Development of the transcutaneous influenza vaccine formulation using an self-dissolving microneedle patch
| Project/Area Number |
24390041
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OKADA NAOKI 大阪大学, 薬学研究科(研究院), 准教授 (90312123)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Keywords | ワクチン / マイクロニードル / インフルエンザ / 臨床研究 |
|---|
| Outline of Final Research Achievements |
In this study, we made efforts for collection of the basic information and improvement of the fundamental technology for the development of the transcutaneous vaccine formulation using our original self-dissolving microneedle patch. Also, we focused on shortening for the transition period to the clinical trial and the manufacture study of the transcutaneous vaccine formulation by conducting clinical research to investigate safety and efficacy. Furthermore, we pushed forward with the screening of a promising candidate as adjuvant for transcutaneous vaccine formulations mainly on Toll-like receptor ligands and attempted to create the future-type transcutaneous influenza vaccine formulation capable of achieving stable efficacy based on the vaccine dose reduction, the vaccination frequency reduction, and the immune response reinforcement.
|
Report
(4 results)
Research Products
(76 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza2012
Author(s)
Kazuhiko Matsuo, Sachiko Hirobe, Yayoi Yokota, Yurika AyabeMasashi Seto, Ying-Shu Quan, Fumio Kamiyama, Takahiro Tougan, Toshihiro Horii, Yohei Mukai, Naoki Okada, and Shinsaku N akagawa
-
Journal Title
Journal of Controlled Release
Volume: 160
Pages: 495-501
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
