| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
The pharmaceutical products extremely rarely cause a fatal liver damage in some patients. It is owing to the individual difference of the immune system. It was difficult to reproduce a liver damage in animals including individual difference. We have succeeded in construction of new model mice possibly overcoming such problem. We will be able to evaluate the risk of DILI aggravation with such mice in the future. In addition, we found a better condition to evaluate a drug toxicity with this mice model and also clarified its background mechanism. Furthermore, we built an in vitro experimental system that enabled us to evaluate aggravation of DILI without using an animal.
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