Proteomics and immunohistochemical analyses of phosphorylation signaling in the tumor microenvironments for breast cancer progression
| Project/Area Number |
24390087
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUREBAYASHI Junich 川崎医科大学, 医学部, 教授 (10248255)
HANAMURA Noriko 三重大学, 医学部附属病院, 講師 (60437100)
KOZUKA Yuji 三重大学, 医学部附属病院, 講師 (50378311)
SHIMOJO Naoshi 三重大学, 医学部, 技術員 (70410751)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSAKO Hidetaka 徳島大学, 疾患酵素学研究センター, 教授 (10291171)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 乳癌 / 癌進展 / 微小環境 / プロテオミクス / リン酸化 / 癌幹細胞 |
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| Outline of Final Research Achievements |
During cancer progression,a step of increasing malignancy, cancer stroma formation as well as changes in cancer cells plays an important role . In the stroma, unique microenvironments formed by growth factors and extracellular matrix (ECM) are present. Tenascin -C (TNC) is known to be a specific ECM in cancer stroma, exhibiting various effects on not only cancer cells but also stromal cells. From the phosphoproteomic analysis of intracellular signals in cancer cells, TNC causes characteristic activation of SRC. Phosphorylation of several molecules on the downstream can be immunohistochemically detected in sections of breast cancer tissues, showing that both cancer cells and stromal cells are positive. The microenvironments of the cancer stroma with SRC activation may be a target for developing cancer treatments.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Tenascin C protects aorta from acute dissection in mice.2014
Author(s)
Kimura T, Shiraishi K, Furusho A, Ito S, Hirakata S, Nishida N, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Ikeda Y, Miyamoto T, Ueno T, Hamano K, Hiroe M, Aonuma K, Matsuzaki M, Imaizumi T, Aoki H.
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Journal Title
Sci Rep.
Volume: 4
Pages: 4051-4051
Related Report
Peer Reviewed / Open Access
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[Journal Article] The cell cycle profiling-risk score based on CDK1 and 2 predicts early recurrence in node-negative, hormone receptor-positive breast cancer treated with endocrine therapy.2014
Author(s)
Kim SJ, Masuda N, Tsukamoto F, Inaji H, Akiyama F, Sonoo H, Kurebayashi J, Yoshidome K, Tsujimoto M, Takei H, Masuda S, Nakamura S, Noguchi S.
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Journal Title
Cancer Lett.
Volume: 355
Issue: 2
Pages: 217-223
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma : comparison with female breast carcinoma2013
Author(s)
Takagi K, Moriya T, Kurosumi M, Oka K, Miki Y, Ebata A, Toshima T, Tsunekawa S, Takei H, Hirakawa H, Ishida T, Hayashi S, Kurebayashi J, Sasano H, Suzuki T
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Journal Title
Hormones and Cancer
Volume: 4(1)
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1/endothelin receptor A cascade
Author(s)
Fujita S, Shimojo N, Terasaki F, Otsuka K, Hosotani N, Kohda Y, Tanaka T, Nishioka T, Yoshida T, Hiroe M, Kitaura Y, Ishizaka N, Imanaka-Yoshida K.
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Journal Title
Heart Vessels.
Volume: (印刷中)
Related Report
Peer Reviewed
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[Presentation] 病理セミナー2014
Author(s)
小塚 祐司
Organizer
第２２回日本乳癌学会
Place of Presentation
大阪国際会議場、大阪市
Year and Date
2014-07-11
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