| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
T-cell homeostasis preserves the numbers, the diversity and functional competence of different T cell subsets that are required for adaptive immunity. It is not clear how memory CD4+ T cell subsets are maintained in the periphery and what factors are responsible for the maintenance. To examine the homeostatic mechanisms, CFSE-labeled CD4+ effector memory T (TEM) cells were transferred into syngeneic C57BL/6 mice, and the systemic cell proliferative responses were assessed by CFSE dye dilution. We found that the fast homeostatic proliferation of TEM cells was strictly regulated by both antigen and OX40 costimulatory signals and that the slow proliferation was dependent on IL-7. The OX40-dependent fast proliferation preferentially expanded IL-17-producing helper T cells (Th17 cells). Together, both OX40 and IL-7 signals are required during homeostasis of TEM cells, and the synergistic signals may be critical for the expansion of Th17 cells.
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