Establishing preventive strategy for mesothelioma by elucidating its carcinogenic mechanism
| Project/Area Number |
24390094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
TOYOKUNI SHINYA 名古屋大学, 医学(系)研究科(研究院), 教授 (90252460)
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| Co-Investigator(Kenkyū-buntansha) |
AKATSUKA Shinya 名古屋大学, 医学系研究科, 講師 (40437223)
OKAZAKI Yasumasa 名古屋大学, 医学系研究科, 講師 (30403489)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 中皮腫 / アスベスト / 鉄 / マイクロアレイ解析 / 酸化ストレス / 予防 |
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| Outline of Final Research Achievements |
We analyzed the molecular carcinogenic mechanisms of mesothelioma by the use of rat model of intraperitoneal asbestos injection. This model revealed a very high incidence of mesothelioma with similar genetic alterations to human counterparts. We recognized that local iron overload is an important pathogenic factor, and showed a significant increase in epithelioid subtype that show favorable prognosis after preventive administration of an iron chelator, deferasirox. Furthermore, we identified connective tissue growth factor as a major responsible gene for sarcomatoid subtype and also for proliferation of mesothelioma cells.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013
Author(s)
S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
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Journal Title
Carcinogenesis
Volume: 35(1)
Issue: 1
Pages: 164-172
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Iron overload signature in chrysotile-induced malignant mesothelioma.2012
Author(s)
Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S.
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Journal Title
J Pathol
Volume: 228
Issue: 3
Pages: 366-77
DOI
Related Report
Peer Reviewed
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[Presentation] Iron, cancer and longevity.2013
Author(s)
Toyokuni S.
Organizer
Conference on healthy aging in Asia 2013. Strategy to meet health & lifestyle challenges.
Place of Presentation
Grand Copthorne Waterfront, Singapore ; invited speaker
Related Report
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[Presentation] Cancer as a ferrotoxic disease.2012
Author(s)
Toyokuni S.
Organizer
The 16^<th> Korea-Japan and the 2nd Korea-Taiwan-Japan Joint Conference for Gynecological Pathology
Place of Presentation
Kumamoto, Japan ; invited speaker
Year and Date
2012-05-26
Related Report
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[Presentation] Cancer as a ferrotixic disease.2012
Author(s)
Toyokuni S
Organizer
Free Radical and Metal Biology 20 12: Comined meeting of the Society for Free Radical Research Australasia and the Australian Biometals Group
Place of Presentation
Queensland Institute of Medical Research, Brisbane, Australia; invited speaker
Related Report
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