| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
This research investigated the therapeutic effect of albumin-thioredoxin (HSA-Trx) on multiple organ failure model using mouse models of primary organ failure such as lungs, liver and kidney.
1) HSA-Trx was found to produce effective therapeutic effect in Bleomycin induced pulmonary fibrosis. 2) The inhibitory effect of fusion protein on acetaminophen induced liver disorder was found to occur in a concentration dependent manner. 3) Effectiveness of the fusion protein in cisplatin nephropathy was evaluated. The fusion protein was found to inhibit increases in SCr, BUN and NAG activity, as well as reduction in CLcr.
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