| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
We analyzed the molecular carcinogenic mechanisms of mesothelioma by the use of rat model of intraperitoneal asbestos injection. This model revealed a very high incidence of mesothelioma with similar genetic alterations to human counterparts. We recognized that local iron overload is an important pathogenic factor, and showed a significant increase in epithelioid subtype that show favorable prognosis after preventive administration of an iron chelator, deferasirox. Furthermore, we identified connective tissue growth factor as a major responsible gene for sarcomatoid subtype and also for proliferation of mesothelioma cells.
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