Stabilizing endocrine cell function by phogrin.
| Project/Area Number |
24390050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Gunma University |
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Principal Investigator |
TORII SEIJI 群馬大学, 生体調節研究所, 准教授 (40312904)
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| Co-Investigator(Renkei-kenkyūsha) |
GOMI Hiroshi 日本大学, 生物資源科学部, 教授 (90293240)
NAMEKI Nobukazu 群馬大学, 工学研究科, 准教授 (80302959)
MOGAMI Hideo 浜松大学, 健康科学部, 教授 (90311604)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | ペプチドホルモン / 分泌顆粒 / インスリン / オートクライン / チロシンホスファターゼ / 膵島 / 細胞内輸送 / 細胞内分解 |
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| Outline of Final Research Achievements |
Phogrin, a member of receptor protein tyrosine phosphatases, primarily localizes on secretory granules (SGs) in a variety of neuroendocrine cells including pancreatic β-cells, and has some supportive roles in SGs formation and cell growth. We analyze its function with use of newly developed imaging method and of gene-targeting mice. Our data show an evidence suggesting that at the plasma membrane phogrin participates in molecular interactions with insulin receptors to regulate IRS2 protein stability and in turn glucose-promoted pancreatic β-cell growth. We further showed that phogrin supports PTP1B activity to achieve an overall regulation of glucose-stimulated insulin signaling.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] VAMP7 regulates autophagy to maintain mitochondrial homeostasis and to control insulin secretion in pancreatic β-cells.2016
Author(s)
Aoyagi K, Ohara-Imaizumi M, Itakura M, Torii S, Akimoto Y, Nishiwaki C, Nakamichi Y, Kishimoto T, Kawakami H, Harada A, Takahashi M, Nagamatsu S
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Journal Title
NAID
Related Report
Peer Reviewed
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