Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles
| Project/Area Number |
24390082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kumamoto University (2012, 2014)
Tohoku University (2013) |
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Principal Investigator |
SAWA Tomohiro 熊本大学, 生命科学研究部, 教授 (30284756)
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| Co-Investigator(Kenkyū-buntansha) |
AKAIKE Takaaki 東北大学, 大学院医学系研究科, 教授 (20231798)
YOSHITAKE Jun 国立長寿医療研究センター, 研究院 (70414349)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMAGAI Yoshito 筑波大学, 大学院人間総合科学研究科, 教授 (00250100)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 活性酸素 / 酸化ストレス / シグナル伝達 / レドックス / 親電子 |
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| Outline of Final Research Achievements |
This study identified the endogenous formation of cysteine persulfide species that brings additional sulfur atom to cysteine thiol. It is noteworthy that cysteine persulfide species are capable of metabolizing reactive oxygen species and their second messenger molecules such as 8-nitro-cGMP. Further study is warranted to clarify regulatory mechanisms of cycteine persulfide species formation as well as their biological functions.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014
Author(s)
Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: (印刷中)
Issue: 21
Pages: 7606-7611
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The redox chemistry and chemical biology of H2S, hydropersulfides and derivaed species: implications to their possible biological activity and utility.2014
Author(s)
Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
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Journal Title
Free Radic. Biol. Med.
Volume: 77
Pages: 82-94
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014
Author(s)
Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
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Journal Title
Cell Metab.
Volume: 9
Issue: 4
Pages: 712-721
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013
Author(s)
Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
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Journal Title
Mol. Cell
Volume: 52
Issue: 6
Pages: 794-804
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
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Journal Title
FASEB J
Volume: 27
Issue: 1
Pages: 391-398
DOI
Related Report
Peer Reviewed
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