Role of the ventromedial hypothalamus in the regulation of food intake and metabolism.
| Project/Area Number |
24390058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Shiki 生理学研究所, 発達生理学研究系, 助教 (40342919)
TODA Chitoku 生理学研究所, 発達生理学研究系, 特別協力研究員 (70571199)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 視床下部 / 代謝 / 摂食 / レプチン / DREADD |
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| Outline of Final Research Achievements |
We examined the role of the ventromedial hypothalamic (VMH) neuron in the control of metabolism in mice by using Hyperinsulinemic-euglycemic clamp and 2DG method. We also examined the effect of preferential activation of Ad4BP neuron in the VMH on food intake and metabolism. Leptin increased glucose uptake in muscle and inhibited glucose production in the liver by enhancing insulin sensitivity. Activation of Ad4BP neuron in the VMH by DREADD inhibited food intake and increased insulin sensitivity in skeletal muscle and the liver. These results thus suggested that VMH neurons play an important role in insulin sensitivity in skeletal muscle and the liver as well as food intake.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.2014
Author(s)
Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T.
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Journal Title
Diabetologia
Volume: 57
Issue: 4
Pages: 819-831
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.2013
Author(s)
Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho EA, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S, Minokoshi Y.
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Journal Title
Diabetes
Volume: 62
Issue: 7
Pages: 2295-2307
DOI
Related Report
Peer Reviewed
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