|Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|Outline of Final Research Achievements
One third world human population is latently infected with, a major human pathogen, Mycobacterium tuberculosis. The eradication of persisting M. tuberculosis has been thought to be the most successful action against tuberculosis, because M. tuberculosis generally has no environmental or animal reservoirs. Although M. tuberculosis is a well adapted intracellular pathogen, we believe that maintaining latent state can prevent the disease. In order to realize it, knowing molecular mechanisms of latency and disease development is important. In this research we established the mouse latency and reactivation model utilizing M. tuberculosis 18b, of which growth is dependent on the presence of streptomycin. And we showed that artificial gene expression causes growth arrest of Mycobacterium. This may provide reasonable accommodation to prevent the disease progression by downshifting the M. tuberculosis growth in vivo.