Design and Evaluation of Next Generation Albumin-thioredoxin Fusion Protein for Multiple Organ Failure Treatment
Project/Area Number |
24390043
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Sojo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657)
WATANABE Hiroshi 熊本大学, 薬学部, 准教授 (70398220)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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Keywords | アルブミン / ナノメディスン / レドックス / 多臓器不全治療 / 病態モデル / 肺障害 / 肝障害 / 腎障害 / チオレドキン |
Outline of Final Research Achievements |
This research investigated the therapeutic effect of albumin-thioredoxin (HSA-Trx) on multiple organ failure model using mouse models of primary organ failure such as lungs, liver and kidney. 1) HSA-Trx was found to produce effective therapeutic effect in Bleomycin induced pulmonary fibrosis. 2) The inhibitory effect of fusion protein on acetaminophen induced liver disorder was found to occur in a concentration dependent manner. 3) Effectiveness of the fusion protein in cisplatin nephropathy was evaluated. The fusion protein was found to inhibit increases in SCr, BUN and NAG activity, as well as reduction in CLcr.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Cross-linked human serum albumin dimer has the potential for use as a plasma retaining-agent for the fatty acid-conjugated antidiabetic drugs.2015
Author(s)
Taguchi K, Chuang VTG, Yamasaki K, Urata Y, Tanaka R, Anraku M, Seo H, Kawai K, Maruyama T, Komatsu T, Otagiri M
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Journal Title
J Pharm Pharmacol.
Volume: 67
Issue: 2
Pages: 255-263
DOI
Related Report
Peer Reviewed
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[Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models.2015
Author(s)
Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T.
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Journal Title
J Pharmacol Exp Ther
Volume: 352
Issue: 2
Pages: 244-257
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tuning of Poly-S-Nitrosated Human Serum Albumin as Superior Antitumor Nanomedicine2014
Author(s)
Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T
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Journal Title
J Pharm Sci
Volume: 103
Issue: 7
Pages: 2184-2188
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of chitosan on oxidative stress and related factors in hemodialysis patients.2014
Author(s)
Anraku M, Tanaka M, Hiraga A, Nagumo K, Imafuku T, Maezaki Y, Iohara D, Uekama K, Watanabe H, Hirayama F, Maruyama T, Otagiri M
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Journal Title
Carbohydr Polym
Volume: 112
Pages: 152-157
DOI
Related Report
Peer Reviewed
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[Journal Article] Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.2014
Author(s)
Kodama A, Watanabe H, Tanaka R, Kondo M, Chuang VT, Wu Q, Endo M, Ishima Y, Fukagawa M, Otagiri M, Maruyama T.
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Journal Title
Biochim Biophys Acta.
Volume: 1840
Issue: 3
Pages: 1152-1162
DOI
Related Report
Peer Reviewed
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[Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
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Journal Title
FASEB J
Volume: 27
Issue: 1
Pages: 391-398
DOI
Related Report
Peer Reviewed
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[Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
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Journal Title
J. Pharm. Sci
Volume: 101
Issue: 9
Pages: 3222-3229
DOI
Related Report
Peer Reviewed
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[Journal Article] Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy ill the rat model.2012
Author(s)
Kaga M, Li H, Ohta H, Taguchi K, Ogaki S, Izumi H, Inagaki M, Tsuchiya S, Okamura K, 0tagiri M, Sakai H, and Yaegashi N
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Journal Title
Life Sci.
Volume: 91
Pages: 420-428
Related Report
Peer Reviewed
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[Journal Article] Effect of acetaminophen on progression of renal damage in adenine induced renal failure model rat.2012
Author(s)
Kadowaki D, Sumikawa S, Arimizu K, Taguchi K, Kitamura K, Ishitsuka Y, Narita Y, Irie T, Maruyama T, Otagiri M, Hirata S
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Journal Title
Life Sci.
Volume: 91
Issue: 25-26
Pages: 1304-1308
DOI
Related Report
Peer Reviewed
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