Quality control of insulin granule exocytosis
| Project/Area Number |
24390068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
IZUMI Tetsuro 群馬大学, 生体調節研究所, 教授 (00212952)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | インスリン / 分泌顆粒 / 開口放出 / 細胞内膜輸送 / 糖尿病 |
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| Outline of Final Research Achievements |
We have analyzed the function of multiple Rab27 effector proteins expressed in pancreatic beta cells. As a result, we have identified novel roles of three Rab27 effector proteins in insulin granule exocytosis. First, Noc2 has a role in connecting maturation and exocytosis steps by interacting with both Rab2a and Rab27a. Second, exophilin8 is involved in the transport of granules to cell periphery by binding a novel protein. Third, granuphilin is an exclusive component of the functional and fusion-inhibitory docking machinery of secretory granules. Thus, three kinds of Rab27 effector proteins function in completely different exocytic processes in pancreatic beta cells.
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Report
(5 results)
Research Products
(31 results)
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[Journal Article] PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a2016
Author(s)
Yamaoka M, Ando T, Terabayashi T, Okamoto M, Takei M, Nishioka T, Kaibuchi K, Matsunaga K, Ishizaki R, Izumi T, Niki I, Ishizaki T, Kimura T
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Journal Title
Journal of Cell Science
Volume: 129
Issue: 3
Pages: 637-649
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.2013
Author(s)
Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H
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Journal Title
Endocrinology
Volume: 154
Issue: 10
Pages: 3577-88
DOI
Related Report
Peer Reviewed / Open Access
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