| Project/Area Number |
24390087
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUREBAYASHI Junich 川崎医科大学, 医学部, 教授 (10248255)
HANAMURA Noriko 三重大学, 医学部附属病院, 講師 (60437100)
KOZUKA Yuji 三重大学, 医学部附属病院, 講師 (50378311)
SHIMOJO Naoshi 三重大学, 医学部, 技術員 (70410751)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOSAKO Hidetaka 徳島大学, 疾患酵素学研究センター, 教授 (10291171)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
|---|
| Keywords | 乳癌 / 癌進展 / 微小環境 / プロテオミクス / リン酸化 / 癌幹細胞 |
|---|
| Outline of Final Research Achievements |
During cancer progression,a step of increasing malignancy, cancer stroma formation as well as changes in cancer cells plays an important role . In the stroma, unique microenvironments formed by growth factors and extracellular matrix (ECM) are present. Tenascin -C (TNC) is known to be a specific ECM in cancer stroma, exhibiting various effects on not only cancer cells but also stromal cells. From the phosphoproteomic analysis of intracellular signals in cancer cells, TNC causes characteristic activation of SRC. Phosphorylation of several molecules on the downstream can be immunohistochemically detected in sections of breast cancer tissues, showing that both cancer cells and stromal cells are positive. The microenvironments of the cancer stroma with SRC activation may be a target for developing cancer treatments.
|
