Development of support system for dosage adjustment to avoid drug-drug interactions caused by fluoropyrimidine anti-cancer drugs
| Project/Area Number |
24390038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAWADA Yasufumi 東京大学, 大学院薬学系研究科, 教授 (80114502)
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| Co-Investigator(Kenkyū-buntansha) |
HORI Satoko 東京大学, 大学院情報学環, 准教授 (70313145)
SATOH Hiroki 東京大学, 大学院薬学系研究科, 助教 (80451855)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 薬物間相互作用 / フッ化ピリミジン系抗癌薬 / 薬物代謝酵素 / フェニトイン / ワルファリン / 薬物相互作用 |
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| Outline of Final Research Achievements |
Fluoropyrimidine anti-cancer drugs cause the drug-drug interactions with anti-epileptic drugs (phenytoin) and anticoagulants (warfarin). In this study, we conducted experiment using HepaRG cells, and then elucidated the mechanism of this interaction. Also, we collected cases which were co-administrated fluoropyrimidine anti-cancer drugs and phenytoin or warfarin, and constructed pharmacokinetic-pharmacodynamic model that can represent the interaction. When used in combination with fluoropyrimidine anti-cancer drugs, it is possible to predict a phenytoin dosage as not to vary the phenytoin concentration using the constructed models.
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Report
(4 results)
Research Products
(2 results)
