Functional of GPR143, a novel G protein-coupled receptor for L-DOPA
| Project/Area Number |
24390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
GOSHIMA Yoshio 横浜市立大学, 医学(系)研究科(研究院), 教授 (00153750)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Fumio 横浜市立大学, 医学部, 准教授 (10262023)
OIKAWA Masato 横浜市立大学, 生命ナノシステム科学研究科, 教授 (70273571)
SUZUKI Tsutomu 星薬科大学, 薬学部, 教授 (90130757)
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| Co-Investigator(Renkei-kenkyūsha) |
OKABE Takayoshi 東京大学, 創薬機構, 特任教授 (80570671)
FUKUNISHI Yoshifumi 独立行政法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究チーム長 (60357895)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | ドーパ / 眼白子症 / 神経伝達物質 / G蛋白質連関型受容体 / OA-1 / OAL / Gタンパク質連関型受容体 / 孤束核 / 圧受容器反射 / 免疫組織化学 / パーキンソン病 / 拮抗薬 |
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| Outline of Final Research Achievements |
L-DOPA (DOPA) is generally considered to alleviate the symptoms of Parkinson’s disease by its conversion to dopamine. We have proposed that DOPA is itself a neurotransmitter. However, specific receptors for DOPA have not been identified. In this study, we demonstrated that GPR143, the gene product of ocular albinism 1 (OA1), mediated DOPA-induced depressor and bradycardic response in the nucleus tractus solitarii. OA1 was expressed not only in the central nervous system such as substantia nigra, striatum, olfactory bulb, hypothalamic median eminence and lower brain stem, but also in peripheral tissues including liver, kidney, lung and spleen. These findings further add to the evidence for a neurotransmitter role for DOPA.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Expression of ocular albinism 1 (OA1),3,4-dihydroxy-L-phenylalanine(DOPA) receptor, in both neuronal and non-neuronal organs.2015
Author(s)
Fukuda N, Naito S, Masukawa D, Kaneda M, Miyamoto H, Abe T, Yamashita Y, Endo I, Nakamura F, Goshima Y
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Journal Title
Brain Research
Volume: 1602
Pages: 62-74
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.2014
Author(s)
Hiroshima Y, Miyamoto H, Nakamura F, Masukawa D, Yamamoto T, Muraoka H, Kamiya M, Yamashita N, Suzuki T, Matsuzaki S, Endo I, Goshima Y
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Journal Title
British Journal of Pharmacology
Volume: 171
Issue: 2
Pages: 403-414
DOI
Related Report
Peer Reviewed
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