Molecular basis and physiological function of cellular lipid homeostasis in the brain and immune stromal cells

• Project/Area Number: 24390047
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Tohoku University (2015); Yamaguchi University
• Principal Investigator: Owada Yuji 東北大学, 医学(系)研究科(研究院), 教授 (20292211)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Takeo 理化学研究所, 脳科学研究センター, 主任研究員 (30249958)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: FABP / アストロサイト / 脂肪酸 / クッパー細胞 / シナプス / グリオーマ / 脂質ラフト / 脂肪酸結合蛋白質 / 胎盤 / オリゴデンドロサイト

Outline of Final Research Achievements

In this study, we revealed for the first time that alteration of lipid homeostasis in the glial cells affects their response to the external stimuli such as growth factors.
We showed that intracellular lipid binding protein, FABP7, regulates the membrane lipid raft function in astrocytes through the caveolin gene expression. We also showed that glial FABP7 is involved in the control of excitatory synaptic neurotransmission in the medial frontal cortex, and possible associated with the human psychiatric diseases including schizophrenia.

Research Products

• [Journal Article] Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons. (2016)
  • Author(s): Ebrahimi M, Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, Owada Y.
  • Journal Title: Glia Volume: 64(1) Issue: 1 Pages: 48-62
  • DOI: 10.1002/glia.22902
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of fatty acid synthase decreases expression of stemness markers in glioma stem cells. (2016)
  • Author(s): Yasumoto Y., Miyazaki H., Vaidyan L.K., Kagawa Y., Ebrahimi M., Yamamoto Y., Ogata M., Katsuyama Y., Sadahiro H., Suzuki M., & Owada Y.
  • Journal Title: PLoS One Volume: 11(1) Issue: 1 Pages: 11-11
  • DOI: 10.1371/journal.pone.0147717
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid. (2015)
  • Author(s): Pan Y, Scanlon MJ, Owada Y, Yamamoto Y, Porter CJ, Nicolazzo PA.
  • Journal Title: Mol Pharm Volume: 12 Issue: 12 Pages: 4375-4385
  • DOI: 10.1021/acs.molpharmaceut.5b00580
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism. (2015)
  • Author(s): Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagi S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T.
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 16239-16239
  • DOI: 10.1038/srep20268
  • Peer Reviewed
• [Journal Article] Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. (2015)
  • Author(s): Kaczocha M, Glaser ST, Maher T, Clavin B, Hamilton J, O’Rourke J, Rececchi M, Puopolo M, Owada Y, Thanos PK.
  • Journal Title: Mol Pharm Volume: 11 Pages: 52-58
  • DOI: 10.1186/s12990-015-0056-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fatty acid binding protein 3 (FABP3) deficiency does not impact on feto-placental morphometry and fatty acid transporters in mice. (2015)
  • Author(s): Islam A, Owada Y.
  • Journal Title: Biores Comm Volume: 1 Pages: 58-61
  • Peer Reviewed / Open Access
• [Journal Article] The palm-sized cryoprobe system based on refrigerant expansion and boiling and its application to an animal model of epilepsy. (2015)
  • Author(s): Tokiwa T, Zimin L, Ishizuka S, Inoue T, Fujii M, Ishiguro H, Kajigaya H, Owada Y, Suzuki M, Yamakawa T.
  • Journal Title: IEEE Trans Biomed Eng Volume: 62 Issue: 8 Pages: 1949-1958
  • DOI: 10.1109/tbme.2015.2407692
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immunohistochemical analysis of sustentacular cells in the adrenal medulla, carotid body and sympathetic ganglion of mice using an antibody against brain-type fatty acid binding protein (B-FABP). (2015)
  • Author(s): Pakkarato S, Chomphoo S, Kagawa Y, Owada Y, Mothong W, Iamsaard S, Sawatpanich T, Kondo H, Hipkaeo W.
  • Journal Title: J Anat Volume: 226 Issue: 4 Pages: 348-353
  • DOI: 10.1111/joa.12285
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fatty acid binding protein 5 (FABP5) regulates diet-induced obesity (DIO) via GIP secretion from enteroendocrine K-cells in response to fat ingestion. (2015)
  • Author(s): Shibue, K., Yamane, S., Harada, N., Hamasaki, A., Suzuki, K., Joo, E., Iwasaki, K., Nasteska, D., Harada, T., Hayashi, Y., Adachi, Y., Owada, Y., Takayanagi, R. and Inagaki, N.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 308 Issue: 7 Pages: 583-591
  • DOI: 10.1152/ajpendo.00543.2014
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1. (2015)
  • Author(s): Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
  • Journal Title: Glia Volume: 63 Issue: 5 Pages: 780-794
  • DOI: 10.1002/glia.22784
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic differential display analysis reveals decreased expression of PEA-15 and vimentin in FABP7-deficient astrocytes. (2015)
  • Author(s): Ebrahimi, M., Sharifi, K., Islam, A., Miyazaki, H., Yasumoto, Y., Kagawa, Y., Yamamoto, Y., Kitagawa, T., Kuramitsu, Y., Nakamura, K. and Owada, Y.
  • Journal Title: J Proteom Bioinform Volume: 35 Pages: 780-794
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fatty acid binding protein 3 is involved in n-3 and n-6 PUFA transport in mouse trophoblasts. (2014)
  • Author(s): Islam, A., Kagawa, Y., Sharifi, K., Ebrahimi, M., Miyazaki, H., Yasumoto, Y., Kawamura, S., Yamamoto, Y., Sakaguti , S., Sawada, T., Tokuda, N., Sugino, N., Suzuki, R. and Owada, Y.
  • Journal Title: J Nutr Volume: 144 Issue: 10 Pages: 1509-1516
  • DOI: 10.3945/jn.114.197202
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. (2014)
  • Author(s): Shimamoto C, Ohnishi T, Maekawa M, Watanabe A, Ohba H, Arai R, Iwayama Y, Hisano Y, Toyota T, Toyoshima M, Suzuki K, Shirayama Y, Nakamura K, Mori N, Owada Y, Kobayashi T, Yoshikawa T.
  • Journal Title: Hum Mol Genet Volume: 23 Issue: 24 Pages: 6495-6511
  • DOI: 10.1093/hmg/ddu369
  • Peer Reviewed / Open Access
• [Journal Article] Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice. (2014)
  • Author(s): Bando, Y., Yamamoto, M., Sakiyama, K., Inoue, K., Takizawa, S., Owada, Y., Iseki, S., Kondo, H. and Amano, O.
  • Journal Title: J Mol Histol Volume: 45 Issue: 5 Pages: 507-518
  • DOI: 10.1007/s10735-014-9576-1
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acid binding protein 7 regulates phagocytosis and cytokine production in Kupffer cells during liver injury. (2014)
  • Author(s): Miyazaki, H., Sawada, T., Kiyohira, M., Yu, Z., Nakamura, K., Yasumoto, Y., Kagawa, Y., Ebrahimi, M., Islam, A., Sharifi, K., Kawamura, S., Kodama, T., Yamamoto, Y., Adachi, Y., Tokuda, N., Terai, S., Sakaida, I., Ishikawa, T. and Owada, Y.
  • Journal Title: Am J Pathol Volume: 184 Issue: 9 Pages: 2505-2515
  • DOI: 10.1016/j.ajpath.2014.05.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity. (2014)
  • Author(s): Shioda N, Yabuki Y, Kobayashi Y, Onozato M, Owada Y, Fukunaga K.
  • Journal Title: The Journal of Biological Chemistry. Volume: 289(27) Issue: 27 Pages: 18957-18965
  • DOI: 10.1074/jbc.m113.527341
  • Peer Reviewed / Open Access
• [Journal Article] Changes in glutamate concentration, glucose metabolism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans. (2014)
  • Author(s): Nomura, S., Fujii, M., Inoue, T., He, Y., Maruta, Y., Koizumi, H., Suehiro, E., Imoto, H., Ishihara, H., Oka, F., Matsumoto, M.,Owada, Y., Yamakawa, T. and Suzuki, M.
  • Journal Title: Epilepsia. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice. (2014)
  • Author(s): Suzuki, J., Oshima, T., Yoshida, N., Kimura, R., Takata, Y., Owada, Y., Kobayashi, T. and Osumi, N.
  • Journal Title: Neurosci Res. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Spinal cord ischemia/injury. (2014)
  • Author(s): Ishikawa, T., Suzuki, H., Ishikawa, K., Yasuda, S., Matsui, T., Yamamoto, M., Kakeda, T., Yamamoto, S., Owada, Y. and Yaksh, TL.
  • Journal Title: Curr Pharm Design. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Hyperlocomotor activity and stress vulnerability during adulthood induced by social isolation after early weaning are prevented by voluntary running exercise before normal weaning period. (2014)
  • Author(s): Ishikawa, J., Ogawa, Y., Owada, Y. and Ishikawa A.
  • Journal Title: Behavior Brain Res Volume: in press Pages: 197-206
  • DOI: 10.1016/j.bbr.2014.02.007
  • Peer Reviewed
• [Journal Article] nvolvement of bone marrow-derived vascular progenitor cells in neovascularization during follicular development in mice. (2014)
  • Author(s): Kizuka-Shibuya, F., Tokuda, N., Takagi, K., Adachi, Y., Lee, L., Tamura, I., Maekawa, R., Tamura, H., Suzuki, T., Owada, Y. and Sugino N.
  • Journal Title: J Ovarian Res Volume: 7 Issue: 1 Pages: 10-10
  • DOI: 10.1186/1757-2215-7-10
  • Peer Reviewed
• [Journal Article] Fatty acid binding protein 7 as a marker for glioma stem cells. (2013)
  • Author(s): Morihiro, Y., Yasumoto, Y., Koshy, VL., Sadahiro, H., Uchida, T., Inamura, A., Sharifi, K., Ideguchi, M., Nomura, S., Tokuda, N., Kashiwabara, S., Ishii, A., Ikeda, E., Owada , Y. * and Suzuki, M. (* corresp. author)
  • Journal Title: Pathol Int Volume: 63 Issue: 11 Pages: 546-553
  • DOI: 10.1111/pin.12109
  • Peer Reviewed
• [Journal Article] Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells (2013)
  • Author(s): Sharifi K, Yoshikawa
  • Journal Title: Cell and Tissue Research Volume: 354 Issue: 3 Pages: 683-695
  • DOI: 10.1007/s00441-013-1730-7
  • Peer Reviewed
• [Journal Article] The effect of hypothermia therapy in neonatal mice on the cortical laminar disruption following ischemic injury in neonatal mice. (2013)
  • Author(s): Kida, H., Nomura, S., Shinoyama, M., Ideguchi, M., Owada, Y. and Suzuki, M.
  • Journal Title: PLos One Volume: 8 Issue: 7 Pages: e68877-e68877
  • DOI: 10.1371/journal.pone.0068877
  • Peer Reviewed
• [Journal Article] Pathological features of highly invasive glioma stem cells in a mouse xenograft model. (2013)
  • Author(s): Sadahiro, H., Yoshikawa, K., Ideguchi, M., Kajiwara, K., Ishii, A., Ikeda, E., Owada, Y., Yasumoto, Y. and Suzuki, M.
  • Journal Title: Brain Tumor Pathol Volume: 31 Issue: 2 Pages: 77-84
  • DOI: 10.1007/s10014-013-0149-x
  • Peer Reviewed
• [Journal Article] Cooling treatment transiently increases the permeability of brain capillary endothelial cells through translocation of claudin-5. (2013)
  • Author(s): Inamura, A., Adachi, Y., Inoue, T., He, Y., Tokuda, N., Nawata, T., Shirao, S., Nomura, S., Fujii, M., Ikeda, E., Owada, Y. * and Suzuki, M. (* corresp. author)
  • Journal Title: Neurochem Res Volume: 38 Issue: 8 Pages: 1641-1647
  • DOI: 10.1007/s11064-013-1066-4
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective. (2013)
  • Author(s): He, Y.
  • Journal Title: Brain Res. Volume: 1,497 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Epidermal-type FABP is a predictive marker of clinical response to systemic treatment and ultraviolet therapy in psoriatic skin lesions. (2012)
  • Author(s): Miyake, T.
  • Journal Title: J Dermatol Sci Volume: 68 Pages: 199-202
  • Peer Reviewed
• [Journal Article] Reduced size of sebaceous gland and altered sebum lipid composition in mice deficient in the fatty acid-binding protein 5 gene. (2012)
  • Author(s): Sugawara, T., Nemoto, K.
  • Journal Title: Exp Dermatol. Volume: 21 Pages: 543-546
  • Peer Reviewed
• [Journal Article] Involvement of bone marrow-derived vascular progenitor cells in neovascularization during the corpus luteum formation in mice. (2012)
  • Author(s): Kizuka, F., Tokuda, N., Takagi, K., Adachi, Y., Lee, L, Tamura, I., Maekawa, R., Taketani, T., Tamura, H., Suzuki, T., Owada, Y. and Sugino, N.
  • Journal Title: Biol Reprod Volume: 87 Issue: 3 Pages: 1-7
  • DOI: 10.1095/biolreprod.112.099960
  • Peer Reviewed
• [Journal Article] Fatty acid-binding protein 4 (FABP4) and FABP5 modulate cytokine production in the mouse thymic epithelial cells. (2012)
  • Author(s): Adachi, Y. , Hiramatsu, S.
  • Journal Title: Histochem Cell Biol. Volume: 138 Pages: 397-406
  • Peer Reviewed
• [Journal Article] The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse. (2012)
  • Author(s): Miho Matsumata, Nobuyuki Sakayori, Motoko Maekawa, Yuji Owada, Takeo Yoshikawa, Noriko Osumi
  • Journal Title: Stem Cells Volume: 30(7) Issue: 7 Pages: 1532-1543
  • DOI: 10.1002/stem.1124
  • Peer Reviewed
• [Presentation] Ultimate fate of mouse small intestinal intra-epithelial lumphocytes. (2016)
  • Author(s): 尾形雅君、勝山裕、香川慶輝、伊藤恒敏、大和田祐二
  • Organizer: 第121回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 郡山市 ビッグパレットふくしま
  • Year and Date: 2016-03-30
• [Presentation] 脂肪酸結合蛋白質FABP7の細胞内局在変化がCaveolin-1遺伝子発現に及ぼす影響 (2016)
  • Author(s): 香川慶輝、大和田祐二
  • Organizer: 第121回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 郡山市 ビッグパレットふくしま
  • Year and Date: 2016-03-30
• [Presentation] 視床下部グリアに発現するFABP7のレプチン感受性と摂食行動における機能 (2016)
  • Author(s): 安本有希、大和田祐二
  • Organizer: 第121回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 郡山市 ビッグパレットふくしま
  • Year and Date: 2016-03-29
• [Presentation] 高脂肪食摂取肥満マウスにおける肝マクロファージのFABP7の機能的役割の検討 (2016)
  • Author(s): 宮崎啓史、児玉孝憲、澤田知夫、大和田祐二
  • Organizer: 第121回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 郡山市 ビッグパレットふくしま
  • Year and Date: 2016-03-29
• [Presentation] 脂肪酸結合タンパク質FABP3による抑制性介在神経制御機構 (2015)
  • Author(s): 山本由似、澤田知夫、徳田信子、大和田祐二
  • Organizer: 第70回 日本解剖学会 中国・四国支部学術集会
  • Place of Presentation: 松山市 愛媛大学南加記念ホール
  • Year and Date: 2015-10-25
• [Presentation] マクロファージM1/M2分化におけるFABPの関与 (2015)
  • Author(s): 児玉孝憲、宮崎啓史、澤田知夫、大和田祐二、徳田信子
  • Organizer: 第70回 日本解剖学会 中国・四国支部学術集会
  • Place of Presentation: 松山市 愛媛大学南加記念ホール
  • Year and Date: 2015-10-24
• [Presentation] FABP3遺伝子欠損マウスの認知・情動行動異常とメチオニンによる改善作用 (2015)
  • Author(s): 山本 由似、木田 裕之、美津島 大、福永 浩司、大和田 祐二
  • Organizer: 第37回日本生物学的精神医学会・第45回日本神経精神薬理学会（合同年会)
  • Place of Presentation: 東京都 タワーホール船堀
  • Year and Date: 2015-09-25
• [Presentation] 腸上皮細胞間リンパ球（IEL）の活性化および細胞死の形態学的解析 (2015)
  • Author(s): 尾形雅君、大和田祐二、伊藤恒敏
  • Organizer: 第61回 日本解剖学会 東北・北海道連合支部会学術集会
  • Place of Presentation: 盛岡市 観光文化交流センター
  • Year and Date: 2015-08-30
• [Presentation] Epidermal fatty acid binding protein によるパイエル板M細胞腸管内抗原取り込み機構制御 (2015)
  • Author(s): 鈴木良地、志村洋一郎、徳田信子、大和田祐二、阿部寛
  • Organizer: 第61回 日本解剖学会 東北・北海道連合支部会学術集会
  • Place of Presentation: 盛岡市 観光文化交流センター
  • Year and Date: 2015-08-30
• [Presentation] アンモン角錐体ニューロンと歯状回顆粒ニューロンの前駆細胞は発生過程で混在する (2015)
  • Author(s): 勝山裕、杉山拓、大隅典子、大和田祐二
  • Organizer: 第61回 日本解剖学会 東北・北海道連合支部会学術集会
  • Place of Presentation: 盛岡市 観光文化交流センター
  • Year and Date: 2015-08-29
• [Presentation] 脂肪酸結合タンパク質による細胞膜微小ドメイン制御とその意義 (2015)
  • Author(s): 大和田祐二
  • Organizer: 第11回 必須脂肪酸と健康 研究会
  • Place of Presentation: 京都府 サントリーワールドリサーチセンター
  • Year and Date: 2015-08-07
• [Presentation] FABP7 is an epigenetic modulator of caveolin-1 gene expression in astrocytes. (2015)
  • Author(s): 香川慶輝、大和田祐二
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸市 神戸国際会議場
  • Year and Date: 2015-07-30
• [Presentation] Possible role of hypothalamic FABP7 in the control of glial cell proliferation and leptin sensitivity (2015)
  • Author(s): 安本有希、大和田祐二
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸市 神戸国際会議場
  • Year and Date: 2015-07-29
• [Presentation] Possible role of hypothalamic FABP7 in the control of glial cell proliferation and leptin sensitivity (2015)
  • Author(s): Yuki Yasumoto, Yuji Owada
  • Organizer: Tools and Technologies, Frontiers of Brain Science, Tohoku Forum for Creativity
  • Place of Presentation: 仙台市 東京エレクトロンハウス
  • Year and Date: 2015-07-25
• [Presentation] 脂肪酸結合タンパク質によるグリア細胞の膜微小ドメイン制御 (2015)
  • Author(s): 大和田祐二
  • Organizer: 第66回超微形態懇話会
  • Place of Presentation: 仙台市 艮陵会館
  • Year and Date: 2015-07-16
  • Invited
• [Presentation] 脂肪酸結合蛋白質の研究から疾患を理解する (2015)
  • Author(s): 大和田祐二
  • Organizer: 第100回東北医学会総会
  • Place of Presentation: 仙台市 艮陵会館
  • Year and Date: 2015-05-15
  • Invited
• [Presentation] 脂肪酸タンパク質(FABP)を通して、栄養と精神疾患の関連を理解する (2015)
  • Author(s): 大和田祐二
  • Organizer: 第11回日本疲労学会総会・学術集会
  • Place of Presentation: 山口市 山口県総合保健会館
  • Year and Date: 2015-05-15
  • Invited
• [Presentation] FABP3は多価不飽和脂肪酸の栄養膜細胞通過を制御する (2015)
  • Author(s): 澤田 知夫、Ariful Islam、鈴木 良地、大和田 祐二
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-22
• [Presentation] 脳型脂肪酸結合蛋白質（FABP7)はマウスcaveolin-1遺伝子発現をエピジェネティックに制御する (2015)
  • Author(s): 香川 慶輝、向後 寛、岸 博子、小林 誠、藤本 豊士、大和田 祐二
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] メチオニンはFABP3遺伝子欠損マウスにおけるGAD67の発現上昇と行動異常を改善する (2015)
  • Author(s): 山本 由似、木田 裕之、美津島 大、大和田 祐二
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] Role of astrocyte-expressed FABP7 on morphology and synapse Formation of cortical neurons (2015)
  • Author(s): Ebrahimi, M., Kida, H., Mitsushima, D. and Owada, Y.
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] 視床下部FABP7はグリアの分裂を制御し、摂食調節に関与する (2015)
  • Author(s): 安本 有希、宮崎 啓史、坂井 基樹、大和田 祐二
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] 高脂肪食誘導脂肪性肝疾患モデルにおけるKupffer細胞のFABP7の機能的役割の検討 (2015)
  • Author(s): 宮崎 啓史、児玉 孝憲、河村 沙樹、澤田 知夫、大和田 祐二
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] マウスKupffer細胞におけるFABP7発現調節メカニズムの検討 (2015)
  • Author(s): 児玉 孝憲、宮崎 啓史、河村 沙樹、澤田 知夫、徳田 信子、大和田 祐二
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] FABP3 遺伝子欠損マウスにおけるGAD67 の発現上昇と行動異常のメチオニン投与 による改善作用 (2015)
  • Author(s): 山本 由似、木田 裕之、美津島 大、福永 浩司、大和田 祐二
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-19
• [Presentation] Epigenetic modification of caveolin-1 gene expression by fatty acid binding protein 7 (2014)
  • Author(s): Kagawa, Y. and Owada, Y.
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-11-26
• [Presentation] Localization of FABP3 in the mouse cingulate cortex and its possible role in the regulation of inhibitory neurons. (2014)
  • Author(s): Yamamoto, Y., Sharifi, K., Islam, A., Ebrahimi, M., Yasumoto, Y.,Miyazaki, H., Kagawa, Y., Sawada, T., Tokuda, N., Fukunaga, K. and Owada, Y.
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2014-11-18
• [Presentation] Role of astrocytic FABP7 in medial prefrontal cortex (mPFC) as a regulator of mouse emotional behavior. (2014)
  • Author(s): Ebrahimi, M., Sharifi, K., Kagawa, Y., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto, Y., Sawada, T., Yoshikawa, T. and Owada, Y.
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2014-11-17
• [Presentation] FABP7 regulates LPS-induced TNF-a production through lipid raft formation in the astrocytes (2013)
  • Author(s): Kagawa, Y.
  • Organizer: 第118回日本解剖学会総会・全国学術総会
  • Place of Presentation: かがわ国際会議場(高松市)
  • Year and Date: 2013-03-29
• [Presentation] Control of neuronal dendritic formation by brain-type fatty acid binding protein (FABP7) (2012)
  • Author(s): Ebrahimi, M.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans(USA)
  • Year and Date: 2012-10-15
• [Presentation] FABP7 is involved in epigenetic modification in astrocytes.
  • Author(s): Kagawa, Y.
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸国際会議場（神戸）
• [Presentation] Fatty acid binding protein 3 (FABP3) regulates cognitive function and anxiety behaviors.
  • Author(s): Yamamoto, Y.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego(USA)
• [Remarks] 山口大学大学院医学系研究科 器官解剖学分野研究室HP
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~org-anat/
• [Patent(Industrial Property Rights)] 難聴が生じにくいモデル動物 (2013)
  • Inventor(s): 鈴木淳、大隅典子、高田雄介、大和田祐二
  • Industrial Property Rights Holder: 東北大学・山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-09-13
  • Overseas