| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
The hypothalamic suprachiasamtic nucleus (SCN), the site of the central circadian clock of mammals, exhibits circadian rhythms in clock gene expression and neuronal activities from the late fetal period through the end of life. We found that the neonatal SCN is clock gene Cry independent while Cry is indispensable for circadian rhythm expression in the adolescent SCN. Molecular and cellular mechanisms for coherent circadian rhythm expression in the SCN was examined using molecular and pharmacological techniques such as multiple bioluminescent reporters, co-culture of knockout and wild type SCNs. We found that peptidergic signals are critically involved in the CRY independent integration of cellular circadian rhythms, and continuous light exposure during postnatal development compensates the disorganization of behavior rhythms due to CRY deficiency.
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