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Functional of GPR143, a novel G protein-coupled receptor for L-DOPA

Research Project

Project/Area Number 24390062
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General pharmacology
Research InstitutionYokohama City University

Principal Investigator

GOSHIMA Yoshio  横浜市立大学, 医学(系)研究科(研究院), 教授 (00153750)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Fumio  横浜市立大学, 医学部, 准教授 (10262023)
OIKAWA Masato  横浜市立大学, 生命ナノシステム科学研究科, 教授 (70273571)
SUZUKI Tsutomu  星薬科大学, 薬学部, 教授 (90130757)
Co-Investigator(Renkei-kenkyūsha) OKABE Takayoshi  東京大学, 創薬機構, 特任教授 (80570671)
FUKUNISHI Yoshifumi  独立行政法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究チーム長 (60357895)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsドーパ / 眼白子症 / 神経伝達物質 / G蛋白質連関型受容体 / OA-1 / OAL / Gタンパク質連関型受容体 / 孤束核 / 圧受容器反射 / 免疫組織化学 / パーキンソン病 / 拮抗薬
Outline of Final Research Achievements

L-DOPA (DOPA) is generally considered to alleviate the symptoms of Parkinson’s disease by its conversion to dopamine. We have proposed that DOPA is itself a neurotransmitter. However, specific receptors for DOPA have not been identified. In this study, we demonstrated that GPR143, the gene product of ocular albinism 1 (OA1), mediated DOPA-induced depressor and bradycardic response in the nucleus tractus solitarii. OA1 was expressed not only in the central nervous system such as substantia nigra, striatum, olfactory bulb, hypothalamic median eminence and lower brain stem, but also in peripheral tissues including liver, kidney, lung and spleen. These findings further add to the evidence for a neurotransmitter role for DOPA.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Expression of ocular albinism 1 (OA1),3,4-dihydroxy-L-phenylalanine(DOPA) receptor, in both neuronal and non-neuronal organs.2015

    • Author(s)
      Fukuda N, Naito S, Masukawa D, Kaneda M, Miyamoto H, Abe T, Yamashita Y, Endo I, Nakamura F, Goshima Y
    • Journal Title

      Brain Research

      Volume: 1602 Pages: 62-74

    • DOI

      10.1016/j.brainres.2015.01.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system2014

    • Author(s)
      Masukawa D, Nakamura F, Koga M, Kamiya M, Chen S, Yamashita N, Arai N, Goshima Y
    • Journal Title

      Neuroscience Reseach

      Volume: 88 Pages: 49-57

    • DOI

      10.1016/j.neures.2014.07.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.2014

    • Author(s)
      Hiroshima Y, Miyamoto H, Nakamura F, Masukawa D, Yamamoto T, Muraoka H, Kamiya M, Yamashita N, Suzuki T, Matsuzaki S, Endo I, Goshima Y
    • Journal Title

      British Journal of Pharmacology

      Volume: 171 Issue: 2 Pages: 403-414

    • DOI

      10.1111/bph.12459

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 黒質線条体組織におけるドーパ受容体OA-1及びドパミン作動性神経マーカーとの局在性2015

    • Author(s)
      武山 奈央、増川 太輝、中村 史雄、五嶋 良郎
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 延髄弧束核領域において無作用濃度のドーパはグルタミン酸による高圧徐脈応答を増強する2015

    • Author(s)
      増川 太輝、中村 史雄、古賀 資和、五嶋 良郎
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢神経系におけるOA1の分布と機能2014

    • Author(s)
      増川 太輝、中村 史雄、古賀 資和、五嶋 良郎
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市立大学(神奈川県横浜市)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢神経系におけるL-DOPA受容体 OA-1 の発現分布2014

    • Author(s)
      増川 太輝、中村 史雄、五嶋 良郎
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] The gene product of ocular albinism 1 is the G protein-coupled receptor mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii2014

    • Author(s)
      Yoshio Goshima, Fumio Nakamura, Daiki Masukawa
    • Organizer
      World Congress of basic & clinical Pharmacology 2014
    • Place of Presentation
      ケープタウン(南アフリカ共和国)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] DOPA-induced depressor and bradycardiac response in the oa1-deficient mice2014

    • Author(s)
      Daiki Masukawa, Fumio Nakamura, Yoshio Goshima
    • Organizer
      World Congress of basic & clinical Pharmacology 2014
    • Place of Presentation
      ケープタウン(南アフリカ共和国)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢神経系におけるL-DOPA受容体OA-1の発現分布2014

    • Author(s)
      増川 太輝、中村 史雄、古賀 資和、五嶋 良郎
    • Organizer
      第130回日本薬理学会関東部会
    • Place of Presentation
      星薬科大学(東京都品川区)
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢神経系における新規L-DOPA受容体OA-1の発現分布2013

    • Author(s)
      神谷真梨奈, 山下直也, 佐々木幸生, 中村史雄, 五嶋良郎
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] L-DOPAはOA-1を介してCa^<2+>応答を惹起する2013

    • Author(s)
      兼田萌美, 中村史雄, 村岡秀紀, 五嶋良郎
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中枢神経系におけるドーパ受容体候補分子OA1の発現分布2012

    • Author(s)
      神谷真梨奈, 山下直也, 佐々木幸生, 中村史雄, 五嶋良郎
    • Organizer
      第127回薬理学会関東部会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] カルシウムイメージングによるドーパ受容体OA1の機能解析2012

    • Author(s)
      兼田萌美, 中村史雄, 村岡秀紀, 五嶋良郎
    • Organizer
      第127回薬理学会関東部会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Brainstem DOPAergic System2012

    • Author(s)
      五嶋良郎
    • Organizer
      The 10^<th> International Catecholamine Symposium
    • Place of Presentation
      Pacific Grove (米国)(招待講演)
    • Year and Date
      2012-09-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドーパ関連リガンドの同定ならびにニコチン・ドーパ応答の解析2012

    • Author(s)
      五嶋良郎, 竹居光太郎, 中村史雄, 小倉顕一, 山下直也
    • Organizer
      喫煙科学研究財団 平成23年度助成研究発表会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-07-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドーパ受容体候補分子の同定とニコチン作用における役割

    • Author(s)
      五嶋良郎、中村史雄、小倉顕一、山下直也、横山高玲
    • Organizer
      喫煙科学研究財団 2013年度助成研究発表会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 圧受容器反射における弧束核ドーパ受容体OA-1の役割

    • Author(s)
      増川太輝、廣島幸彦、宮本洋、中村史雄、五嶋良郎
    • Organizer
      第129回 日本薬理学会関東部会
    • Place of Presentation
      順天堂大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] OA1 mediates L-DOPA induced Ca2+ response in cultured hippocampal neurons.

    • Author(s)
      Fumio Nakamura, Moemi Kaneda, Yoshio Goshima
    • Organizer
      第87回 日本薬理学会年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Protein ocular albinism 1 is the G protein-coupled receptor and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii

    • Author(s)
      Daiki Masukawa, Hiroshi Miyamoto, Fumio Nakamura, Moemi Kaneda, Nobuhiko Fukuda, Saki Naito, Itaru Endo, Yoshio Goshima
    • Organizer
      第87回 日本薬理学会年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Distribution of L-DOPA receptor, ocular albinism 1(OA-1)-immunoreactivities in central and peripheral tissues

    • Author(s)
      Nobuhiko Fukuda, Saki Naito, Daiki Masukawa, Moemi Kaneda, Fumio Nakamura, Yoshio Goshima
    • Organizer
      第87回 日本薬理学会年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2013 Annual Research Report
  • [Book] Catecholamine Research in the 21st Century - Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 20122013

    • Author(s)
      Yoshio Goshima (Edited by Lee Eiden)
    • Total Pages
      328
    • Publisher
      Academic Press
    • Related Report
      2013 Annual Research Report
  • [Remarks] 横浜市立大学薬理学教室ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~pharmac/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 横浜市立大学分子薬理神経生物学教室 ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~pharmac/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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