Contribution of megakaryocytes and platelets to pathogenesis of chronic inflammation

• Project/Area Number: 24390075
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: MOTOHASHI Hozumi 東北大学, 加齢医学研究所, 教授 (00282351)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: 転写因子 / 血小板 / 巨核球 / 炎症 / ストレス / 遺伝子 / 転写制御

Outline of Final Research Achievements

A goal of this research was to clarify a role of platelets and megakaryocytes during the pathogenesis of chronic inflammation through examining the function of NF-E2 p45 in proliferation and differentiation of megakaryocytes and platelet production. We clarified a profile of NF-E2 p45 target genes in megakaryocytes and found that NF-E2 p45 not only promotes platelet production but also confers sufficient reactivity on platelets. It is plausible that these NF-E2 target genes are upregulated during inflammation and contribute to the pathogenesis.

Research Products

• [Journal Article] Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. (2015)
  • Author(s): Kanamori M*, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H*, and Tominaga T.
  • Journal Title: Neuro-Oncology Volume: 17 Issue: 4 Pages: 555-565
  • DOI: 10.1093/neuonc/nou282
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism. (2015)
  • Author(s): de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA.
  • Journal Title: Cell Metab Volume: 21 Issue: 2 Pages: 298-310
  • DOI: 10.1016/j.cmet.2015.01.007
  • Peer Reviewed
• [Journal Article] Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice. (2014)
  • Author(s): Shirasaki K, Taguchi K, Unno M, Motohashi H, and Yamamoto M
  • Journal Title: Hepatology Volume: 59 Issue: 6 Pages: 2371-2382
  • DOI: 10.1002/hep.27020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. (2014)
  • Author(s): Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 19 Issue: 8 Pages: 650-665
  • DOI: 10.1111/gtc.12165
  • Peer Reviewed / Open Access
• [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. (2014)
  • Author(s): Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: (印刷中) Issue: 21 Pages: 7606-7611
  • DOI: 10.1073/pnas.1321232111
  • Peer Reviewed / Open Access
• [Journal Article] Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by keratin 14 promoter (2014)
  • Author(s): Murakami S., Yamamoto M. and Motohashi H
  • Journal Title: Toxicological Sciences Volume: 138 Issue: 1 Pages: 47-58
  • DOI: 10.1093/toxsci/kft273
  • Peer Reviewed
• [Journal Article] Keap 1-Nrf2 system regulates cell fate determination of hematopoietic stem cells (2014)
  • Author(s): Murakami S., Shimizu R., Romeo P. H., Yamamoto M. Motohashi H.
  • Journal Title: Genes to Cells Volume: 19 Issue: 3 Pages: 239-253
  • DOI: 10.1111/gtc.12126
  • Peer Reviewed
• [Journal Article] NRF2 immunolocalization in human breat cancer patients as a prognostic factor. (2014)
  • Author(s): Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, and Suzuki T.
  • Journal Title: Endocri Relat Cancer Volume: 21 Issue: 2 Pages: 241-252
  • DOI: 10.1530/erc-13-0234
  • Peer Reviewed
• [Journal Article] Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. (2014)
  • Author(s): Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, and Yamamoto M.
  • Journal Title: Mol. Cell. Biol. Volume: 34 Issue: 5 Pages: 900-913
  • DOI: 10.1128/mcb.01384-13
  • Peer Reviewed / Open Access
• [Journal Article] Disruption of the hbsll-myb locus causes hereditary persistence of fetal hemoglobin in a mouse model. (2013)
  • Author(s): Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe 0, Engel JD, Yamamoto M.
  • Journal Title: Molecular and Cellular Biology Volume: 33 Issue: 8 Pages: 1687-1695
  • DOI: 10.1128/mcb.01617-12
  • Peer Reviewed
• [Journal Article] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels. (2013)
  • Author(s): Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 12 Pages: 2402-2412
  • DOI: 10.1128/mcb.00065-13
  • Peer Reviewed
• [Journal Article] NF-E2 p45 is important for establishing normal function of platelets. (2013)
  • Author(s): Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M*, and Motohashi H* (* corresponding authors)
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 14 Pages: 2659-2670
  • DOI: 10.1128/mcb.01274-12
  • Peer Reviewed
• [Journal Article] Transforming growth factor-&βinduces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. (2013)
  • Author(s): Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Ogami T, Koinuma D, Kato M.
  • Journal Title: J Biol Chem Volume: 288 Issue: 28 Pages: 20658-20667
  • DOI: 10.1074/jbc.m113.450478
  • NAID: 120007136878
  • Peer Reviewed
• [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013)
  • Author(s): Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
  • Journal Title: Mol Cell Volume: 51 Issue: 5 Pages: 618-631
  • DOI: 10.1016/j.molcel.2013.08.003
  • Peer Reviewed / Open Access
• [Journal Article] Toward clinical application of the Keap1-Nrf2 pathway. (2013)
  • Author(s): Suzuki T, Motohashi H, and Yamamoto M*.
  • Journal Title: Trends Pharmacol. Sci. Volume: 34 Issue: 6 Pages: 340-346
  • DOI: 10.1016/j.tips.2013.04.005
  • Peer Reviewed
• [Journal Article] がん細胞におけるKeap1-Nrf2制御系の機能と役割 (2013)
  • Author(s): 村上昌平、本橋ほづみ
  • Journal Title: 医学のあゆみ Volume: 247 Pages: 811-818
• [Journal Article] 環境応答破綻がもたらす炎症の慢性化機構 (2013)
  • Author(s): 森口 尚，本橋ほづみ, 山本雅之
  • Journal Title: Bio Clinica Volume: 28(12) Pages: 12-23
• [Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. (2012)
  • Author(s): Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M*, and Motohashi H*.
  • Journal Title: Cancer Cell Volume: 22 Pages: 66-79
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. (2012)
  • Author(s): Nishida M., et al
  • Journal Title: Nature Chen. Biol. Volume: 8 Issue: 8 Pages: 714-724
  • DOI: 10.1038/nchembio.1018
  • Peer Reviewed
• [Journal Article] Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. (2012)
  • Author(s): Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW and Yamamoto M.
  • Journal Title: Free Rad Biol Med Volume: 53 Issue: 4 Pages: 817-827
  • DOI: 10.1016/j.freeradbiomed.2012.06.023
  • Peer Reviewed
• [Journal Article] Keap1 degradation by autophagy for the maintenance of redox homeostasis (2012)
  • Author(s): Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Issue: 34 Pages: 13561-13566
  • DOI: 10.1073/pnas.1121572109
  • Peer Reviewed
• [Journal Article] がん細胞におけるKeap1-Nrf2システムの破綻 (2012)
  • Author(s): 光石陽一郎、本橋ほづみ
  • Journal Title: 実験医学 Volume: 30 Pages: 2437-2442
• [Journal Article] 代謝リプログラミングにおける酸化ストレス応答機構の役割 (2012)
  • Author(s): 田口恵子、本橋ほづみ
  • Journal Title: 実験医学 Volume: 30 Pages: 2814-2821
• [Journal Article] The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism. (2012)
  • Author(s): Mitsuishi Y, Motohashi H*, and Yamamoto M*
  • Journal Title: Front. Oncol. Volume: 2 Pages: 200-200
  • DOI: 10.3389/fonc.2012.00200
  • Peer Reviewed
• [Journal Article] 巨核球分化・血小板産生制御に貢献する転写調節機構. (2012)
  • Author(s): 藤田理恵, 本橋ほづみ, 山本雅之
  • Journal Title: 日本血栓止血学会誌 Volume: 23 Pages: 539-543
  • NAID: 130003367323
• [Presentation] IDH1遺伝子変異によるNRF2機能抑制と代謝リプログラミング (2015)
  • Author(s): 本橋ほづみ
  • Organizer: 国際高等研究所研究プロジェクト クロマチンデコーディング研究会
  • Place of Presentation: 京都
  • Year and Date: 2015-03-21
  • Invited
• [Presentation] ホルムアルデヒド解毒代謝酵素Alcohol Dehyderogenase 3 (ADH3) (2015)
  • Author(s): 井田智章、Md. Morshedul Alam、松永哲郎、藤井重元、居原秀、本橋ほづみ、赤池孝章
  • Organizer: 第14回分子予防環境医学研究会大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] Functional nexus between Keap1-Nrf2 system and cellular metabolism (2015)
  • Author(s): 本橋ほづみ
  • Organizer: Joint International Symposium on TGF- Family and Cancer: Signaling Network in Tumor Microenvironment
  • Place of Presentation: つくば
  • Year and Date: 2015-01-13
  • Invited
• [Presentation] オートファジー障害に伴う糖、アミノ酸代謝再編成 (2014)
  • Author(s): 斉藤哲也、曽友深、和栗聡、藤村務、上野隆、田口恵子、本橋ほづみ、山本雅之、田中啓二、曽我朋義、小松雅明
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Adh3とKeap1-Nrf2制御系の協調作用による酸化ストレス防御機構 (2014)
  • Author(s): 本橋ほづみ
  • Organizer: 基盤S公開シンポジウム「親電子物質のレドックス制御」
  • Place of Presentation: つくば
  • Year and Date: 2014-10-27
  • Invited
• [Presentation] ヒトIL-6遺伝子BAC（大腸菌人工染色体）レポーターマウスを用いたin vivoイメージングによる炎症状態モニタリングシステムの開発とその利用 (2014)
  • Author(s): 林真貴子、高井淳、于磊、本橋ほづみ、森口尚、山本雅之
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ペルオキシレドキシンによるピルビン酸キナーゼの化成制御は代謝変化および酸化ストレス応答に寄与する (2014)
  • Author(s): 色川隼人、松山由香、本橋ほづみ、岩井健太、久下周佐
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 活性システインパーサフファイドとS-ポリチオレーションが酸化ストレスを制御する (2014)
  • Author(s): 井田智章、澤智裕、居原秀、土屋幸弘、渡邊泰男、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、山本雅之、Ming Xian、Jon Fukuto、赤池孝章
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 生体防御における転写因子Nrf2とグルタチオン依存性ホルムアルデヒド脱水素酵素Adh3による協調作用 (2014)
  • Author(s): 後藤まき、北村大志、井田智章、澤智裕、赤池孝章、長谷場健、秋元敏雄、山本（高野）照子、山本雅之、本橋ほづみ
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Nrf2の制御破綻が引き起こす肝病態 (2014)
  • Author(s): 田口恵子、本橋ほづみ、山本雅之
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15
• [Presentation] Megakaryocyte differentiation and platelet production regulated by CNC transcription factor family (2014)
  • Author(s): 本橋ほづみ
  • Organizer: 第87回日本生化学会大会 シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15
  • Invited
• [Presentation] Keap1-Nrf2 system for redox regulation and metabolic reprogramming in cancers (2014)
  • Author(s): 本橋ほづみ
  • Organizer: 第73回日本癌学会学術総会 コアシンポジウム”Cancer cell metabolism and cellular senescence”
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] Nrf2の制御破綻が引き起こす肝病態 (2014)
  • Author(s): 田口恵子、本橋ほづみ、山本雅之
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Keap1-Nrf2制御系によるストレス応答と細胞増殖制御 (2014)
  • Author(s): 本橋ほづみ
  • Organizer: 第157回日本獣医学会学術集会 日本比較薬理学・毒性学会シンポジウム「細胞保護機構の多面性」
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-10
  • Invited
• [Presentation] IDH1遺伝子変異がもたらすNRF2機能への影響の解析 (2014)
  • Author(s): 北村大志、百々美奈、比嘉剛志、金森政之、本橋ほづみ
  • Organizer: 新学術領域研究「転写代謝システム」領域班会議
  • Place of Presentation: 秋保
  • Year and Date: 2014-07-11 – 2014-07-13
• [Presentation] 転写因子Nrf2とグルタチオン依存性ホルムアルデヒド脱水素酵素Adh3による協調的生体防御機構 (2014)
  • Author(s): 後藤まき、北村大志、澤智裕、赤池孝章、長谷場健、秋元敏雄、山本照子、山本雅之、本橋ほづみ
  • Organizer: 新学術領域研究「転写代謝システム」領域班会議
  • Place of Presentation: 秋保
  • Year and Date: 2014-07-11 – 2014-07-13
• [Presentation] 造血幹細胞におけるKeap1-Nrf2制御系の役割の解明 (2014)
  • Author(s): 村上昌平、山本雅之、本橋ほづみ
  • Organizer: 新学術領域研究「転写代謝システム」領域班会議
  • Place of Presentation: 秋保
  • Year and Date: 2014-07-11 – 2014-07-13
• [Presentation] ヒトIL-6 遺伝子BAC（大腸菌人工染色体）レポーターマウスを用いたin vivoイメージングによる炎症状態モニターリングシステムの開発 (2014)
  • Author(s): 林真貴子、高井淳、Yu Lei、本橋ほづみ、森口尚、山本雅之
  • Organizer: 新学術領域研究「転写代謝システム」領域班会議
  • Place of Presentation: 秋保
  • Year and Date: 2014-07-11 – 2014-07-13
• [Presentation] 新たな治療標的としてのNrf2によるストレス応答と代謝制御 (2014)
  • Author(s): 本橋ほづみ
  • Organizer: 第19回日本がん分子標的治療学会 シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-26
  • Invited
• [Presentation] Contribution of a transcription factor NF-E2 to megakaryocyte differentiation and platelet production (2014)
  • Author(s): 本橋ほづみ
  • Organizer: 第36回日本血栓止血学会 SPCシンポジウム2014
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-29
  • Invited
• [Presentation] Transcriptional regulation driving megakaryocyte maturation and platelet production (2014)
  • Author(s): 本橋ほづみ
  • Organizer: IAS Research Conference 2014 and IIAS Lecture 2014 “Chromatin Decoding”
  • Place of Presentation: 京都
  • Year and Date: 2014-05-12 – 2014-05-15
  • Invited
• [Presentation] 肝毒性物質に応答した肝保護にはたらくNrf2の役割 (2014)
  • Author(s): 田口恵子、本橋ほづみ、山本雅之
  • Organizer: 日本生化学会東北支部例会
  • Place of Presentation: 秋田
  • Year and Date: 2014-05-10
• [Presentation] Keap1-Nrf2制御系の造血幹細胞における役割の解明 (2014)
  • Author(s): 村上昌平、山本雅之、本橋ほづみ
  • Organizer: 日本生化学会東北支部例会
  • Place of Presentation: 秋田
  • Year and Date: 2014-05-10
• [Presentation] ADH3とNRF2によるGSH依存的な協調作用 (2014)
  • Author(s): 後藤まき、長谷場健、山本照子、山本雅之、本橋ほづみ
  • Organizer: 日本生化学会東北支部例会
  • Place of Presentation: 秋田
  • Year and Date: 2014-05-10
• [Presentation] Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice. (2014)
  • Author(s): Keiichi Shirasaki, Keiko Taguchi, Michiaki Unno, Hozumi Motohashi, Masayuki Yamamoto.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
• [Presentation] Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. (2014)
  • Author(s): Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
• [Presentation] Nrf2 and Adh3 cooperates in cytoprotection from oxidative stress. (2014)
  • Author(s): Maki Goto, Hiroshi Kitamura, Tomohiro Sawa, Takaaki Akaike, Takeshi Haseba, Toshio Akimoto, Teruko Yamamoto, Masayuki Yamamoto, Hozumi Motohashi.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
• [Presentation] Functional analysis of Keap1-Nrf2 system in hematopoietic stem cells. (2014)
  • Author(s): Shohei Murakami, Masayuki Yamamoto, Hozumi Motohashi.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
• [Presentation] Real-time in vivo monitoring of inflammatory status exploiting human interleukin-6 BAC luciferase transgenic mice. (2014)
  • Author(s): Jun Takai, Makiko Hayashi, Hozumi Motohashi, Takashi Moriguchi, Masayuki Yamamoto.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
• [Presentation] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels. (2014)
  • Author(s): Takafumi Suzuki, Tatsuhiro Shibata, Kai Takaya, Kouya Shiraishi, Takashi Kohno, Hideo Kunitoh, Koji Tsuta, Koh Furuta,Koiichi Goto, Fumie Hosoda, Hiromi Sakamoto, Hozumi Motohashi, Masayuki Yamamoto.
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
• [Presentation] Crosstalk between redox regulation and cell proliferation. (2014)
  • Author(s): Hozumi Motohashi
  • Organizer: International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discovery in Academics.
  • Place of Presentation: 金沢
  • Invited
• [Presentation] Future of the Keap1-Nrf2 pathway. (2014)
  • Author(s): Hozumi Motohashi
  • Organizer: The Environmental Response IV
  • Place of Presentation: 仙台
  • Invited
• [Presentation] がん細胞におけるKeap1-Nrf2制御系の役割 (2013)
  • Author(s): 本橋ほづみ
  • Organizer: がんと代謝 メタボロミクスセミナー
  • Place of Presentation: 国立がん研究センター研究所 東京(招待講演)
  • Year and Date: 2013-03-13
• [Presentation] Nrf2 enhances a hepatotoxin-induced hepatic cell expansion. (2013)
  • Author(s): Taguchi K, Motohashi H, Yamamoto M.
  • Organizer: The XIII International Congress of Toxicology (ICT2013)
  • Place of Presentation: Seoul, Korea
• [Presentation] Two distinct mechanisms for degradation of a transcription factor Nrf2. (2013)
  • Author(s): Taguchi K, Motohashi H, Yamamoto M.
  • Organizer: The 35th NAITO Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
  • Place of Presentation: 札幌
• [Presentation] The atomospheric scanning electron microscope (ASEM) observes the critical moment of platelet generation from megakaryocytes in solution. (2013)
  • Author(s): Sato C, Nishiyama H, Maruyama Y, Ebihara T, Suga M, Yamamoto M and Motohashi H.
  • Organizer: Microscopy & Microanalysis 2013
  • Place of Presentation: Indianapolis, Indiana, USA
• [Presentation] NF-E2 p45 is important for establishing normal function of platelets. (2013)
  • Author(s): Rie Fujita, Hiroyuki Aburatani, Emery H Bresnick, Masayuki Yamamoto, Hozumi Motohashi.
  • Organizer: 42nd Annual Scientific Meeting of ISEH.
  • Place of Presentation: Vienna, Austria
• [Presentation] 肝毒性物質による肝肥大における転写因子Nrf2の役割 (2013)
  • Author(s): 田口恵子、本橋ほづみ、伊藤暢、田中稔、宮島篤、山本雅之
  • Organizer: フォーラム2013：衛生薬学・環境トキシコロジー
  • Place of Presentation: 博多
• [Presentation] 門脈枝結紮による代償的肝肥大におけるNrf2の役割 (2013)
  • Author(s): 田口恵子、白崎圭一、本橋ほづみ、山本雅之
  • Organizer: 新学術研究「修飾シグナル病」若手ワークショップ
  • Place of Presentation: 伊香保
• [Presentation] Functional expansion of Nrf2 under the sustained activation of proliferative signals. (2013)
  • Author(s): Hozumi Motohashi, Tsuyoshi Higa, Keiko Taguchi, Yoichiro Mitsuishi, Masayuki Yamamoto.
  • Organizer: Keystone Symposium on Nutrition, Eppigenetics and Human Diseases.
  • Place of Presentation: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, New Mexico, USA.
• [Presentation] がん細胞におけるストレス応答と代謝リプログラミング (2013)
  • Author(s): 本橋ほづみ
  • Organizer: がんと代謝シンポジウム
  • Place of Presentation: 慶應義塾大学医学部信濃町キャンパス 東京(招待講演)
• [Presentation] Keap1-Nrf2 system in metabolic reprogramming of cancer cells. (2012)
  • Author(s): Hozumi Motohashi
  • Organizer: 新学術領域研究「活性酸素シグナル」公開国際シンポジウム
  • Place of Presentation: 九州大学 福岡(招待講演)
  • Year and Date: 2012-12-17
• [Presentation] がん細胞における酸化ストレス応答と代謝リプログラミング (2012)
  • Author(s): 本橋ほづみ
  • Organizer: 日本医科大学医学会特別講演会
  • Place of Presentation: 日本医科大学 東京(招待講演)
  • Year and Date: 2012-11-28
• [Presentation] がん細胞における酸化ストレス応答と代謝制御 (2012)
  • Author(s): 本橋ほづみ
  • Organizer: 第7回メタボロームシンポジウム ランチョンセミナー
  • Place of Presentation: 慶應義塾大学先端生命科学研究所 鶴岡(招待講演)
  • Year and Date: 2012-10-12
• [Presentation] がん細胞における酸化ストレス応答と代謝リプログラミング (2012)
  • Author(s): 本橋ほづみ
  • Organizer: 京都大学放生研セミナー
  • Place of Presentation: 京都大学放射線生物研究センター 京都(招待講演)
  • Year and Date: 2012-09-14
• [Presentation] Keap1-Nrf2制御系による酸化ストレス応答機構 (2012)
  • Author(s): 本橋ほづみ
  • Organizer: 第55回放射線影響学会
  • Place of Presentation: 仙台 東北大学川内北キャンパス
• [Presentation] 造血幹細胞・前駆細胞におけるKeap1-Nrf2制御系の役割の解明 (2012)
  • Author(s): 村上昌平、本橋ほづみ、山本雅之
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] 転写因子NF-E2 p45による血小板機能調節遺伝子の転写活性化 (2012)
  • Author(s): 藤田理恵、辻本昌理子、藤井聡、皿井明倫、油谷浩幸、本橋ほづみ、山本雅之
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] 肝臓における2つのNrf2活性制御機構と胆管形成 (2012)
  • Author(s): 田口恵子、本橋ほづみ、山本雅之
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] がん細胞における酸化ストレス応答機構の役割と代謝リプログラミングへの貢献 (2012)
  • Author(s): 光石陽一郎、田口恵子、山本雅之、本橋ほづみ
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] Cross-re gulation of redox homeostasis and anabolic metabolism by the Keap1-Nrf2 pathway. (2012)
  • Author(s): Hozumi Motohashi
  • Organizer: The 33rd NAITO Conference on "Oxygen Biology:Hypoxia, Oxidative Stress and Diseases."
  • Place of Presentation: Chateraise Gateaux Kingdom SAPPORO, Sapporo(招待講演)
• [Presentation] がん細胞におけるKeap1-Nrf2制御系の役割 (2012)
  • Author(s): 本橋ほづみ
  • Organizer: 第29回臨床フリーラジカル会議
  • Place of Presentation: 里山の休日 京都・烟河(招待講演)
• [Presentation] 造血幹細胞・前駆細胞におけるKeap1-Nrf2制御系の役割の解明
  • Author(s): 村上昌平、本橋ほづみ、山本雅之
  • Organizer: 日本生化学会東北支部第79会例会
  • Place of Presentation: 仙台
• [Presentation] 生体防御におけるNrf2制御系とAdh3の協調作用の重要性
  • Author(s): 後藤まき、長谷場健、鈴木教郎、山本照子、山本雅之、本橋ほづみ
  • Organizer: 日本生化学会東北支部第79会例会
  • Place of Presentation: 仙台
• [Presentation] Contribution of Nrf2 pathway to metabolic reprogramming during cell proliferation.
  • Author(s): Hozumi Motohashi, Keiichi Shirasaki, Yoichiro Mitsuishi, Keiko Taguchi, Masayuki Yamamoto.
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] 門脈枝結紮による代償性肝肥大におけるNrf2の役割
  • Author(s): 白崎圭一、田口恵子、本橋ほづみ、海野倫明、山本雅之
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.
  • Author(s): 鈴木隆史、柴田龍弘、高屋快、本橋ほづみ、山本雅之
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] 肝毒性物質による肝肥大におけるNrf2の貢献
  • Author(s): 田口恵子、本橋ほづみ、伊藤暢、田中稔、宮島篤、山本雅之
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] Nrf2制御系とAdh3の協調作用による生体防御機構の解析
  • Author(s): 後藤まき、長谷場健、鈴木教郎、山本雅之、山本照子、本橋ほづみ
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] Contribution of Keap1-Nrf2 pathway to metabolic reprogramming during cell proliferation.
  • Author(s): Hozumi Motohashi, Keiichi Shirasaki, Yoichiro Mitsuishi, Keiko Taguchi, Masayuki Yamamoto.
  • Organizer: International Symposium on Transcription and Metabolism
  • Place of Presentation: 淡路島
• [Presentation] Contribution of Keap1-Nrf2 pathway to metabolic reprogramming and cell proliferation.
  • Author(s): Hozumi Motohashi, Keiichi Shirasaki, Yoichiro Mitsuishi, Keiko Taguchi, Masayuki Yamamoto.
  • Organizer: France-Japan Cancer, International Scientific Coordination Network
  • Place of Presentation: Toulouse, France
• [Presentation] 細胞増殖におけるKeap1-Nrf2酸化ストレス応答機構の役割
  • Author(s): 本橋ほづみ、白崎圭一、光石陽一郎、田口恵子、山本雅之
  • Organizer: 第３６回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] がん細胞における酸化ストレス応答と代謝リプログラミング
  • Author(s): 本橋ほづみ
  • Organizer: 武田薬品 癌創薬ユニットセミナー
  • Place of Presentation: 藤沢
  • Invited
• [Presentation] Keap1-Nrf2ストレス応答機構によるがん細胞の代謝リプログラミング
  • Author(s): 本橋ほづみ
  • Organizer: 東北大学加齢医学研究所 集談会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] Keap1-Nrf2制御系によるストレス応答と代謝リプログラミング
  • Author(s): 本橋ほづみ
  • Organizer: 名古屋大学大学院基盤医学特論 特徴あるプログラム Cancer Science Course
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 巨核球におけるレッドックス制御と血小板機能
  • Author(s): 本橋ほづみ
  • Organizer: 第24回日本生体防御学会学術総会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] Keap1-Nrf2ストレス応答機構による代謝リプログラミングと細胞増殖
  • Author(s): 本橋ほづみ
  • Organizer: TARAセミナー
  • Place of Presentation: つくば
  • Invited
• [Presentation] Keap1-Nrf2制御系によるストレス応答と代謝リプログラミング
  • Author(s): 本橋ほづみ
  • Organizer: 第６回Symphony
  • Place of Presentation: 東京
  • Invited
• [Presentation] 細胞増殖におけるKeap1-Nrf2酸化ストレス応答機構の役割
  • Author(s): 本橋ほづみ
  • Organizer: 第１回がんと代謝研究会
  • Place of Presentation: 鶴岡
  • Invited
• [Presentation] Keap1-Nrf2制御系によるストレス応答と代謝リプログラミング
  • Author(s): 本橋ほづみ
  • Organizer: 第383回東北医学会例会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] Keap1-Nrf2制御系によるストレス応答と代謝リプログラミング
  • Author(s): 本橋ほづみ
  • Organizer: 東北薬科大学セミナー
  • Place of Presentation: 仙台
  • Invited
• [Remarks] 東北大学加齢医学研究所 加齢制御研究部門 遺伝子発現制御分野
  • URL: http://www2.idac.tohoku.ac.jp/dep/ger/