Escape mechanism from the extracellular stresses of apicomplexan parasites
| Project/Area Number |
24390103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
川原 史也 (財)日本生物科学研究所 (40390752)
アンドラビ ビラル 慶應義塾大学 (40468517)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | トキソプラズマ / プリマキン / マラリア / オルガネラ / 環境適応 |
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| Outline of Final Research Achievements |
Recently, the presence of an organelle, PLV/VAC, which forms only in extracellular environment and is important for the adaptation in it, was reported in Toxoplasma gondii. We identified this organelle independently and found it can classify three subcompartments.
We also found that one of the antimalarial drug, primaquine, releases H+ and Ca2+ from one of these three, PLV2, to the cytosol of T. gondii. We established primaquine-resistant T. gondii mutants and identified the responsible gene.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Seroprevalence of Toxoplasma gondii infection in cattle, horses, pigs and chickens in Japan2014
Author(s)
Matsuo, K., Kamai, R., Uetsu, H., Goto, H., Takashima, Y., and Nagamune, K.
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Journal Title
Parasitol. Int.
Volume: 63
Issue: 4
Pages: 638-639
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of a Tool for Evaluating the Risk of Health Damage by Meat-borne Parasite Infection2014
Author(s)
Yamasaki, H., Arakawa, K., Ohashi, T., Yagita, K., Morishima, Y., Sugiyama, H., Nagamune, K., Kakinuma, M., Osada, Y., Oushiki, D., Hasegawa, A.
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Journal Title
Food Safety
Volume: 2
Issue: 4
Pages: 151-159
DOI
NAID
ISSN
2187-8404
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of Eimeria brunetti isolated from a poultry farm in Japan2014
Author(s)
Kawahara, F., Zhang, G., Suzuki, T., Iwata, A., Nagamune, K., and Nunoya, T.
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Journal Title
J. Vet. Med. Sci.
Volume: 76
Pages: 25-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Gibberellin Biosynthetic Inhibitors Make Human Malaria Parasite Plasmodium falciparum Cells Swell and Rupture to Death2011
Author(s)
Toyama, T., Tahara, M., Nagamune, K., Arimitsu, K., Hamashim a, Y., Palacpac, N.M.Q., Kawaide, H., Horii, T., Tanabe, K.
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Journal Title
PLoS ONE
Volume: 7
Issue: 3
Pages: e32246-e32246
DOI
Related Report
Peer Reviewed
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[Presentation] The Acidic organelle in extracellular Toxoplasma gondii2013
Author(s)
Fkshi, M., Sakura, T., Tahara, M., Aonuma, H., Matsubara, R., Andrabi, S.B.A., and Nagamune, K.
Organizer
12th International Congress on Toxoplasmosis
Place of Presentation
Oxford, UK
Related Report
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[Presentation] Primaquine-resistance in Toxoplasma gondii is associated with the mutations in chloroquine resistance transporter (CRT), which are different from chloroquine resistance in Plasmodium falciparum.2013
Author(s)
Tahara, M., Fkshi, M., Sakura, T., Matsubara, R., Yamano, A., Yamagishi, J., and Nagamune, K.
Organizer
Molecular Parasitology Meeting XXIV
Place of Presentation
Woods Hole, MA, USA
Related Report
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[Presentation] The acidic organelle in extracellular Toxoplasma gondii2012
Author(s)
Fkshi, M., Aonuma, H., Matsubara, R., Tahara, M., Andrabi, S.B.A., and Nagamune, K.
Organizer
Molecular Parasitology Meeting XXIII
Place of Presentation
米国・ウッズホール、MA
Year and Date
2012-09-22
Related Report
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