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Molecular Species of phosphoinositides and their functions

Research Project

Project/Area Number 24390067
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionAkita University

Principal Investigator

SASAKI Junko  秋田大学, 医学(系)研究科(研究院), 准教授 (30333371)

Co-Investigator(Renkei-kenkyūsha) NAKANISHI Hiroki  秋田大学, 大学生体情報研究センター, 助教 (10466740)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords細胞内シグナル伝達 / イノシトールリン脂質
Outline of Final Research Achievements

We established the sensitive method for measuring phosphoinositides (PIs) by mass spectrometry, and found that various PIs molecular species were exist in cells. Through the analyses of the cells with overexpression or knockout of PIs metabolizing enzymes, it was suggested that each PIs species might have different cellular functions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 11 results,  Open Access: 3 results) Presentation (10 results) (of which Invited: 3 results) Book (4 results) Remarks (2 results)

  • [Journal Article] INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor.2015

    • Author(s)
      Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T.
    • Journal Title

      Cancer Discovery

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes.2015

    • Author(s)
      Chew CL, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, Pandolfi PP
    • Journal Title

      Cancer Discovery

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget.2015

    • Author(s)
      Ip LR, Poulogiannis G, Viciano FC, Sasaki J, Kofuji S, Spanswick VJ, Hochhauser D, Hartley JA, Sasaki T, Gewinner CA.
    • Journal Title

      Oncotarget

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Dachsous-Dependent Asymmetric Localization of Spiny-Legs Determines Planar Cell Polarity Orientation in Drosophila.2014

    • Author(s)
      Ayukawa T., Akiyama M., Mummery-Widmer JL., Stoeger T., Sasaki J., Knoblich JA., Senoo H., Sasaki T., Yamazaki M.
    • Journal Title

      Cell Rep.

      Volume: 8 Issue: 2 Pages: 610-621

    • DOI

      10.1016/j.celrep.2014.06.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphatidic acid-preferring phospholipase A1 regulates mitochondrial dynamics.2014

    • Author(s)
      Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 16 Pages: 11497-11511

    • DOI

      10.1074/jbc.m113.531921

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency2014

    • Author(s)
      Yuichi Abe, Masanori Honsho, Hiroki Nakanishi, Ryo Taguchi, Yukio Fujiki
    • Journal Title

      BBA - Molecular and Cell Biology of Lipids

      Volume: 1841 Issue: 4 Pages: 610-619

    • DOI

      10.1016/j.bbalip.2014.01.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リピドミクスの分析技術と将来展望2014

    • Author(s)
      中西広樹
    • Journal Title

      オレオサイエンス誌

      Volume: 8 Pages: 321-327

    • NAID

      130005308258

    • Related Report
      2014 Annual Research Report
  • [Journal Article] A Ca2+-dependent signaling circuit regulates influenza A virus internalization and infection2013

    • Author(s)
      Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y
    • Journal Title

      Nature Co㎜unnications

      Volume: 4 Issue: 1 Pages: 2-763

    • DOI

      10.1038/ncomms3763

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation.2013

    • Author(s)
      森下英晃、江口賢史、木村洋貴、佐々木純子、酒巻有里子、Robinson ML、佐々木雄彦、水島昇
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 16 Pages: 11436-47

    • DOI

      10.1074/jbc.m112.437103

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.2013

    • Author(s)
      Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
    • Journal Title

      Lipids Health Dis

      Volume: 12 Issue: 1 Pages: 68-68

    • DOI

      10.1186/1476-511x-12-68

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators2013

    • Author(s)
      Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
    • Journal Title

      J Exp Med.

      Volume: 210 Issue: 6 Pages: 1217

    • DOI

      10.1084/jem.20121887

    • URL

      https://localhost/en/publications/f155de96-9f1f-4e30-aa42-9276a14b59bd

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular species of phospholipids with very long chain fatty acids in skin fibroblasts of Zellweger syndrome2013

    • Author(s)
      Hama K, Nagai T, Nishizawa C, Ikeda K, Morita M, Satoh N, Nakanishi H, Imanaka T, Shimozawa N, Taguchi R, Inoue K, Yokoyama K.
    • Journal Title

      Lipids

      Volume: 48 Issue: 12 Pages: 1253

    • DOI

      10.1007/s11745-013-3848-5

    • URL

      https://pure.teikyo.jp/en/publications/f8e07bda-4383-4ed1-a03a-a9ac4ce59e47

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine2012

    • Author(s)
      Takasuga , Wada et al.
    • Journal Title

      PNAS 110

      Volume: 1726-1731 Issue: 5 Pages: 1726-31

    • DOI

      10.1073/pnas.1213212110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice2012

    • Author(s)
      Lee, HC et al.
    • Journal Title

      Mol. Biol. Cell

      Volume: 23 Issue: 24 Pages: 4689

    • DOI

      10.1091/mbc.e12-09-0673

    • URL

      https://localhost/en/publications/cb9820d8-1e85-4b31-9050-305a9f812c8a

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.2012

    • Author(s)
      Neely GG
    • Journal Title

      PLoS Genet.

      Volume: 8 Issue: 12 Pages: e1003071-e1003071

    • DOI

      10.1371/journal.pgen.1003071

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The class III PI3K and phosphatidylinositol 3-phosphate ensure structural and functional integrity of cardiomyocytes2015

    • Author(s)
      Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Takehiko Sasaki
    • Organizer
      the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      兵庫
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] The novel mechanism of tumor suppression by INPP4B2015

    • Author(s)
      Junko Sasaki, Satoshi Kofuji, Takahiro Kimura, Shunsuke Takasuga, Hiroki Nakanishi, Takehiko Sasaki
    • Organizer
      2nd International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
    • Place of Presentation
      東京
    • Year and Date
      2015-01-23 – 2015-01-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Macrophage activation by phosphoinositides.2013

    • Author(s)
      Junko Sasaki
    • Organizer
      Frontiers in Immunology & Inflammation: From Molecules to Disease
    • Place of Presentation
      東京
    • Year and Date
      2013-02-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] マクロファージの活性化と慢性炎症2012

    • Author(s)
      佐々木純子
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2012-07-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量分析法によるホスホイノシタイドの解析

    • Author(s)
      佐々木 純子
    • Organizer
      「修飾シグナル病」第3回公開シンポジウム シグナル伝達解析技術と数理モデルの最先端
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] イノシトールリン脂質によるマクロファージの活性化と寿命制御

    • Author(s)
      佐々木純子、中西広樹、高須賀俊輔、佐々木雄彦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Dual specificity phosphatases acting on acidic phospholipids

    • Author(s)
      佐々木 雄彦, 高須賀 俊輔, 佐々木 純子, 鈴木 聡
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] ホスファチジルグリセロールリン酸(PGP)ホスファターゼの生理機能

    • Author(s)
      高須賀俊輔、浅沼研、木村洋貴、高須賀緑、中西広樹、佐々木純子、 山崎正和、妹尾春樹、佐々木雄彦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] イノシトールリン脂質によるマクロファージの活性化

    • Author(s)
      佐々木 純子
    • Organizer
      第1回Academy of Aging and Cardiovascular-Diabetes Research
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 酸化関連脂質代謝物の高感度分析法の開発と応用

    • Author(s)
      中西広樹
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      宮城
    • Related Report
      2013 Annual Research Report
  • [Book] 医学のあゆみ2014

    • Author(s)
      佐々木雄彦、中西広樹
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Annual Research Report
  • [Book] 別冊BIO Clinica 骨髄―末梢血による炎症の制御と修飾2013

    • Author(s)
      佐々木純子、佐々木雄彦
    • Publisher
      北隆館
    • Related Report
      2013 Annual Research Report
  • [Book] 実験医学別冊2013

    • Author(s)
      中西広樹
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 遺伝子医学MOOK2013

    • Author(s)
      中西広樹
    • Publisher
      医療総合出版
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~bisei/

    • Related Report
      2014 Annual Research Report
  • [Remarks] http://www.med.akita-u.ac.jp/~bisei/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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