Suppression mechanisms of autoimmune diseases by SATB1

• Project/Area Number: 24390121
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Toho University
• Principal Investigator: KONDO Motonari 東邦大学, 医学部, 教授 (20594344)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Fumio 東邦大学, 医学部, 講師 (10130345) ; TANAKA Yuriko 東邦大学, 医学部, 助教 (40396685)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 自己免疫疾患 / 免疫寛容 / Ｔ細胞 / ネガティブセレクション / 自己免疫

Outline of Final Research Achievements

Immune tolerance is maintained in the healthy condition; however, autoimmune diseases occur once immune tolerance is broken. We found that loss of a genome organiser, Special AT-rich binding protein-1 (SATB1), leads to autoimmune diseases in mice. In SATB1 deficient mice, negative selection, in which auto-reactive T cells are eliminated, is impaired. Therefore, SATB1 plays a critical role in establishment of immune tolerance.

Research Products

• [Journal Article] Thymic precursors of TCRab+CD8aa+ intraepithelial lymphocytes are negative for CD103 (2015)
  • Author(s): Xianghua Guo, Yuriko Tanaka, Motonari Kondo
  • Journal Title: Immuology Letters Volume: 163 Issue: 1 Pages: 40-48
  • DOI: 10.1016/j.imlet.2014.11.007
  • Peer Reviewed
• [Journal Article] An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development (2015)
  • Author(s): Bingtao Hao, Abani Kanta Naik , Akiko Watanabe , Hirokazu Tanaka , Liang Chen , Hunter W Richards, Motonari Kondo, Ichiro Taniuchi, Yoshinori Kohwi, Terumi Kohwi-Shigematsu, Michael S Krangel
  • Journal Title: Journal of experimental medicine Volume: 212 Issue: 5 Pages: 809-824
  • DOI: 10.1084/jem.20142207
  • Peer Reviewed
• [Journal Article] The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages. (2013)
  • Author(s): Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y.
  • Journal Title: Immunity Volume: 38 Issue: 6 Pages: 1105-1115
  • DOI: 10.1016/j.immuni.2013.05.014
  • Peer Reviewed
• [Journal Article] Y-chromosome-linked B- and NK-cell deficiency in mice (2013)
  • Author(s): Sun SL, Horino S, Itoh-Nakadai A, Kawabe T, Asao A, Takahashi T, So T, Funayama R, Kondo M, Saitsu H, Matumoto N, Nakayama K, and Ishii N
  • Journal Title: J. Immunol. Volume: 190 Issue: 12 Pages: 6209-6220
  • DOI: 10.4049/jimmunol.1300303
  • Peer Reviewed
• [Presentation] The function of SATB1 in a mouse model for sjogren's syndrome (2014)
  • Author(s): Yuriko Tanaka, Takehiko Sotome, Taku Kuwabra, Yasushi Akiba, Motonari Kondo
  • Organizer: 43rd,The annual meeting of the Japanese Society for Immunology
  • Place of Presentation: 国立京都国際会館 京都府 京都市
  • Year and Date: 2014-12-10
• [Presentation] SATB1 is required for development of experimental autoimmune encephalomyelitis (2014)
  • Author(s): Taku Kuwabara, Yasushi Akiba, Yuriko Tanaka, Taku Naito, Motonari Kondo
  • Organizer: 43rd,The annual meeting of the Japanese Society for Immunology
  • Place of Presentation: 国立京都国際会館 京都府 京都市
  • Year and Date: 2014-12-10
• [Presentation] 免疫寛容における分子制御機構の解析 (2014)
  • Author(s): 田中ゆり子, グオシャンファ, 向津隆規, 早乙女壮彦, 桑原卓, 近藤元就
  • Organizer: Kyoto T cell Conference 第24回学術集会
  • Place of Presentation: 京都平安ホテル 京都府 京都市
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] SATB1遺伝子欠損マウスにおける自己免疫疾患の病態解析 (2014)
  • Author(s): 早乙女壮彦, 渡邊美砂, 正田八州穂, 小峰由美子, 田中ゆり子, 郭向華, 近藤元就, 佐地勉
  • Organizer: 第26回 日本アレルギー学会春季臨床大会
  • Place of Presentation: 国立京都国際会館 京都府 京都市
  • Year and Date: 2014-05-09
• [Presentation] The role of SATB1 in mouse model of autoimmune disease. (2013)
  • Author(s): Mukozu T., Guo X., Tanaka Y., Ishikawa F., Kuwabara T., Kondo M.
  • Organizer: 第42回 日本免疫学会総会学術集会
  • Place of Presentation: 千葉県 千葉市 幕張メッセ
• [Presentation] SATB1 is necessary for IEL development. (2013)
  • Author(s): Guo x., Tanaka Y., Kondo M.
  • Organizer: 第42回 日本免疫学会総会学術集会
  • Place of Presentation: 千葉県 千葉市 幕張メッセ
• [Presentation] Acetylation modulates interleukin-2 receptor signaling. (2013)
  • Author(s): Kuwabara T., Kondo M.
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] SATB1 is necessary for establishment of the immune tolerance (2012)
  • Author(s): 田中 ゆり子
  • Organizer: 第41回 日本免疫学会総会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] Genome organizer SATB1 is critical for T cell maturation in the thymus
  • Author(s): Tanaka Y., Guo X., Mukozu T., Kuwabara T., Kondo M.
  • Organizer: 第42回 日本免疫学会総会学術集会
  • Place of Presentation: 千葉県 千葉市 幕張メッセ