Regulation of gastric cancer development by mucin-type glycans
Project/Area Number |
24390086
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Shinshu University |
Principal Investigator |
NAKAYAMA Jun 信州大学, 学術研究院医学系, 教授 (10221459)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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Keywords | 胃癌 / 幽門腺型腺腫 / 慢性萎縮性胃炎 / バレット食道 / 遺伝子改変マウス / 糖鎖 / 腺粘液 / 病理診断 / 胃幽門腺型腺腫 / ノックアウトマウス / 慢性炎症 / 糖鎖遺伝子 |
Outline of Final Research Achievements |
Gastric gland mucins contain terminal α1,4-linked N-acetylglucosamine (αGlcNAc). This glycan prevents gastric cancer development by exhibiting antimicrobial activity against H. pylori as well as suppressing chronic inflammation. In this study, we analyzed expression of αGlcNAc and its pathological significance on human gastric diseases including gastric adenocarcinoma, pyloric gland adenoma, and chronic atrophic gastritis as well as Barrett's esophagus. Our results indicate that reduction or loss of αGlcNAc are associated with malignant potential of gastric differentiated-type adenocarcinoma and pyloric gland adenoma. We also showed that reduced αGlcNAc expression in chronic atrophic gastritis and Barrett's esophagus was a possible risk factor to develop gastric differentiated-type adenocarcinoma and Barrett's adenocarcinoma, respectively. In parallel, we generated new genetically engineered mice useful to study the regulatory roles of αGlcNAc in tumorigenesis of gastric cancer.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Reduced expression of αGlcNAc in Barrett’s esophagus adjacent to Barrett’s adenocarcinoma - Possible biomarker to predict the malignant potential of Barrett’s esophagus -2014
Author(s)
waya Y, Hasebe O, Koide N, Kitahara K, Suga T, Shinji A, Muraki T, Yokosawa S, Yamada S, Arakura N, Tanaka E, Nakayama J
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Journal Title
Histopathology
Volume: 64
Issue: 4
Pages: 536-546
DOI
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Peer Reviewed
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[Presentation] 胃粘液糖鎖と胃癌2012
Author(s)
中山淳
Organizer
第51回日本臨床細胞学会秋期大会
Place of Presentation
新潟市(招待講演)
Year and Date
2012-11-09
Related Report
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