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Exploration of the mechanisms underlying normal glomerular filtration function and its pathologic disruption via the TRPC6-slit diaphragm protein complex-mediated mechano-signaling

Research Project

Project/Area Number 24390054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General physiology
Research InstitutionFukuoka University

Principal Investigator

Inoue Ryuji  福岡大学, 医学部, 教授 (30232573)

Co-Investigator(Renkei-kenkyūsha) MORI Masayuki  京都大学, 工学部, 准教授 (80342640)
Research Collaborator KURAHARA Lin-Hai  
ICHIKAWA Jun  
HU Yaopeng  
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords腎スリット膜複合体 / 機械刺激情報伝達 / TRP蛋白質 / Ca情報伝達 / 糸球体硬化症 / スリット膜複合体 / 受容体刺激・機械刺激情報伝達 / 足細胞 / 濾過機能 / PKGリン酸化 / 受容体刺激情報伝達
Outline of Final Research Achievements

To explore the precise physiological and pathophysiological implications of the slit diaphragm complex including a canonical member of transient receptor potential (TRP) channel TRPC6, in regulating the glomerular filtration function, we carried out detailed analysis with a minimally constructed slit-diaphragm-protein expression system and a ‘pseudo-slit diaphragm’ formed by podocytes on an artificial filter membrane. The results have suggested that the complex of TRPC6-podocin-(nephrin)-cytoskeletal actin mediates Ca influx into renal podocytes in response to receptor and mechanical stimuli, thereby effectively regulating the glomerular barrier function, and that conditions causing the excess of these Ca responses such as mutations associated with familial focal glomerulosclerosis and renal inflammation, may lead to disruption of the barrier and subsequent proteinuria.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (50 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (26 results) (of which Int'l Joint Research: 3 results,  Invited: 13 results) Book (5 results) Remarks (4 results)

  • [Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds2016

    • Author(s)
      S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
    • Journal Title

      Mol Pharmacol

      Volume: 89(3) Issue: 3 Pages: 348-363

    • DOI

      10.1124/mol.115.102863

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] "TRP inflammation" relationship in cardiovascular system.2015

    • Author(s)
      Numata T, Takahashi K, Inoue R
    • Journal Title

      Semin Immunopathol.

      Volume: 印刷中 Issue: 3 Pages: 339-356

    • DOI

      10.1007/s00281-015-0536-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway2015

    • Author(s)
      Masayuki X Mori, Kyohei Itsuki, Hideharu Hase, Seishirou Sawamura, Tatsuki Kurokawa, Yasuo Mori, Ryuji Inoue
    • Journal Title

      Frontiers in Pharmacology

      Volume: 6 Pages: 22-22

    • DOI

      10.3389/fphar.2015.00022

    • NAID

      120005663278

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal myofibroblast TRPC6 channel may contribute to stenotic fibrosis in Crohn’s disease2015

    • Author(s)
      Lin Hai Kurahara, Miho Sumiyoshi, Kunihiko Aoyagi, Kyoko Nakajima, Midori Nakagawa, Keizo Hiraishi, Ryuji Inoue
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 21(3) Issue: 3 Pages: 496-506

    • DOI

      10.1097/mib.0000000000000295

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway.2015

    • Author(s)
      Masayuki X Mori, Kyohei Itsuki, Hideharu Hase, Seishirou Sawamura, Tatsuki Kurokawa, Yasuo Mori, Ryuji Inoue
    • Journal Title

      Front Pharmacol.

      Volume: 6 Pages: 1-5

    • NAID

      120005663278

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New Experimental Trends for Phosphoinositides Research on Ion Transporter/Channel Regulation2014

    • Author(s)
      Masayuki X. Mori, Ryuji Inoue
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 126 Issue: 3 Pages: 186-197

    • DOI

      10.1254/jphs.14R14CP

    • NAID

      130004704282

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BDNF induces sustained intracellular Ca2+ elevation through the upregulation of surface TRPC3 channels in rodent microglia2014

    • Author(s)
      Mizoguchi Y, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289(26) Issue: 26 Pages: 18549-18555

    • DOI

      10.1074/jbc.m114.555334

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels2014

    • Author(s)
      Kyohei Itsuki, Yuko Imai, Hideharu Hase, Yasushi Okamura, Ryuji Inoue, and Masayuki Mori
    • Journal Title

      Journal of General Physiology

      Volume: 143(2) Issue: 2 Pages: 183-201

    • DOI

      10.1085/jgp.201311033

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New therapeutic insights for chronic kidney disease provided by podocytology2014

    • Author(s)
      井上隆司*、淺沼克彦、関 卓人、長瀬美樹、長船健二
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 143 Issue: 1 Pages: 27-33

    • DOI

      10.1254/fpj.143.27

    • NAID

      130004827686

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ポドサイトを標的とした基礎研究の新展開-Podocytologyがひらく新しい慢性腎臓病治療戦略-2014

    • Author(s)
      井上隆司、淺沼克彦、関卓人、長瀬美樹、長船健二
    • Journal Title

      日本薬理学会誌(Folia Pharmacol Jpn.)

      Volume: 143(1) Pages: 27-33

    • NAID

      130004827686

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II2013

    • Author(s)
      Juan Shi, Naomi Geshi, Shinichi Takahashi, Shigeki Kiyonaka, Jun Ichikawa, Yaopeng Hu, Yasuo Mori, Yushi Ito, Ryuji Inoue
    • Journal Title

      Journal of Physiology (London)

      Volume: 591(11) Issue: 11 Pages: 2851-2866

    • DOI

      10.1113/jphysiol.2013.251249

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner2013

    • Author(s)
      Yuki Nakamura, Xiuyu Shi, Tomohiro Numata, Yasuo Mori, Ryuji Inoue, Christoph Lossin, Tallie Z. Baram, Shinichi Hirose
    • Journal Title

      PLoS One

      Volume: 8(12) Issue: 12 Pages: e80376-e80376

    • DOI

      10.1371/journal.pone.0080376

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of TRPC1-mediated Ca2+ entry in decidualization of human endometrial stromal cells2012

    • Author(s)
      Yasuhiro Kawarabayashi, Lin Hai, Akira Honda, Shinji Horiuchi, Hiroshi Tsujioka, Jun Ichikawa, Ryuji Inoue
    • Journal Title

      Molecular Endocrinology

      Volume: 26(5) Issue: 5 Pages: 846-858

    • DOI

      10.1210/me.2011-1259

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-sensing phosphatase reveals temporal regulation of TRPC3/C6/C7 channels by membrane phosphoinositides.2012

    • Author(s)
      Itsuki K, Imai Y, Okamura Y, Abe K, Inoue R, Mori MX.
    • Journal Title

      Channels

      Volume: 6 Issue: 3 Pages: 206-209

    • DOI

      10.4161/chan.20883

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A self-limiting regulation of TRPC3/C6/C7 channels coupled with PI(4,5)P2-diacylglycerol signalling.2011

    • Author(s)
      Imai Y, Itsuki K, Okamura Y, Inoue R, Mori MX
    • Journal Title

      The Journal of Physiology

      Volume: 590 Issue: 5 Pages: 1101-1119

    • DOI

      10.1113/jphysiol.2011.221358

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] PIP2による平滑筋受容体活性化Caチャネル制御のシミュレーション解析2016

    • Author(s)
      井上隆司
    • Organizer
      シンポジウム「平滑筋の生理と機能」
    • Place of Presentation
      ウェスティンナゴヤキャッスル、名古屋
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Simulation-based study of PIP2-meditated regulation of TRP channels based on voltage-sensing phosphatase and FRET measurements2015

    • Author(s)
      Inoue R, Hu Y, Ichikawa J, Kurahara LH, Numata T
    • Organizer
      Symposium VIII “The roles of TRP channels in cardiovascular system”, The 67th Annual Meeting of Korean Physiological Society
    • Place of Presentation
      Moam Hall, Pusan National University Hospital, Busan, Korea
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic regulation of TRPC and TRPM4 channels by endogenous PIP2 level investigated by voltage-sensing phosphatase and FRET2015

    • Author(s)
      Inoue R
    • Organizer
      Keynote lecture, the 50th Annual Congress of the Brazilian Society of Physiology (SBFis 2015)
    • Place of Presentation
      Aquas Lindoia, San Paulo, Brazil
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A FRET- and simulation-based study on the PIP2-mediated regulation of TRPC3/C6/C7 subfamily channels2015

    • Author(s)
      Inoue R, Itsuki K, Imai U, Okamura Y, Mori MX
    • Organizer
      Symposium “Multicellular Inputs Regulating Muscle Excitability”
    • Place of Presentation
      Granlibakken, Lake Tahoe, California, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Involvement of podocin on abnormal receptor-response and mechanosensitivity of mutant TRPC6 channels associated with familial focal segmental glomerulosclerosis (FSGS).2015

    • Author(s)
      Ichikawa J., Inoue R.
    • Organizer
      The 92th annual meeting of Physiological Society of Japan
    • Place of Presentation
      Kobe
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pathogenic activation of TRPC6 channel associated with familial focal segmental glomerulosclerosis (FSGS) mutations may be counteracted by the cGMP/PKG pathway through interaction with actin cytoskeleton.2015

    • Author(s)
      Ichikawa J, Inoue R.
    • Organizer
      The 88th annual meeting of Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Post-translational mechanisms for cardiovascular TRPC6 channel regulation and their physiological/pathophysiological implications.2014

    • Author(s)
      Inoue R
    • Organizer
      the 11th International Symposium on Resistance Arteries.
    • Place of Presentation
      Banff, Canada
    • Year and Date
      2014-09-07 – 2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mutagenic and post-translational modifications of the mechanosensitivity of reno-cardiovascular TRPC6 channel2014

    • Author(s)
      Inoue, R., Jian, Z., Ichikawa, J., Nakagawa, M., Kurahara, L., Hu Y.
    • Organizer
      The 2nd International Symposium of Mechanobiology
    • Place of Presentation
      Okayama
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Druggability of TRP channels in cardiovascular disease.2013

    • Author(s)
      Ryuji Inoue
    • Organizer
      Collaboration Symposium with the Japanese Pharmacological Society. The 90<th> Annual meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo(招待講演)
    • Year and Date
      2013-05-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pathophysiological mechanism involved in mechanotransduction at podocyte TRPC6 channel signaling complex. Symposium 6 "New therapeutic insights for chronic kidney disease provided by the podocytology.2013

    • Author(s)
      Ryuji Inoue, Jun Ichikawa, Midori Nakagawa
    • Organizer
      The 86^<th> Annual Meeting of the Japanese Pharmacological Society. Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2013-05-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] TRPM4チャネル発現増加による不整脈誘発機構の検討。2012

    • Author(s)
      胡耀鵬,段玉斌、倉原琳、市川純、井上隆司
    • Organizer
      第63回西日本生理学会
    • Place of Presentation
      大分
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] TRPM4チャネルの催不整脈性の再検討2012

    • Author(s)
      Hu Yaopeng, Duan Yubin, 市川純, 倉原琳, 井上隆司
    • Organizer
      第8回TRPチャネル研究会(生理研研究会)
    • Place of Presentation
      岡崎
    • Year and Date
      2012-06-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト子宮内膜間質細胞の脱落膜化過程におけるTRPC1の役割2012

    • Author(s)
      瓦林靖広、倉原(海)琳、本田啓、市川純、井上隆司
    • Organizer
      第8回TRPチャネル研究会(生理研研究会)
    • Place of Presentation
      岡崎
    • Year and Date
      2012-06-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Arrhythmogenic significance of TRPM4 channel evaluated by a new experimental approach.2012

    • Author(s)
      Ryuji Inoue, Hu Yaopeng, Yubin Duan, Lin Hai, Jun Ichikawa
    • Organizer
      International Conference of Physiological Sciences 2012, Symposium 3
    • Place of Presentation
      Suzhou, China(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] TRPC6チャネルを巡る機械刺激受容伝達異常と家族性腎糸球体硬化症。2012

    • Author(s)
      井上隆司、市川純、中川緑
    • Organizer
      生理研研究会「イオンチャネル・トランスポーターと心血管機能:細胞機能の分子機序とその統合的理解」
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] TRP蛋白質を標的とした新しい心血管病治療薬創出の可能性と問題点

    • Author(s)
      井上隆司
    • Organizer
      和歌山県立医科大学セミナー
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ca2+依存性カルモジュリンキナーゼIIによるリン酸化を介した心血管TRPC6チャネル制御の分子基盤

    • Author(s)
      井上隆司
    • Organizer
      第9回TRPチャネル研究会(生理研研究会)
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内Ca動態を介した心血管機能調節とその異常 -TRPチャネルを巡る話題を中心にー

    • Author(s)
      井上隆司
    • Organizer
      島根大学医学部セミナー
    • Place of Presentation
      出雲
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A new experimental approach reveals a high Ca2+ sensitivity of TRPM4 channel and its significant implications in arrhythmogenicity.

    • Author(s)
      Ryuji Inoue, Yaopeng Hu, Yubin Duan, Kurahara Lin, Jun Ichikawa
    • Organizer
      The 37th Congress of the International Union of Physiological Sciences (IUPS2013)
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] ホスホイノシチド代謝に連関した平滑筋機能制御:最近の動向

    • Author(s)
      井上隆司
    • Organizer
      第55回日本平滑筋学会シンポジウム
    • Place of Presentation
      旭川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心血管障害とTRPチャネル‐治療標的としての可能性

    • Author(s)
      井上隆司
    • Organizer
      生体機能と創薬シンポジウム2013
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Arrhythmic contribution of upregulated TRPM4 channel activity in stressed cardiomyocytes

    • Author(s)
      Ryuji Inoue, Yaopeng Hu, Yubin Duan, Kurahara Lin, Jun Ichikawa
    • Organizer
      The 11th Korea-Japan Joint Symposium of Brain Sciences, Cardiac and Smooth Muscle Sciences
    • Place of Presentation
      Hamamatsu
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新しい不整脈基質候補分子TRPM4チャネルの催不整脈性の定量的検討

    • Author(s)
      井上隆司
    • Organizer
      京都大学学際融合教育研究推進センター先端医工学研究ユニット交流会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新しい形質膜Ca2+ チャネル群TRP蛋白質を標的とした創薬可能性とその問題点

    • Author(s)
      井上隆司
    • Organizer
      第33回日本眼薬理学会(
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Reno-pathogenic mutations and PKG-mediated phosphorylation alter

    • Author(s)
      Ryuji Inoue, Jun Ichikawa, Midori Nakagawa, Rin Kurahara, Yaopeng Hu
    • Organizer
      KPS-PSJ symposium (FAOPS Joint Symposium) “Mechanosensitive regulation of biological function: update”
    • Place of Presentation
      Kagoshima
    • Related Report
      2013 Annual Research Report
  • [Presentation] Altered PIP2 sensitivity may underlie the arrhythmogenicity of mutant TRPM4 channel

    • Author(s)
      Ryuji Inoue, Hu Yaopeng, Yasushi Okamura, Masayuki X Mori.
    • Organizer
      第86回日本薬理学会総会・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] TRPチャネルを介した心不整脈発生機序2014

    • Author(s)
      井上隆司、胡 耀鵬
    • Total Pages
      6
    • Publisher
      実験医学
    • Related Report
      2014 Annual Research Report
  • [Book] 眼科領域におけるTRPチャネルの生理・病態生理的役割2014

    • Author(s)
      井上隆司
    • Total Pages
      17
    • Publisher
      日本眼薬理学会
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学 32巻4号 「TRPチャネルを介した心不整脈発生機序」2014

    • Author(s)
      井上隆司、胡耀鵬
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] The pathophysiological implications of TRP channels in cardiac arrhythmia. In:"Cardiac Arrhythmias - New Considerations-".2012

    • Author(s)
      Ryuji Inoue, Yubin Duan, Yaopeng Hu, Jun Ichikawa.
    • Total Pages
      24
    • Publisher
      InTech Review-Open Access Publisher, ISBN 978-953-51-0126-0. Ed.. Francisco R. Breijo-Marquez.
    • Related Report
      2012 Annual Research Report
  • [Book] Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation. In: "Mechanosensitivity in Cells and Tissues. Volume, No 6. -Mechanically Gated Channels and their regulation-"2012

    • Author(s)
      Ryuji Inoue. Yaopeng Hu, Yubin Duan, Kyohei Itsuki
    • Total Pages
      20
    • Publisher
      Springer Verlag, Germany, eds. A. Kamkin & Kiseleva, Chapter 10, pp.281- 300,
    • Related Report
      2012 Annual Research Report
  • [Remarks] 個人ホームページ(福岡大学医学部生理学教室:井上隆司)

    • URL

      http://www.med.fukuoka-u.ac.jp/physiol/index-j.htm

    • Related Report
      2015 Annual Research Report
  • [Remarks] 福岡大学医学部生理学・個人HP

    • URL

      http://www.med.fukuoka-u.ac.jp/physiol/study2.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 福岡大学医学部生理学・大学院医学研究科細胞分子制御学HP

    • URL

      http://www.med.fukuoka-u.ac.jp/physiol/index-j.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.fukuoka-u.ac.jp/physiol/index-j.htm

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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