| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
Phogrin, a member of receptor protein tyrosine phosphatases, primarily localizes on secretory granules (SGs) in a variety of neuroendocrine cells including pancreatic β-cells, and has some supportive roles in SGs formation and cell growth. We analyze its function with use of newly developed imaging method and of gene-targeting mice. Our data show an evidence suggesting that at the plasma membrane phogrin participates in molecular interactions with insulin receptors to regulate IRS2 protein stability and in turn glucose-promoted pancreatic β-cell growth. We further showed that phogrin supports PTP1B activity to achieve an overall regulation of glucose-stimulated insulin signaling.
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