Comprehensive identification of new diagnostic and therapeutic targets of the esophago-gastric cancer to overcome therapy-resistant cancer stem cell and its clinical application

• Project/Area Number: 24390088
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: YASUI WATARU 広島大学, 医歯薬保健学研究院, 教授 (40191118)
• Co-Investigator(Renkei-kenkyūsha): OUE Naohide 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484) ; KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 胃癌 / 食道癌 / 治療耐性 / 癌幹細胞 / CAST法 / 診断・治療標的 / 消化管癌 / 治療抵抗性 / PCDHB9 / BST2 / 細胞生物学的機能 / FKTN / スキルス胃癌 / ZDHHC14

Outline of Final Research Achievements

As candidate diagnostic targets of esophago-gastric cancers associated with therapy-resistant cancer stem cells, TM9SF3, ZDHHC14, FKTN, PCDHB9, BST2, etc. were identified through comprehensive gene expression analysis using CAST method. The functional analysis revealed that they were possible therapeutic targets. Of the cancer stem cell markers of gastric cancer, ALDH1 was pointed out the possibility to play a role in metastasis of undifferentiated type gastric cancer. These findings will contribute to the application to the diagnosis and treatment for therapy-resistant cancer having tumor heterogeneity.

Research Products

• [Journal Article] Tetraspanin 8, identified by the Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer (2015)
  • Author(s): Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Naito Y, Oo HZ, Yasui W
  • Journal Title: Gastric Cance Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] New molecular staging with G-factor supplements TNM classification in gastric cancer: A multicenter collaborative research by the Japanese Society for Gastroenterological Carcinogenesis G-Project committee (2015)
  • Author(s): Sawada T, Yashiro M, Sentani K, Oue N, Yasui W, Miyazaki K, Kai K, Fushida S, Fujimura T, Ohira M, Kakeji Y, Natsugoe S, Shirabe K, Nomura S, Shimada Y, Tomita N, Hirakawa K, Maehara Y
  • Journal Title: Gastric Cancer Volume: 18 Issue: 1 Pages: 119-128
  • DOI: 10.1007/s10120-014-0338-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression (2014)
  • Author(s): Naohiro Uraoka, Naohide Oue, Naoya Sakamoto, Kazuhiro Sentani, Htoo Zarni Oo, Yutaka Naito, Tsuyoshi Noguchi, Wataru Yasui
  • Journal Title: Cancer Science Volume: 105 Issue: 1 Pages: 134-140
  • DOI: 10.1111/cas.12316
  • Peer Reviewed / Open Access
• [Journal Article] Identification of novel transmembrane proteins in scirrhous type gastric cancer by Escherichia coli ampicillin trap (CAST) method: TM9SF3 participates in tumor invasion and serves as a prognostic factor (2014)
  • Author(s): Oo HZ, Sentani K, Sakamoto N, Anami K, Naito Y, Oshima T, Yanagihara K, Oue N, Yasui W
  • Journal Title: Pathobiology Volume: 81 Issue: 3 Pages: 138-148
  • DOI: 10.1159/000357821
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method (2014)
  • Author(s): Shunsuke Shinmei, Kazuhiro Sentani, Tetsutaro Hayashi, Naoya Sakamoto, Keisuke Goto, Htoo Zarni Oo, Yutaka Naito, Jun Teishima, Akio Matsubara, Naohide Oue, Hiroki Kuniyasu, Wataru Yasui
  • Journal Title: Urologic Oncology Volume: 32 Issue: 6 Pages: 769-778
  • DOI: 10.1016/j.urolonc.2014.03.007
  • Peer Reviewed / Open Access
• [Journal Article] Expression of novel biomarkers identified by Escherichia coli ampicillin secretion trap: Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer (2014)
  • Author(s): Goto K, Oue N, Hayashi T, Shinmei S, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
  • Journal Title: Pathobiology Volume: 81 Issue: 4 Pages: 190-198
  • DOI: 10.1159/000363345
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer (2014)
  • Author(s): Htoo Zarni Oo, Kazuhiro Sentani, Naoya Sakamoto, Katsuhiro Anami, Yutaka Naito, Naohiro Uraoka, Takashi Oshima, Kazuyoshi Yanagihara, Naohide Oue, Wataru Yasui
  • Journal Title: Oncology Reports Volume: 32 Issue: 1 Pages: 403-410
  • DOI: 10.3892/or.2014.3166
  • Peer Reviewed
• [Journal Article] Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion (2014)
  • Author(s): Nobuaki Fujikuni, Hideki Yamamoto, Kazuaki Tanabe, Yutaka Naito, Naoya Sakamoto, Yuka Tanaka, Kazuyoshi Yanagihara, Naohide Oue, Wataru Yasui, Hideki Ohdan
  • Journal Title: Cancer Science Volume: 105 Issue: 11 Pages: 1411-1420
  • DOI: 10.1111/cas.12522
  • Peer Reviewed / Open Access
• [Journal Article] Canonical Wnt signals with suppressed TGFbeta/BMP pathways promote renewal of the native human colonic epithelium (2014)
  • Author(s): Reynolds A
  • Journal Title: Gut Volume: 63 Issue: 4 Pages: 610-623
  • DOI: 10.1136/gutjnl-2012-304067
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of MMP-7, lamininγ2 and EGFR at the invasive front of gastric carcinoma (2014)
  • Author(s): Sentani K
  • Journal Title: Gastric Cancer Volume: 印刷中
  • Peer Reviewed
• [Journal Article] MiR-148a is down-regulated in gastric cancer, targets MMP7 and indicates tumor invasiveness and poor prognosis (2014)
  • Author(s): Naoya Sakamoto, Yutaka Naito, Naohide Oue, Kazuhiro Sentani, Naohiro Uraoka, Htoo Zarni Oo, Kazuyoshi Yanagihara, Kazuhiko Aoyagi, Hiroki Sasaki, Wataru Yasui
  • Journal Title: Cancer Science Volume: 105 Issue: 2 Pages: 236-243
  • DOI: 10.1111/cas.12330
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous typoe gastric cancer (2014)
  • Author(s): Yutaka Naito, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Kazuyoshi Yanagihara, Kosei Hirakawa, Wataru Yasui
  • Journal Title: Cancer Science Volume: 105 Issue: 2 Pages: 228-235
  • DOI: 10.1111/cas.12329
  • Peer Reviewed / Open Access
• [Journal Article] New molecular staging with G-factor supplements TNM classification in gastric cancer: A multicenter collaborative research by the Japanese Society for Gastroenterological Carcinogenesis G-Project committee (2014)
  • Author(s): Sawada T
  • Journal Title: Gastric Cancer Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Signal peptidase complex 18, encodes by SEC11A, contributes to progression via TGF-a secretion in gastric cancer (2013)
  • Author(s): Naohide Oue, Yutaka Naito, Tetsutaro Hayashi, Misato Takigahira, Akiko Kawano-Nagatsuma, Kazuhiro Sentani, Naoya Sakamoto, Htoo Zarni Oo, Naohiro Uraoka, Kazuyoshi Yanagihara, Atsushi Ochiai, Hiroki Sasaki, Wataru Yasui
  • Journal Title: Oncogene Volume: 33 Issue: 30 Pages: 3918-3926
  • DOI: 10.1038/onc.2013.364
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological significance of MMP-7, lamininy2 and EGFR expression at the invasive front of gastric carcinoma (2013)
  • Author(s): Kazuhiro Sentani, Miho Matsuda, Naohide Oue, Naohiro Uraoka, Yutaka Naito, Naoya Sakamoto, Wataru Yasui
  • Journal Title: Gastric Cancer Volume: 17 Issue: 3 Pages: 412-422
  • DOI: 10.1007/s10120-013-0302-6
  • Peer Reviewed / Open Access
• [Journal Article] Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer (2013)
  • Author(s): Shinagawa K
  • Journal Title: Int J Cancer Volume: 132 Issue: 4 Pages: 813-823
  • DOI: 10.1002/ijc.27735
  • Peer Reviewed
• [Journal Article] Improved PCR amplification for molecular analysis using DNA from long-term preserved formalin-fixed, paraffin-embedded lung cancer tissue specimens (2013)
  • Author(s): Taga M
  • Journal Title: Int J Clin Exp Pathol Volume: 6 Pages: 76-79
  • Peer Reviewed
• [Journal Article] Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells. (2013)
  • Author(s): Mori R
  • Journal Title: Gastric Cancer Volume: 16 Issue: 3 Pages: 345-354
  • DOI: 10.1007/s10120-012-0191-0
  • Peer Reviewed
• [Journal Article] Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: a characteristic pattern is associated with sessile serrated lesion. (2013)
  • Author(s): Sentani K, Sakamoto N, Shimamoto F, Anami K, Oue N, Yasui W.
  • Journal Title: Histopathology Volume: - Issue: 7 Pages: 1018-1027
  • DOI: 10.1111/his.12099
  • Peer Reviewed
• [Journal Article] Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cance (2013)
  • Author(s): Onoyama M
  • Journal Title: Neoplasia Volume: 15 Pages: 1391-1399
  • Peer Reviewed
• [Journal Article] The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression. (2013)
  • Author(s): Hayashi T, Sentani K, Oue N, Ohara S, Teishima J, Anami K, Sakamoto N, Matsubara A, Yasui W.
  • Journal Title: Pathobiology Volume: 80 Issue: 2 Pages: 60-69
  • DOI: 10.1159/000341396
  • Peer Reviewed
• [Journal Article] Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells (2013)
  • Author(s): Mori R
  • Journal Title: Gastric Cancer Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Expression of podoplanin/D2-40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia (2013)
  • Author(s): Nakayama H
  • Journal Title: Med Mol Morphol Volume: 46 Issue: 1 Pages: 20-23
  • DOI: 10.1007/s00795-012-0004-x
  • Peer Reviewed
• [Journal Article] Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer. (2012)
  • Author(s): Wakamatsu Y, Sakamoto N, Oo HZ, Naito Y, Uraoka N, Anami K, Sentani K, Oue N, Yasui W.
  • Journal Title: Pathol Int Volume: 62 Issue: 2 Pages: 112-119
  • DOI: 10.1111/j.1440-1827.2011.02760.x
  • Peer Reviewed
• [Journal Article] Cytokeratin expression profiling in gastric carcinoma: clinicopathologic significance and comparison with tumor-associated molecules. (2012)
  • Author(s): Takami H, Sentani K, Matsuda M, Oue N, Sakamoto N, Yasui W.
  • Journal Title: Pathobiology Volume: 79 Issue: 3 Pages: 154-161
  • DOI: 10.1159/000335694
  • Peer Reviewed
• [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice. (2012)
  • Author(s): Hayashi, D., Tamura, A., Tanaka, H., Yamazaki, Y., Watanabe S. Suzuki, K., Suzuki, K. Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and Tsukita, S.
  • Journal Title: Gastroenterology Volume: 142 Issue: 2 Pages: 292-304
  • DOI: 10.1053/j.gastro.2011.10.040
  • Peer Reviewed
• [Journal Article] Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis. (2012)
  • Author(s): Sentani K, Oue N, Naito Y, Sakamoto N, Anami K, Oo HZ, Uraoka N, Aoyagi K, Sasaki H, Yasui W.
  • Journal Title: Carcinogenesis Volume: 33 Issue: 5 Pages: 1081-1088
  • DOI: 10.1093/carcin/bgs121
  • Peer Reviewed
• [Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer (2012)
  • Author(s): Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Naito Y, Oo HZ, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H, Yasui W.
  • Journal Title: Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer Volume: 103(9) Issue: 9 Pages: 1744-50
  • DOI: 10.1111/j.1349-7006.2012.02353.x
  • Peer Reviewed
• [Journal Article] Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. (2012)
  • Author(s): Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki, H, Yasui W.
  • Journal Title: PLoS One Volume: 7(11) Issue: 11 Pages: 47545-47545
  • DOI: 10.1371/journal.pone.0047545
  • Peer Reviewed
• [Journal Article] Claudin-based paracellular proton barrier in the stomach. (2012)
  • Author(s): Tamura A., et al
  • Journal Title: Ann N Y Acad Sci. Volume: 1,258 Issue: 1 Pages: 108-114
  • DOI: 10.1111/j.1749-6632.2012.06570.x
  • Peer Reviewed
• [Journal Article] Cytokeratin 7 is a Predictive Marker for Survival in Patients with Esophageal Squamous Cell Carcinoma (2011)
  • Author(s): Naohide Oue, Tsuyoshi Noguchi, Wataru Yasui.(他8名, 2番目)
  • Journal Title: Ann Surg Oncol. Volume: 19 Issue: 6 Pages: 1902-1910
  • DOI: 10.1245/s10434-011-2175-4
  • Peer Reviewed
• [Presentation] Molecular pathology of cancer cell growth and progression in gastrointestinal cancer (2015)
  • Author(s): Yasui W
  • Organizer: International Symposium on Tissue Microenvironmental Modulators
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2015-03-14
  • Invited
• [Presentation] Novel biomarkers and therapeutic targets of gastrointestinal cancer identified through transcriptome dissection (2015)
  • Author(s): Yasui W
  • Organizer: The 2nd International Symposium of Hiroshima Research Center for Healthy Ageing
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2015-03-13
  • Invited
• [Presentation] 世界の胃癌診療における日本の病理の役割：過去・現在・未来 (2015)
  • Author(s): 安井 弥
  • Organizer: 第87回日本胃癌学会総会
  • Place of Presentation: 広島
  • Year and Date: 2015-03-04 – 2015-03-06
  • Invited
• [Presentation] トランスクリプトームダイセクションによって同定した胃がんの新規診断・治療標的 (2014)
  • Author(s): 安井 弥、大上直秀、Htoo Zarni Oo、向井正一朗、仙谷和弘
  • Organizer: 第73回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] ポドプラニンは食道扁平上皮癌において放射線化学療法の効果予測に有効である (2014)
  • Author(s): 大上直秀、仙谷和弘、浦岡直礼、服部拓也、安井 弥
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 食道扁平上皮癌におけるolfactomedin4の発現解析 (2014)
  • Author(s): 浦岡直礼、大上直秀、仙谷和弘、服部拓也、野口 剛、安井 弥
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 胃癌におけるBST2の発現と機能 (2014)
  • Author(s): 向井正一朗、大上直秀、Htoo Zarni Oo、仙谷和弘、大段秀樹、安井 弥
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 網羅的解析から同定した胃癌関連遺伝子の臨床的意義と幹細胞における役割 (2014)
  • Author(s): 大上直秀、安井 弥
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Novel biomarkers and therapeutic targets for gastric cancer (2014)
  • Author(s): Yasui W
  • Organizer: The 7th Annual Scientific Meeting of the Singapore Gastric Cancer Consortium
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2014-07-23 – 2014-07-24
  • Invited
• [Presentation] Functional analysis of BST2 in gastric cancer, identified by CAST method (2014)
  • Author(s): 向井正一朗、大上直秀、Htoo Zarni Oo、仙谷和弘、大段秀樹、安井 弥
  • Organizer: 第23回日本がん転移学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] SAGE法・CAST法から明らかとなった胃癌における分泌および細胞表面蛋白と胃型・腸型形質との関連 (2014)
  • Author(s): 大上直秀、仙谷和弘、浦岡直礼、服部拓也、安井 弥
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] SAGE法により同定された食道扁平上皮癌の新規マーカーNRD1の発現 (2014)
  • Author(s): 浦岡直礼、坂本直也、大上直秀、仙谷和弘、Oo Htoo Zarni、内藤 寛、野口 剛、安井 弥
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 胃癌における細胞表面蛋白質TSPAN8の発現とその意義 (2014)
  • Author(s): 服部拓也、大上直秀、仙谷和弘、Htoo Zarni Oo、阿南勝宏、安井 弥
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] CAST法により同定した細胞表面蛋白質BST2の胃癌における異常 (2014)
  • Author(s): 向井正一朗、大上直秀、仙谷和弘、Oo Htoo Zarni、安井 弥
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] CAST法を用いて同定したBST2の大腸癌における発現・機能解析 (2014)
  • Author(s): 向井理沙、Oo Htoo Zarni、向井正一朗、仙谷和弘、大上直秀、安井 弥
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] SEC11A contributes to malignant progression through promotion of EGF and TGF-alpha secretion (2013)
  • Author(s): Oue N
  • Organizer: The 104th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Washington D.C. (USA)
• [Presentation] Biomarker for gastric cancer (2013)
  • Author(s): Yasui W
  • Organizer: Commemorative Symposium for the 2nd anniversary of SNUCH
  • Place of Presentation: Seoul (Korea)
  • Invited
• [Presentation] HP and carcinogenesis –Pathogenesis and novel diagnostic and therapeutic target (2013)
  • Author(s): Yasui W
  • Organizer: 10th International Gastric Cancer Congress
  • Place of Presentation: Verona (Italy)
  • Invited
• [Presentation] Search for biomarkers of stage II/III gastric cancer and development of individualized therapy (2013)
  • Author(s): Oshima T
  • Organizer: 10th International Gastric Cancer Congress
  • Place of Presentation: Verona (Italy)
• [Presentation] Novel biomarkers and therapeutic targets of gastric cancer (2013)
  • Author(s): Yasui W
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: Urayasu, Chiba (Japan)
  • Invited
• [Presentation] Combining molecular target drugs to inhibit cancer-stromal cell interaction in gastric cancer (2013)
  • Author(s): Onoyama M
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: Urayasu, Chiba (Japan)
• [Presentation] CAST法を用いた胃癌細胞表面マーカーの同定：TSPAN8の胃癌における解析 (2013)
  • Author(s): 大上直秀
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] 高腹膜播種能を有するスキルス胃癌細胞株44As3を用いたCAST解析 (2013)
  • Author(s): Htoo Zarni Oo
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] 大腸癌におけるTransmembrane 9 super family member 3（TM9SF3）の発現とβ-カテニンとの関連 (2013)
  • Author(s): 坂本直也
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] SAGE法による食道扁平上皮癌の新規マーカーNRD1の同定 (2013)
  • Author(s): 浦岡直礼
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] スキルス胃癌の分子病理と治療標的 (2013)
  • Author(s): 安井 弥
  • Organizer: 第85回日本胃癌学会総会
  • Place of Presentation: 大阪(招待講演)
• [Presentation] 胃癌の分子・遺伝子を標的とした診断 (2013)
  • Author(s): 安井 弥
  • Organizer: 第85回日本胃癌学会総会
  • Place of Presentation: 大阪(招待講演)
• [Presentation] これからの日本の胃癌はどうなるか : 病理学的見地から (2013)
  • Author(s): 安井 弥
  • Organizer: 第85回日本胃癌学会総会
  • Place of Presentation: 大阪(招待講演)
• [Presentation] Novel biomarkers of gastric cancer identified by SAGE data analysis (2012)
  • Author(s): Yasui W
  • Organizer: Korea-Japan Cancer Workshop on Gastric Cancer and Liver Cancer
  • Place of Presentation: Busan (Korea)(招待講演)
  • Year and Date: 2012-11-30
• [Presentation] Alteration of microRNA expression in gastrointestinal cancer (2012)
  • Author(s): Oue N
  • Organizer: THe 22^<nd> Hiroshima Cancer Seminar and the 4^<th> Japanese Association for RNA interference Joint International Symposium
  • Place of Presentation: Hiroshima (Japan)(招待講演)
  • Year and Date: 2012-08-30
• [Presentation] Molecular pathology of gastric cancer - microRNA and novel diagnostic & therapeutic targets (2012)
  • Author(s): Yasui W
  • Organizer: The 96^<th> Annual Meeting of the German Society of Pathology
  • Place of Presentation: Berlin (Germany),(招待講演)
• [Presentation] Molecular targets for diagnosis and therapeutics of gastric cancer - Present and future (2012)
  • Author(s): Yasui W
  • Organizer: 17^<th> Japan-Korea Cancer Research Workshop
  • Place of Presentation: Busan (Korea)(招待講演)
• [Presentation] 消化管がんの発生と制御・形態の理解における統括病理学 (2012)
  • Author(s): 安井 弥
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京(招待講演)
• [Presentation] 消化管がんの新規診断・治療開発に向けた分子病理学的アプローチ (2012)
  • Author(s): 安井 弥
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 広島
• [Presentation] 胃癌研究のマイルストーンと今後の展望 (2012)
  • Author(s): 安井 弥
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌(招待講演)
• [Book] Principle of molecular diagnostics and personalized cancer medicine (2013)
  • Author(s): Yasui W
  • Total Pages: 968
  • Publisher: Lippincott Williams & Wilkins
• [Remarks] 広島大学大学院医歯薬保健学研究院分子病理学研究室
  • URL: http://home.hiroshima-u.ac.jp/byori1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byori1/