osteoclast fusion. (2015)
  • Author(s): Atsushi Irie, Kei Yamamoto, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] The role of type II PAF-AH in IgE-mediated mast cell activation. (2015)
  • Author(s): Nozomu Kono, Yuta Shimanaka, Yoshitaka Taketomi, Makoto Murakami, and Hiroyuki Arai.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Analysis of two major intracellular PLA2 in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts. (2015)
  • Author(s): Noriko Ueno, Yoshitaka Taketomi, Kei Yamamoto, Tetsuya Hirabayashi, Hiroki Nakanishi, and Makoto Murakami.
  • Organizer: The 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] 炎症性腸疾患における分泌性ホスホリパーゼA2の役割 (2014)
  • Author(s): 村瀬礼美、武富芳隆、佐藤弘泰. 山本圭、山元俊憲、村上誠.
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] V型分泌性ホスホリパーゼA2は「Th2/M2-prone sPLA2」である (2014)
  • Author(s): 佐藤弘泰、武富芳隆、池田さや、村上誠.
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] アルケニル型リゾホスファチジルエタノールアミンはIIF型sPLA2依存的な表皮肥厚性疾患のバイオマーカーである (2014)
  • Author(s): 山本圭、三木寿美、村上誠.
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 皮膚バリア形成に関わる新規脂質代謝酵素PNPLA1 (2014)
  • Author(s): 安城樹、平林哲也、村上誠.
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ホスホリパーゼA2を起点とした脂質免疫制御と疾患 (2014)
  • Author(s): 武富芳隆、村上誠.
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] プロスタグランジンE2合成系酵素の発現抑制効果を有する自然薯の抗炎症・抗腫瘍効果 (2014)
  • Author(s): 津嘉山泉、武田泰典、目賀拓斗、戸田圭祐、中谷嘉那子、田中充樹、荒川俊哉、山本圭、村上誠、川上祐生、高橋吉孝、山本登志子.
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Ⅲ型分泌性ホスホリパーゼA2の欠損はメタボリックシンドロームを改善する (2014)
  • Author(s): 佐藤弘泰、武富芳隆、山本圭、原俊太郎、村上誠.
  • Organizer: 第35回日本炎症再生医学会
  • Place of Presentation: 万国津梁館（沖縄県名護市）
  • Year and Date: 2014-07-01 – 2014-07-04
• [Presentation] 皮膚バリア機能における新規脂質代謝酵素PNPLA1の役割 (2014)
  • Author(s): 安城樹、平林哲也、山本圭、村上誠.
  • Organizer: 第56回日本脂質生化学会
  • Place of Presentation: 近畿大学（大阪府東大阪市）
  • Year and Date: 2014-06-06 – 2014-06-07
• [Presentation] 炎症性腸疾患における分泌性ホスホリパーゼA2の機能解析 (2014)
  • Author(s): 村瀬礼美、武富芳隆、山本圭、山元俊憲、村上誠.
  • Organizer: 第56回日本脂質生化学会
  • Place of Presentation: 近畿大学（大阪府東大阪市）
  • Year and Date: 2014-06-06 – 2014-06-07
• [Presentation] III型分泌性ホスホリパーゼA2は動脈硬化を制御する. (2014)
  • Author(s): 武富芳隆、宮崎拓郎、佐藤弘泰、村上誠.
  • Organizer: 第86回日本薬学会
  • Place of Presentation: 熊本
• [Presentation] III型分泌性ホスホリパーゼA2はメタボリックシンドロームを制御する. (2014)
  • Author(s): 佐藤弘泰、武富芳隆、牛田絢子、山本圭、小島卓巳、原俊太郎、村上誠.
  • Organizer: 第86回日本薬学会
  • Place of Presentation: 熊本
• [Presentation] 炎症性腸疾患における分泌性ホスホリパーゼA2の機能解析. (2014)
  • Author(s): 村瀬礼美、武富芳隆、山本圭、山元俊憲、村上誠.
  • Organizer: 第86回日本薬学会
  • Place of Presentation: 熊本
• [Presentation] 全身性代謝応答を制御するリゾホスホリパーゼ (2013)
  • Author(s): 村上誠
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2013-03-30
• [Presentation] Deciphering the physiological functions of sPLA2s. (2013)
  • Author(s): Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K.
  • Organizer: The 5th International Conference of Phospholipase A2 Mediated Signaling in Translational Medicine.
  • Place of Presentation: New Orleans, USA
  • Invited
• [Presentation] IIF型分泌性ホスホリパーゼA2は表皮の恒常性維持および病態に寄与する. (2013)
  • Author(s): 山本圭、三木寿美、佐藤真利子、武富芳隆、池田和貴、中西広樹、田口良、村上誠.
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 仙台
• [Presentation] 脂肪過栄養により誘導されるsPLA2-VとsPLA2-IIEは全身性脂質代謝を制御する. (2013)
  • Author(s): 佐藤弘泰、武富芳隆、牛田絢子、小島卓巳、山本圭、原俊太郎、宮田敬士、尾池雄一、村上誠.
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 仙台
• [Presentation] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. (2013)
  • Author(s): Miki, Y., Yamamoto, K., and Murakami, M.
  • Organizer: FASEB Summer Research Conference on Lysophospholipids and Other Related Mediators
  • Place of Presentation: ニセコ
• [Presentation] sPLA2の新しいパラダイム. (2013)
  • Author(s): 村上誠、武富芳隆、佐藤弘泰、三木寿美、山本圭.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 炎症性腸疾患における分泌性ホスホリパーゼA2の機能解析. (2013)
  • Author(s): 村瀬礼美、武富芳隆、三木寿美、佐藤弘泰、山本圭、山元俊憲、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] 皮膚癌形成における分泌性ホスホリパーゼA2の機能解析. (2013)
  • Author(s): 佐藤真利子、山本圭、三木寿美、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] III型分泌性ホスホリパーゼA2の欠損はメタボリックシンドロームを改善する. (2013)
  • Author(s): 佐藤弘泰、武富芳隆、牛田絢子、山本圭、小島卓巳、原俊太郎、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] III型分泌性ホスホリパーゼA2は動脈硬化を制御する. (2013)
  • Author(s): 武富芳隆、宮崎拓郎、佐藤弘泰、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] III型分泌性ホスホリパーゼA2は接触性皮膚炎（遅延型アレルギー）を抑制する. (2013)
  • Author(s): 遠藤由妃、武富芳隆、小林哲幸、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] IIF型分泌性ホスホリパーゼA2は皮膚疾患の進行に寄与する. (2013)
  • Author(s): 山本圭、三木寿美、佐藤真利子、椛島健次、石川由紀夫、石井壽晴、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] IID型分泌性ホスホリパーゼA2は抗炎症性脂質メディエーターを動員して皮膚炎を寛解する. (2013)
  • Author(s): 三木寿美, 山本圭, 村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] 破骨細胞融合におけるホスファチジルエタノールアミン動態の解析. (2013)
  • Author(s): 入江敦、武富芳隆、山本圭、村上誠.
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] Two secreted phospholipase A2 enzymes, PLA2G5 and PLA2G2E, are induced in hypertrophic adipocytes and distinctly regulate obesity. (2013)
  • Author(s): Sato, H., Taketomi, Y., Ushida, A., Yamamoto, K., Gelb, M.H., and Murakami, M.
  • Organizer: The 13th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: San Juan, Puerto Rico
• [Presentation] Epidermal phospholipase A2 group IIF regulates keratinocyte differentiation and skin barrier through driving a unique set of lipid products. (2013)
  • Author(s): Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G., and Murakami, M.
  • Organizer: The 13th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: San Juan, Puerto Rico
• [Presentation] Group IID phospholipase A2 resolves contact hypersensitivity and psoriasis by driving antiinflammatory lipid mediators. (2013)
  • Author(s): Miki, Y., Yamamoto, K., Taketomi, Y., Gelb, M.H., Lambeau, G., and Murakami, M.
  • Organizer: The 13th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.
  • Place of Presentation: San Juan, Puerto Rico
• [Presentation] Epidermal phospholipase A2 group IIF regulates keratinocyte differentiation and skin barrier through driving a unique set of lipid products. (2013)
  • Author(s): Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Gelb, M.H., Lambeau, G., and Murakami, M.
  • Organizer: The 16th GEM-10th GERLI meeting: from membranes to pathologies
  • Place of Presentation: Saint-Jean Cap Ferrat, France
• [Presentation] 新規リゾホスホリパーゼによるGPC産生経路の生理的意義 (2012)
  • Author(s): 平林哲也、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2012-12-15
• [Presentation] 遺伝子欠損マウスを用いた新規細胞内リゾホスホリパーゼの機能解析 (2012)
  • Author(s): 毛利美紗、平林哲也、島村透、安城樹、小林哲幸、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] 皮膚病態生理機能におけるIIE型分泌性ホスホリパーゼA_2の役割 (2012)
  • Author(s): 山本圭、佐藤弘泰、佐藤真利子、三木寿美、武富芳隆、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] タボリックシンドロームにおけるIID型、IIE型分泌性ホスホリパーゼA_2の役割 (2012)
  • Author(s): 牛田絢子、佐藤弘泰、武富芳隆、山本圭、小島卓巳、三木寿美、小林哲幸、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] マスト細胞を制御するホスホリパーゼA_2分子群の網羅的解析 (2012)
  • Author(s): 武富芳隆、上野紀子、小島卓巳、田中智之、依田恵美子、佐藤弘泰、平林哲也、山本圭、原俊太郎、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] sPLA_2-IIDの欠損は接触性皮膚炎の感作相後期においてリンパ節の炎症を増悪する (2012)
  • Author(s): 三木寿美、山本圭、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] メタボリックシンドロームにおけるX型分泌性ホスホリパーゼA_2の機能 (2012)
  • Author(s): 佐藤弘泰、武富芳隆、山本圭、小島卓巳、原俊太郎、村上誠
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] 酸化リン脂質選択的ホスホリパーゼPAF-AH2のマスト細胞活性化シグナルにおける機能 (2012)
  • Author(s): 河野望、嶋中雄太、武富芳隆、村上誠、新井洋由
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] 抗原非依存性炎症におけるプロスタグランジンの役割 (2012)
  • Author(s): 森本和志、白田成俊、武富芳隆、土屋創建、瀬木-西田恵里、田中智之、椛島健次、村上誠、成宮周、杉本幸彦
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] sPLA_2群のバイオロジー (2012)
  • Author(s): 村上誠
  • Organizer: フォーラム・イン・ドージン
  • Place of Presentation: 熊本(招待講演)
  • Year and Date: 2012-11-16
• [Presentation] 細胞外リン脂質環境を制御するsPLA_2群のバイオロジー (2012)
  • Author(s): 村上誠
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2012-11-15
• [Presentation] PLA2G2D, a Lymphoid tissue-associated secreted phospholipase A_2, resolves inflammation by driving an anti-inflammatory lipid program (2012)
  • Author(s): Miki, Y., 他3名
  • Organizer: The Annual IEIIS Meeting 2012
  • Place of Presentation: Tokyo
  • Year and Date: 2012-10-24
• [Presentation] PLA2G3, a mammalian homolog of anaphylactic secreted phospholipase A_2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD_2 loop (2012)
  • Author(s): Taketomi, Y., 他8名
  • Organizer: The Annual IEIIS Meeting 2012
  • Place of Presentation: Tokyo
  • Year and Date: 2012-10-24
• [Presentation] PLA2G5, a secreted phospholipase A_2 induced in hypertrophic adipocytes, regulates lipid metabolism and obesity (2012)
  • Author(s): Sato, H., 他9名
  • Organizer: The Annual IEIIS Meeting 2012
  • Place of Presentation: Tokyo
  • Year and Date: 2012-10-24
• [Presentation] Novel roles of phospholipase A_2 enzymes and lipid machineries in allergic inflammation (2012)
  • Author(s): Murakami, M.
  • Organizer: International Symposium "Allergy and Inflammation"
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2012-10-13
• [Presentation] PLA2G3, a mammalian homolog of anaphylactic phospholipase A_2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD_2 loop (2012)
  • Author(s): Taketomi, Y., 他7名
  • Organizer: New Frontiers of Metabolism Research in Biomedical Sciences(CREST symposium)
  • Place of Presentation: Tokyo
  • Year and Date: 2012-09-27
• [Presentation] sPLA_2とメタボリックシンドローム (2012)
  • Author(s): 村上誠
  • Organizer: 日本炎症再生医学会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2012-07-06
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2012)
  • Author(s): 武富芳隆、上野紀子、小島卓巳、田中智之、佐藤弘泰、西藤泰昌、山本圭、有竹浩介、裏出良博、杉本幸彦、成宮周、原俊太郎、村上誠
  • Organizer: 日本炎症再生医学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-05
• [Presentation] 油はなぜ体に必要か?脂質代謝酵素のノックアウトマウスから脂質シグナリングの重要性を考える (2012)
  • Author(s): 村上誠
  • Organizer: モロシヌス研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-06-15
• [Presentation] マスト細胞のcPLA_<2α>により遊離されるアラキドン酸は局所環境でmPGES-1によりPGE_2へ変換され抗アレルギーに関わる (2012)
  • Author(s): 上野紀子、武富芳隆、山本圭、平林哲也、亀井大輔、北芳博、清水孝雄、新沢康英、辻本賀英、池田和貴、田口良、村上誠
  • Organizer: 日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-08
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2012)
  • Author(s): 武富芳隆、上野紀子、小島卓巳、田中智之、佐藤弘泰、西藤泰昌、山本圭、有竹浩介、裏出良博、杉本幸彦、成宮周、原俊太郎、村上誠
  • Organizer: 日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-08
• [Presentation] sPLA_<2S> in skin biology (2012)
  • Author(s): Murakami, M.
  • Organizer: International Conference of Lipid Mediators
  • Place of Presentation: Fukuoka(招待講演)
  • Year and Date: 2012-06-06
• [Presentation] 脂肪過栄養により誘導されるsPLA2-VとsPLA2-IIEは全身性脂質代謝を制御する.
  • Author(s): 佐藤弘泰、武富芳隆、牛田絢子、山本圭、宮田敬士、尾池雄一、村上誠.
  • Organizer: 第８回炎症・脂質代謝・メタボリサーチフォーラム
  • Place of Presentation: 東京
• [Presentation] PLA2を起点とした脂質ネットワークによるアレルギー制御.
  • Author(s): 武富芳隆、村上誠.
  • Organizer: 第23回東京免疫フォーラム
  • Place of Presentation: 東京
• [Book] 遺伝子医学MOOK: 最新生理活性脂質研究ー実験手法、基礎的知識とその応用 (2013)
  • Author(s): 横溝岳彦、青木淳賢、杉本幸彦、村上誠
  • Total Pages: 304
  • Publisher: メディカルドウ
• [Remarks] 脂肪細胞から分泌されるリン脂質分解酵素PLA2G5とPLA2G2Eは肥満において異なる役割を担う
  • URL: http://first.lifesciencedb.jp/archives/8936#more-8936
• [Remarks] 脂肪細胞から分泌される脂質代謝酵素による肥満の新しい調節機構の発見
  • URL: http://www.igakuken.or.jp/topics/2014/0606.html
• [Remarks] 脂肪細胞から分泌される脂質代謝酵素による肥満の新しい調節機構の発見
  • URL: http://www.jst.go.jp/pr/announce/20140606/
• [Remarks] マスト細胞の成熟経路の発見
  • URL: http://www.igakuken.or.jp/lipid/reseacch8.html
• [Remarks] 体に優しい脂質を働かせ、炎症にブレーキをかける酵素の同定
  • URL: http://www.igakuken.or.jp/lipid/research9.html
• [Remarks]
  • URL: http://www.igakuken.or.jp/research/project/res_prj23.html
• [Patent(Industrial Property Rights)] 皮膚バリア機能促進剤のスクリーニング方法 (2014)
  • Inventor(s): 村上誠、平林哲也
  • Industrial Property Rights Holder: 村上誠、平林哲也
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-116066
  • Filing Date: 2014-06-04
• [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法 (2014)
  • Inventor(s): 村上誠、武富芳隆
  • Industrial Property Rights Holder: 村上誠、武富芳隆
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-073775
  • Filing Date: 2014-03-29
• [Patent(Industrial Property Rights)] PLA2G2Fを指標とした表皮角化細胞の過増殖性疾患に対する薬剤のスクリーニング方法 (2013)
  • Inventor(s): 村上誠、山本圭
  • Industrial Property Rights Holder: 村上誠、山本圭
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-240871
  • Filing Date: 2013-11-21
• [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法 (2013)
  • Inventor(s): 村上誠、武富芳隆
  • Industrial Property Rights Holder: 東京都医学総合研究所
  • Industrial Property Number: 2013-073775
  • Filing Date: 2013-03-29
• [Patent(Industrial Property Rights)] PLA2G2Fを指標とした抗皮膚癌薬のスクリーニング方法 (2012)
  • Inventor(s): 村上誠、山本圭
  • Industrial Property Rights Holder: 東京都医学総合研究所
  • Industrial Property Number: 2012-025531
  • Filing Date: 2012-11-21