Clock gene functions in the development of circadian system and effects of environmental factors
| Project/Area Number |
24390055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
Honma Sato 北海道大学, 医学(系)研究科(研究院), 特任教授 (20142713)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRATA Yoshihiro 北海道大学, 大学院医学研究科, 特任助教 (90399824)
NAKAMURA Tomoko (YOSHIKAWA Tomoko) 北海道大学, 大学院医学研究科, 特任助教 (30451397)
TOKUDA Isao 立命館大学, 理工学部, 教授 (00261389)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 生体リズム / 視交叉上核 / 時計遺伝子 / イメージング / ネットワーク |
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| Outline of Final Research Achievements |
The hypothalamic suprachiasamtic nucleus (SCN), the site of the central circadian clock of mammals, exhibits circadian rhythms in clock gene expression and neuronal activities from the late fetal period through the end of life. We found that the neonatal SCN is clock gene Cry independent while Cry is indispensable for circadian rhythm expression in the adolescent SCN. Molecular and cellular mechanisms for coherent circadian rhythm expression in the SCN was examined using molecular and pharmacological techniques such as multiple bioluminescent reporters, co-culture of knockout and wild type SCNs. We found that peptidergic signals are critically involved in the CRY independent integration of cellular circadian rhythms, and continuous light exposure during postnatal development compensates the disorganization of behavior rhythms due to CRY deficiency.
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Report
(5 results)
Research Products
(68 results)
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[Journal Article] Coupling controls synchrony of clock cells in development and knockouts2015
Author(s)
Tokuda, I., Ono, D., Ananthasubramaniam, B., Honma, S., Honma, K., and Herzel, H.
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Journal Title
Biophysical Journal
Volume: 109
Issue: 10
Pages: 2159-2170
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms.2014
Author(s)
Kon N, Yoshikawa T, Honma S, Yamagata Y, Yoshitane H, Shimizu K, Sugiyama Y, Hara C, Kameshita I, Honma K, Fukada Y.
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Journal Title
Genes Dev
Volume: 28
Issue: 10
Pages: 1101-1110
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 睡眠覚醒リズムの中枢機構2014
Author(s)
本間さと
Organizer
日本睡眠学会第31回定期学術集会
Place of Presentation
あわぎんホール、徳島
Year and Date
2014-07-03 – 2014-07-04
Related Report
Invited
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[Book] Biological Clocks2015
Author(s)
Honma S, Ono D, Enoki R, Yoshikawa T, Kuroda S and Honma K
Total Pages
253
Publisher
Hokkaido University Press
Related Report
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