Study on dynamics and function of basophils by using intravital imaging

• Project/Area Number: 24390093
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KARASUYAMA Hajime 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60195013)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 好塩基球 / 生体イメージング / 細胞遊走 / マスト細胞 / 脱顆粒 / 好酸球

Outline of Final Research Achievements

We have established Mcpt8GFP mice in that only basophils express green fluorescence protein (GFP), making it possible to visualize the localization and migration of basophils in vivo by using confocal microscopy. Analysis of these mice identified the interaction of basophils with monocytes and macrophages, and demonstrated that basophil-derived IL-4 acts on tissue-infiltrating monocytes to promote their differentiation to type 2 macrophages which play important roles in parasite expulsion and termination of inflammation.

Research Products

• [Journal Article] The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. (2015)
  • Author(s): Tsai, S-H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.
  • Journal Title: Immunity Volume: 42(2) Issue: 2 Pages: 279-293
  • DOI: 10.1016/j.immuni.2015.01.015
  • Peer Reviewed / Open Access
• [Journal Article] 最近明らかになってきた好塩基球の役割 (2015)
  • Author(s): 三宅健介、烏山 一
  • Journal Title: 臨床免疫・アレルギー科 Volume: 63 Pages: 164-169
  • NAID: 40020362722
• [Journal Article] CD41 is a reliable identification and activation marker for murine basophils in the steady-state and during helminth and malarial infections (2014)
  • Author(s): Bakocevic, N., Claser, C., Yoshikawa, S., Jones, LA., Chew, S., Goh. CC., Malleret, B., Larbi, A., Ginhoux, F., de Lafaille, MC., Karasuyama, H., Renia, L., Ng, LG
  • Journal Title: Eur. J. Immunol. Volume: 44 Issue: 6 Pages: 1823-1834
  • DOI: 10.1002/eji.201344254
  • Peer Reviewed
• [Journal Article] NADPH oxidase-independent formation of extracellular DNA traps by basophils (2014)
  • Author(s): Morshed, M., Hlushchuk, R., Simon, D., Walls, A.F., Obata-Ninomiya, K., Karasuyama, H., Djonov, V., Eggel, A., Kaufmann, T., Simon, H-U, and Yousefi, S.
  • Journal Title: J. Immunol. Volume: 192 Issue: 11 Pages: 5314-5323
  • DOI: 10.4049/jimmunol.1303418
  • Peer Reviewed
• [Journal Article] Contribution of mast cell-derived IL-1β to uric acid crystal-induced acute arthritis in mice (2014)
  • Author(s): Reber, L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L.B., Robinson, W.H., Tsai, M., and Galli, S.J.
  • Journal Title: Arthritis Rheum. Volume: 66 Issue: 10 Pages: 2881-2891
  • DOI: 10.1002/art.38747
  • Peer Reviewed
• [Journal Article] Basophils have emerged as a key player in immunity (2014)
  • Author(s): Karasuyama, H., and Yamanishi, Y.
  • Journal Title: Curr. Opin. Immunol. Volume: 31 Pages: 1-7
  • DOI: 10.1016/j.coi.2014.07.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Basophil-derived IL-4 induces the differentiation of inflammatory monocytes into M2-type macrophages to dampen allergic inflammation (2014)
  • Author(s): Egawa, M., Mukai, K., and Karasuyama, H.
  • Journal Title: Allergic diseases: from mechanisms to cures Volume: 1 Pages: 59-62
• [Journal Article] 消化管寄生虫感染防御免疫応答における好塩基球の新たな役割 (2014)
  • Author(s): 二宮（小畑）一茂、筒井英充、烏山 一
  • Journal Title: 感染・炎症・免疫 Volume: 44 Pages: 30-39
• [Journal Article] 免疫システムのキープレイヤー・好塩基球とアレルギー炎症のメカニズム (2014)
  • Author(s): 壹岐美紗子、烏山 一
  • Journal Title: 実験医学 Volume: 32 Pages: 2728-2733
• [Journal Article] 好塩基球の光と影「はじめに」 (2014)
  • Author(s): 烏山 一
  • Journal Title: 医学のあゆみ Volume: 250 Pages: 1079-1079
• [Journal Article] マダニ感染防御と好塩基球 (2014)
  • Author(s): 太田卓哉、吉川宗一郎、烏山 一
  • Journal Title: 医学のあゆみ Volume: 250 Pages: 1114-1118
• [Journal Article] Activation of basophils by the double-stranded RNA poly(A:U) exacerbates allergic inflammation (2013)
  • Author(s): Ramadan, A., Pham, Van L., Machavoine, F., Dietrich, C., Alkan, M., Karasuyama, H., Schneider, E., Dy, M., Thieblemont, N.
  • Journal Title: Allergy Volume: 68 Issue: 6 Pages: 732-738
  • DOI: 10.1111/all.12151
  • Peer Reviewed
• [Journal Article] Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis (2013)
  • Author(s): Torrero, M.N., Morris, C.P., Mitre, B.K., Hübner, M.P., Mueller, E., Karasuyama, H., and Mitre, E.
  • Journal Title: Vaccine Volume: 31 Issue: 36 Pages: 3675-3682
  • DOI: 10.1016/j.vaccine.2013.06.010
  • Peer Reviewed
• [Journal Article] Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice (2013)
  • Author(s): Reber, L.L., Marichal, T., Mukai, K., Roers, A., Hartmann, K., Karasuyama, H., Nadeau, K.C., Tsai, M., and Galli, S.J.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 132 Issue: 4 Pages: 881-888
  • DOI: 10.1016/j.jaci.2013.06.008
• [Journal Article] Heterogeneous immunologic pathways underlie the pathogenesis of the allergic march (2013)
  • Author(s): Noti, M., Tait, E.D., Wojno, T., Kim, B. S. Siracusa, M.C., Giacomin, P.R., Nair, M.G., Kubo, M., Alain J. Benitez, A.J., Ruymann, K.R., Comeau, M.R., Cianferoni, A., Wang, M., Spergel, J.S., and Artis, D
  • Journal Title: Nature Medicine Volume: 19(8) Issue: 8 Pages: 1005-1013
  • DOI: 10.1038/nm.3281
  • Peer Reviewed
• [Journal Article] Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation (2013)
  • Author(s): Anyan, W.K., Seki, T., Kumagai, T., Obata-Ninomiya, K., Furushima-Shimogawara, R., Kwansa-Bentum, B., Akao, N., Bosompem, K.M., Boakye, D.A., Wilson, M.D., Karasuyama, H., and Ohta, N.
  • Journal Title: Parasitol. Int. Volume: 62 Issue: 6 Pages: 508-513
  • DOI: 10.1016/j.parint.2013.07.003
  • Peer Reviewed
• [Journal Article] The skin is an important bulwark of acquired immunity against intestinal helminths (2013)
  • Author(s): Obata-Ninomiya, K., Ishiwata, K., Tsutsui, H., Nei, Y., Yoshikawa, S., Kawano, Y., Minegishi, Y., Ohta, N., Watanabe, N., Kanuka, H., and Karasuyama, H.
  • Journal Title: J. Exp. Med. Volume: 210 Issue: 12 Pages: 2583-2595
  • DOI: 10.1084/jem.20130761
  • Peer Reviewed
• [Journal Article] GATA-1 regulates the generation and function of basophils (2013)
  • Author(s): Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Issue: 46 Pages: 18620-5
  • DOI: 10.1073/pnas.1311668110
  • Peer Reviewed
• [Journal Article] Skin TSLP initiates Th2 responses through an orchestrated immune cascade (2013)
  • Author(s): Leyva-Castillo, J.M., Hener, P., Michea, P., Karasuyama, H., Chan, S., Soumelis, V., and Li, M.
  • Journal Title: Nat. Commun. Volume: 4 Issue: 1 Pages: 2847-2847
  • DOI: 10.1038/ncomms3847
  • Peer Reviewed
• [Journal Article] IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses (2013)
  • Author(s): Kim, S., Karasuyama, H., Lopez, AF., Ouyang, W., Li, X., Le Gros, G., and Min, B.
  • Journal Title: Immune Netw. Volume: 13 Issue: 6 Pages: 249-256
  • DOI: 10.4110/in.2013.13.6.249
  • Peer Reviewed
• [Journal Article] アレルギーの基礎研究－好塩基球の研究最前線から (2013)
  • Author(s): 吉川宗一郎、烏山 一
  • Journal Title: 医学のあゆみ Volume: 247 (13) Pages: 1208-1212
• [Journal Article] 好塩基球とアレルギー (2013)
  • Author(s): 吉川 宗一郎、烏山 一
  • Journal Title: アレルギー Volume: 62 (7) Pages: 797-804
• [Journal Article] 炎症性単球の分化とアレルギー炎症の抑制 (2013)
  • Author(s): 江川 真由美、烏山 一
  • Journal Title: BIOS Volume: 18 (4) Pages: 7-8
• [Journal Article] 好塩基球による慢性アレルギー炎症の誘導機構 (2013)
  • Author(s): 壹岐 美紗子、烏山 一
  • Journal Title: 炎症と免疫 Volume: 21（6） Pages: 78-82
• [Journal Article] Sequential engagement of FceRI on mast cells and basophil histamine H4 receptor and fceri in allergic rhinitis (2013)
  • Author(s): Shiraishi, Y., et al.
  • Journal Title: J. Immunol. Volume: 190 Issue: 2 Pages: 539-548
  • DOI: 10.4049/jimmunol.1202049
  • Peer Reviewed
• [Journal Article] Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleu kin-4 (2013)
  • Author(s): Egawa,M., et al.
  • Journal Title: Immunity Volume: 38 Pages: 570-580
  • Peer Reviewed
• [Journal Article] Melanocortin Receptors 1 and 5 might mediate inhibitory effects of α-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice (2012)
  • Author(s): Etori, M.
  • Journal Title: J.Invest.Dermatol. Volume: 132 Issue: 7 Pages: 1925-1927
  • DOI: 10.1038/jid.2012.68
  • Peer Reviewed
• [Journal Article] Critical role of P1-Runx1 in mouse basophil development (2012)
  • Author(s): Mukai, K., et al.
  • Journal Title: Blood Volume: 120 Pages: 76-85
  • Peer Reviewed
• [Journal Article] Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneo us reverse passive Arthus reaction. (2012)
  • Author(s): Jin G, Matsushita T, Hamaguchi Y, Le H uu D, Ishii T, Hasegawa M, Obata K Kar asuyama H, Takehara K, Fujimoto M
  • Journal Title: J Dermatol Sci. Volume: 67 (3) Issue: 3 Pages: 181-189
  • DOI: 10.1016/j.jdermsci.2012.06.005
  • Peer Reviewed
• [Journal Article] 好塩基球研究のアップデート (2012)
  • Author(s): 江川真由美、烏山一
  • Journal Title: 実験医学 Volume: 30 (6) Pages: 905-911
• [Journal Article] 好塩基球研究の進展 (2012)
  • Author(s): 壹岐美紗子、烏山一
  • Journal Title: 医学のあゆみ Volume: 243 (1) Pages: 78-83
• [Journal Article] 好塩基球研究のルネッサンス (2012)
  • Author(s): 吉川宗一郎、鳥山一
  • Journal Title: 化学と生物 Volume: 10月号 Pages: 717-722
• [Journal Article] アレルギー疾患における好塩基球の働き (2012)
  • Author(s): 吉川宗一郎、烏山一
  • Journal Title: アレルギーの臨床 Volume: 434 (32) Pages: 37-41
• [Presentation] 好塩基球研究のめざましい進展～日陰者がいっきに檜舞台に躍り出た！ (2015)
  • Author(s): 烏山 一
  • Organizer: 第78回日本皮膚科学会東京支部学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-21
  • Invited
• [Presentation] Non-redundant roles of basophils in Th2-type protective immunity and allergy (2014)
  • Author(s): Karasuyama, H.
  • Organizer: Cell Symposium “The multifaceted roles of type 2 immunity”
  • Place of Presentation: Bruges, Belgium
  • Year and Date: 2014-12-11
  • Invited
• [Presentation] IL-3 induces the expression of G-protein-coupled receptors on basophil, leading to their infiltration to tick-feeding site (2014)
  • Author(s): Ohta, T., Yoshikawa, S., Okayama, N., Ishiwata, K., Yamaji, K., Horiguchi, K., Li Lihua, Kawano, Y., Yamanishi, Y., Kanuka, H., Watanabe, N., Karasuyama, H.
  • Organizer: The 43th Annual Meeting of JSI
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] GM-CSF-elicited basophils have increased capacity for antigen presentation (2014)
  • Author(s): Miyake, K. Nagao, T., Yahagi, Y., Numazaki, T., Yoshikawa, S., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 43th Annual Meeting of JSI
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Establishment of a novel fluorogenic indicator for mast cell degranulation (2014)
  • Author(s): Horiguchi, K., Yoshikawa, S., Li, L., Ohta, T., Gero, M., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 43th Annual Meeting of JSI
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Basophil-derived mouse mast cell protease 11 contributes to the development of IgE-mediated chronic allergic inflammation via COX-2 (2014)
  • Author(s): Tanaka, K., Iki, M., Deki H., Sato, S., Yoshikawa, S., Yamashini, Y., Karasuyama, H.
  • Organizer: The 43th Annual Meeting of JSI
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Molecular mechanism underlying Ca2+ influx due to IgE/antigen stimulation in basophils (2014)
  • Author(s): Yoshikawa, S., Ohora, M., Miyake, K., Li, L., Horiguchi, K., Ohta, T., Adachi, T., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 43th Annual Meeting of JSI
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Emerging roles of basophils in allergy and protective immunity (2014)
  • Author(s): Karasuyama, H.
  • Organizer: Medical Research Institute 40th Anniversary Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] Basophils have emerged as a key player in immunity (2014)
  • Author(s): Karasuyama, H.
  • Organizer: The 24th Hot Spring Harbor International Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2014-11-08
  • Invited
• [Presentation] Non-redundant roles for basophils in allergy and protective immunity (2014)
  • Author(s): Karasuyama, H.
  • Organizer: British Society for Immunology Congress 2014
  • Place of Presentation: Briton, UK
  • Year and Date: 2014-11-02
  • Invited
• [Presentation] アレルギー発症における好塩基球の役割とその制御 (2014)
  • Author(s): 烏山 一
  • Organizer: 第74回臨床アレルギー研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-01
  • Invited
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2014)
  • Author(s): 烏山 一
  • Organizer: 日本眼科アレルギー研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04
  • Invited
• [Presentation] アレルギー発症における好塩基球の役割とその制御 (2014)
  • Author(s): 烏山 一
  • Organizer: 第42回日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-25
  • Invited
• [Presentation] Basophils have emerged as a key player in immunity (2014)
  • Author(s): Karasuyama, H.
  • Organizer: Cold Spring Harbor Asia Conference “Frontiers of Immunology in Health & Diseases”
  • Place of Presentation: Suzhou, China
  • Year and Date: 2014-09-04
  • Invited
• [Presentation] Non-redundant roles of basophils in immunity-a neglected minority gains new respect (2014)
  • Author(s): Karasuyama, H.
  • Organizer: The 24th Congress of Interasma Japan/North Asia
  • Place of Presentation: Nagoya
  • Year and Date: 2014-07-19
  • Invited
• [Presentation] アレルギー疾患ならびに生体防御における好塩基球の新たな役割 (2014)
  • Author(s): 烏山 一
  • Organizer: 第41回本郷呼吸器研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-24
  • Invited
• [Presentation] アレルギーならびに生体防御における好塩基球の役割 (2014)
  • Author(s): 烏山 一
  • Organizer: 第79回インターフェロン・サイトカイン学会
  • Place of Presentation: 札幌
  • Year and Date: 2014-06-19
  • Invited
• [Presentation] アレルギーに関連する新規の免疫細胞～ILC2細胞と好塩基球を中心として～ (2014)
  • Author(s): 烏山 一
  • Organizer: 第26回アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-10
  • Invited
• [Presentation] 好塩基球トリプターゼmMCP-11は慢性皮膚アレルギー炎症における重要なエフェクター分子である (2014)
  • Author(s): 田中謙成、出来隼人、烏山 一
  • Organizer: 第26回アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] GM-CSFによって誘導した骨髄由来好塩基球は抗原提示能を有する (2014)
  • Author(s): 三宅健介、吉川宗一郎、矢作雄人、烏山 一
  • Organizer: 第26回アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2013)
  • Author(s): 鳥山一
  • Organizer: 第14回京都アレルギークロストーク
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2013-02-21
• [Presentation] Basophils as a crucial player in acquired immune responses (2013)
  • Author(s): Karasuyama, H.
  • Organizer: Keystone Symposium "Th2 Immunity"
  • Place of Presentation: Santa Fe, USA(招待講演)
  • Year and Date: 2013-01-13
• [Presentation] A mechanism of the skin-infiltration of basophils that is essential for the acquired protective immunity to tick infestation (2013)
  • Author(s): Yoshikawa, S., Ohta, T., Ishiwata, K., Horiguchi, K., Li, L., Kawano, Y., Kanuka, H., Watanabe, N., Karasuyama, H.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Basophils contribute to the Th2-type protective immunity against re-infection with intestinal helminthes (2013)
  • Author(s): Obata-Ninomiya, K., Ttsutsui, H., Ishiwata, K., Watanabe, N., Kanuka, H., Karasuyama, H.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Intravenous injection of particulate antigens larger than the intracellular gap of endothelial cells can induce mast cell-mediated systemic anaphylaxis (2013)
  • Author(s): Li, L., Yoshikawa, S., Horiguchi, K., Ohta, T., Deki, H., Kawano, Y., Karasuyama, H.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] IgE-armed basophils and their skin infiltration are essential for acquired tick resistance (2013)
  • Author(s): Ohta, T., Yoshikawa, S., Ishiwata, K., I Horiguchi, K., Li, L., Kawano, Y., Kanuka, H., Watanabe, N., Karasuyama, H.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Basophil-derived mouse mast cell protease 11 is involved in the development of IgE-mediated chronic allergic inflammation (2013)
  • Author(s): Deki, H., Kawano, Y., Yoshikawa, S., Iki, M., Egawa, M., Ohta, T., Karasuyama, H.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] STIM1-mediated store operated Ca2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation (2013)
  • Author(s): Yoshikawa, S., Oh-hora, M., Miyake, K., Li, L., Ohta, T., Adachi, T., Horiguchi, K., Kawano, Y., Karasuyama, H.
  • Organizer: The 42th Annual Meeting of JSI
  • Place of Presentation: 千葉県千葉市 幕張メッセ
• [Presentation] Basophil-elicited arginase-1+ M2-type macrophages play a pivotal role in acquired protection against helminthic infection (2013)
  • Author(s): Obata, K., Tsutsui, H., Ishiwata, K., Kanuka, H., Watanabe, N., Karasuyama, H.
  • Organizer: The 42th Annual Meeting of JSI
  • Place of Presentation: 千葉県千葉市 幕張メッセ
• [Presentation] CD4+ T cell-derived IL-3 is essential for basophil recruitment to tick-feeding sites during re-infestation (2013)
  • Author(s): Ohta, T., Yoshikawa, S., Ishiwata, K., Horiguchi, K., Li, L., Kawano, Y., Kanuka, H., Watanabe, N., Karasuyama, H.
  • Organizer: The 42th Annual Meeting of JSI
  • Place of Presentation: 千葉県千葉市 幕張メッセ
• [Presentation] Basophil-derived mouse mast cell protease 11 is a key effector molecule in the development of IgE-mediated chronic allergic inflammation (2013)
  • Author(s): Deki, H., Kawano, Y., Yoshikawa, S., Iki, M., Karasuyama, H.
  • Organizer: The 42th Annual Meeting of JSI
  • Place of Presentation: 千葉県千葉市 幕張メッセ
• [Presentation] STIM1を介したストア作動性カルシウム流入は好塩基球の脱顆粒および炎症局所への浸潤に重要である (2013)
  • Author(s): 三宅健介、吉川宗一郎、大洞将嗣、烏山一
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京都千代田区 ホテルニューオータニ
• [Presentation] 好塩基球トリプターゼmMCP-11は慢性皮膚アレルギー炎症における重要なエフェクター分子である (2013)
  • Author(s): 出耒隼人、河野洋平、吉川宗一郎、壹岐美紗子、烏山一
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京都千代田区 ホテルニューオータニ
• [Presentation] 好塩基球トリプターゼmMCP-11は慢性皮膚アレルギー炎症における重要なエフェクター分子である (2013)
  • Author(s): 出耒隼人、河野洋平、吉川宗一郎、壹岐美紗子、烏山一
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市 神戸ポートアイランド
• [Presentation] 新たに脚光を浴びる好塩基球 (2012)
  • Author(s): 鳥山一
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2012-11-30
• [Presentation] アレルギー疾患ならびに生体防御における好塩基球の役割 (2012)
  • Author(s): 鳥山一
  • Organizer: 第76回小児アレルギー同好会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-11-10
• [Presentation] アレルギー疾患ならびに生体防御における好塩基球の役割 (2012)
  • Author(s): 鳥山一
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2012-10-21
• [Presentation] アレルギー疾患ならびに寄生虫感染症における好塩基球の役割 (2012)
  • Author(s): 鳥山一
  • Organizer: 第51回日本鼻科学会
  • Place of Presentation: 幕張(招待講演)
  • Year and Date: 2012-09-27
• [Presentation] 皮膚のアレルギー炎症ならびに寄生虫感染症における好塩基球の役割 (2012)
  • Author(s): 烏山一
  • Organizer: 第42回日本皮膚アレルギー・接触皮膚炎学会
  • Place of Presentation: 軽井沢(招待講演)
  • Year and Date: 2012-07-14
• [Presentation] The role of basophils revisited (2012)
  • Author(s): Karasuyama, H.
  • Organizer: EAACI Congress 2012
  • Place of Presentation: Geneva, Switzerland(招待講演)
  • Year and Date: 2012-06-17
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2012)
  • Author(s): 烏山一
  • Organizer: 第24回日本アレルギー学会春季臨床大会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2012-05-12
• [Presentation] Emerging roles for basophils in protective and pathological immune responses (2012)
  • Author(s): Karasuyama, H.
  • Organizer: Innovation Summit Tokyo 2012
  • Place of Presentation: Tokyo(招待講演)
  • Year and Date: 2012-04-18
• [Presentation] Emerging roles for basophils in Immunity (2012)
  • Author(s): Karasuyama, H.
  • Organizer: The 20 12 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2012-04-13
• [Presentation] STIM1 plays essential roles for basophil recruitment in IgE-mediated chronic allergic inflammation (2012)
  • Author(s): Yoshikawa S, et al.
  • Organizer: The 41th JSI Symposium
  • Place of Presentation: Kobe
• [Presentation] Basophils rather than eosinophils and mast cells play an imp ortant role in acquired protection against helminthic infection (2012)
  • Author(s): Obata-Ninomiya K., et al.
  • Organizer: The 41th JSI Symposium
  • Place of Presentation: Kobe
• [Presentation] Ly-6C^+CCR2^+ monocytes differentiate to M2-type macrophages in a basophil IL-4-dependent manner and dampen lgE-mediated chronic allergic inflammation (2012)
  • Author(s): Egawa, M., et al.
  • Organizer: The 41th JSI Symposium
  • Place of Presentation: Kobe
• [Presentation] CD4^+T cells are required for basophil migration to tick-feeding sites during secondary tick infestation (2012)
  • Author(s): Ohta T, et al.
  • Organizer: The 41th JSI Symposium
  • Place of Presentation: Kobe
• [Presentation] Non-redundant roles of basophils in immunity
  • Author(s): Karasuyama, H.
  • Organizer: EAACI-WAO Congress 2013
  • Place of Presentation: Milan, Italy
  • Invited
• [Presentation] Role of basophils in allergic responses and protective immunity
  • Author(s): Karasuyama, H.
  • Organizer: German-Japan Immunology Seminar
  • Place of Presentation: 静岡県静岡市 日本平ホテル
  • Invited
• [Presentation] Emerging roles for basophils in immunity: a neglected minority gains new respect
  • Author(s): Karasuyama, H.
  • Organizer: NIF Winter School on Advanced Immunology
  • Place of Presentation: 兵庫県淡路市 淡路夢舞台国際会議場
  • Invited
• [Presentation] Emerging roles for basophils in health and disease
  • Author(s): Karasuyama, H.
  • Organizer: The 3rd Bizan Immunology Symposium
  • Place of Presentation: 徳島県徳島市 徳島大学
  • Invited
• [Presentation] Role of basophils in allergic inflammation and protective immunity
  • Author(s): Karasuyama, H.
  • Organizer: ERS Lung Science Conference
  • Place of Presentation: Estoril, Portugal
  • Invited
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割～日陰者が一気に檜舞台に
  • Author(s): 烏山 一
  • Organizer: BIOtech2013
  • Place of Presentation: 東京都江東区 東京ビックサイト
  • Invited
• [Presentation] 希少細胞を標的としたアレルギー治療ならびに寄生虫ワクチン開発に向けた基盤研究
  • Author(s): 烏山 一
  • Organizer: ゲノム創薬フォーラム
  • Place of Presentation: 東京都港区 東京大学医科学研究所講堂
  • Invited
• [Presentation] 好塩基球はマダニ感染に対する抵抗性獲得に必須である
  • Author(s): 烏山 一
  • Organizer: 第８７回日本細菌学会
  • Place of Presentation: 東京都江戸川区 タワーホール船堀
  • Invited
• [Presentation] 消化管寄生線虫Nippostrongylus brasiliensisの再感染防御における皮膚の役割
  • Author(s): 二宮(小畑)一茂、石渡賢治、筒井英充、渡邊直煕、太田伸生、嘉糠洋陸、烏山一
  • Organizer: 第73回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京都台東区 国立科学博物館上野本館
• [Presentation] 好塩基球によって誘導されるM2型マクロファージによる消化管寄生線虫Nippostrongylus brasiliensis感染防御応答
  • Author(s): 二宮(小畑)一茂、石渡賢治、筒井英充、渡邊直煕、太田伸生、嘉糠洋陸、烏山一
  • Organizer: 第83回日本寄生虫学会大会
  • Place of Presentation: 愛媛県松山市 愛媛大学城北キャンパス
• [Presentation] Mechanism underlying basophil infiltration to tick-feeding sites for protective immunity to tick re-infection
  • Author(s): 太田卓也、吉川宗一郎、石渡 賢治、堀口華代、李麗華、嘉糠 洋陸、渡邊 直煕、河野洋平、烏山 一
  • Organizer: 第83回日本寄生虫学会大会
  • Place of Presentation: 愛媛県松山市 愛媛大学城北キャンパス
• [Book] 慢性炎症と疾患-好塩基球とマクロファージによるアレルギー炎症の鎮静化 (2013)
  • Author(s): 江川 真由美、烏山 一
  • Publisher: BIO Clinica
• [Book] 免疫学Update -分子病態の解明と治療への展開 (2012)
  • Author(s): 烏山一
  • Total Pages: 252
  • Publisher: 南山堂
• [Remarks] 免疫アレルギー学分野
  • URL: http://immune-regulation.org
• [Remarks] Department of Immune Regulation
  • URL: http://immune-regulation.org/index.php?id=27
• [Remarks] 免疫アレルギー学
  • URL: http://www.med.tmd.ac.jp/medicine/list/basic/functional/imm_regulation.html
• [Remarks] 免疫アレルギー学分野
  • URL: http://immune-regulation.org
• [Remarks]
  • URL: http://immune-regulation.org