• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The study of strategic therapy for inflammatory pulmonary diseases

Research Project

Project/Area Number 24390137
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionChiba University

Principal Investigator

KASUYA Yoshitoshi  千葉大学, 医学(系)研究科(研究院), 准教授 (70221877)

Co-Investigator(Kenkyū-buntansha) SUDO Tatsuhiko  理化学研究所, 基幹研, 専任研究員 (30260227)
SUGIYAMA Fumihiro  筑波大学, 人間総合科学研究科, 准教授 (90226481)
Co-Investigator(Renkei-kenkyūsha) TATSUMI Koichiro  千葉大学, 大学院医学研究院, 教授 (10207061)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords炎症性肺疾患 / 特発性肺線維症 / 慢性閉塞性肺疾患 / p38 / 肺胞上皮前駆細胞 / 細胞治療 / 線維化肺 / サイトカイン / ケモカイン / 炎症 / 肺疾患 / 遺伝子改変マウス / 幹・前駆細胞
Outline of Final Research Achievements

To propose new treatments for the inflammatory pulmonary diseases, the following studies were performed. (1) Reliability of anti-IL-6 strategy against pulmonary fibrosis was precisely evaluated. (2) We established a new experimental emphysema (COPD) mouse model. Transgenic (TG) mice expressing a p38-specific activator in the lung were subjected to our protocol, and plausible emphysema-associated molecules were comprehensively analyzed. (3) We have identified a new cell population having characteristics of lung-derived alveolar epithelial stem/progenitor cells and named it LMDEC. The engraftment of LMDECs was beneficial against lung fibrosis. (4) To expect the establishment of new inflammatory pulmonary disease mouse model, we tried to produce transgenic mice exhibiting p38 activation in drug-dependent and site (AECII)-specific manners.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (46 results)

All 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (30 results) (of which Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Trends in functions and inhibitors of p382015

    • Author(s)
      粕谷善俊
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 145 Issue: 1 Pages: 21-26

    • DOI

      10.1254/fpj.145.21

    • NAID

      130004827711

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of lung mixed culture-derived epithelial cells on lung fibrosis.2014

    • Author(s)
      Tanaka K, Fujita T, Umezawa H, Namiki K, Yoshioka K, Hagihara M, Sudo T, Kimura S, Tatsumi K, Kasuya Y.
    • Journal Title

      Lab Invest

      Volume: 94 Issue: 11 Pages: 1247-1259

    • DOI

      10.1038/labinvest.2014.109

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The second Tomoh Masaki award (2013)2014

    • Author(s)
      Emoto N, Kasuya Y, Yanagisawa M.
    • Journal Title

      Life Sci

      Volume: 118 Issue: 2 Pages: 87-90

    • DOI

      10.1016/j.lfs.2014.09.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p38 mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.2014

    • Author(s)
      Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y.
    • Journal Title

      J Recept Signal Transduc

      Volume: in press Issue: 4 Pages: 299-306

    • DOI

      10.3109/10799893.2014.896380

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin regulates function of IL-17-producing T cell subset.2014

    • Author(s)
      Tanaka K, Yoshioka K, Tatsumi K, Kimura S, Kasuya Y.
    • Journal Title

      Life Sci

      Volume: in press Issue: 2 Pages: 244-247

    • DOI

      10.1016/j.lfs.2014.01.084

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin B receptor-mediated encephalopathic events in mouce sepsis model.2014

    • Author(s)
      Naito Y, Yoshioka K, Tanaka K, Tatsumi K, Kimura S, Kasuya Y.
    • Journal Title

      Life Sci

      Volume: in press Issue: 2 Pages: 340-346

    • DOI

      10.1016/j.lfs.2014.03.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺組織共培養系由来の上皮細胞とその機能と応用2013

    • Author(s)
      田中健介,巽浩一郎,粕谷善俊
    • Journal Title

      日本肺サーファクタント・界面医学会雑誌

      Volume: 44 Pages: 18-19

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of CD69in acute lung injury2012

    • Author(s)
      Ishizaki S, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Yamauchi K, Matsunaga F, Iwamura C, Nakayama T Tatsumi K
    • Journal Title

      Life Sci

      Volume: Vol.90 Issue: 17-18 Pages: 657-665

    • DOI

      10.1016/j.lfs.2012.03.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism for p38a-mediated Experimental Autoimmune Encephalomyelitis2012

    • Author(s)
      Namiki, K., et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 24228-24238

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 成体海馬由来神経幹細胞の自己複製能・神経分化能におけるp38MAPキナーゼの役割2015

    • Author(s)
      吉岡健人,並木香奈,須藤龍彦,粕谷善俊
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 愛知県名古屋市熱田区
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 選択的ETBアンタゴニストによる敗血症モデルマウスの脳への効果2015

    • Author(s)
      内藤雄介,吉岡健人,巽浩一郎,粕谷善俊
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 愛知県名古屋市熱田区
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線維化肺に対して治療能力をもつ新たな肺胞上皮細胞集団2015

    • Author(s)
      梅澤弘毅,田中健介,藤田哲雄,吉岡健人,巽浩一郎,粕谷善俊
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 愛知県名古屋市熱田区
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] A role of p38 mitogen-activated protein kinase in emphysema induced by cigarette smoke solution and lipopolysaccharide in Mice.2014

    • Author(s)
      Amano H, Murata K, Matsunaga H, Tanaka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Kimura S, Tatsumi K, Kasuya Y.
    • Organizer
      American Thoracic Society (ATS) 2014 International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] A simple and low-invasive sepsis mouse model.2014

    • Author(s)
      Naito Y, Yoshioka Y, Tanaka K, Matsunaga H, Ishida J, Fukamizu A, Kimura S, Tatsumi K, Kasuya Y.
    • Organizer
      American Thoracic Society (ATS) 2014 International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of IL-6 signal in the epithelial injury-based mechanisms of lung fibrosis.2014

    • Author(s)
      Kobayashi T, Tanaka K, Amano H, Fujita T, Kimura S, Tatsumi K, Kasuya Y.
    • Organizer
      American Thoracic Society (ATS) 2014 International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intratracheal administration of ET receptor antagonists suppresses the development of LPS-induced acute lung injury.2014

    • Author(s)
      Fujita T, Tanaka K, Tatsumi K, Kimura S, Kasuya Y.
    • Organizer
      American Thoracic Society (ATS) 2014 International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] エンドセリンがIL-17産生T細胞の機能を制御する2014

    • Author(s)
      田中健介,吉岡健人,巽浩一郎,木村定雄,粕谷善俊あ
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-6シグナルの阻害はブレオマイシン誘導性肺障害を悪化させる2014

    • Author(s)
      小林健,田中健介,天野寛之,藤田哲雄,梅澤弘毅,木村定雄,巽浩一郎,粕谷善俊
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新たなCOPDモデルの提案とp38MAPKの関連について2014

    • Author(s)
      天野寛之,村田和弥,松永博文,田中健介,小林健,石田純治,深水昭吉,木村定雄,巽浩一郎,粕谷善俊
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性肺損傷におけるエンドセリン受容体拮抗薬の気管内投与による肺炎症の制御2014

    • Author(s)
      藤田哲雄,田中健介,巽浩一郎,木村定雄,粕谷善俊
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] The key phosphorylation signaling in type II alveolar epithelial cells under the development of pulmonary fibrosis2013

    • Author(s)
      小林健
    • Organizer
      第86回薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Improved method of pulmonary stem/progenitor cells isolation2013

    • Author(s)
      田中健介
    • Organizer
      第86回薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Consideration about a new mouse model of sepsis2013

    • Author(s)
      内藤雄介
    • Organizer
      第86回薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] p38阻害薬2013

    • Author(s)
      粕谷善俊
    • Organizer
      第57回日本リウマチ学会総会・学術集会/第22回国際リウマチシンポジウム
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新たな敗血症モデルマウスについての検討2013

    • Author(s)
      内藤雄介,吉岡健人,田中健介,松永博文,木村定雄,巽浩一郎,粕谷善俊
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺胞II型上皮細胞の新規調整法と応用2013

    • Author(s)
      田中健介,藤田哲雄,吉岡健人,木村定雄,巽浩一郎,粕谷善俊
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] II型肺胞上皮細胞とIL172013

    • Author(s)
      天野寛之,木村定雄,巽浩一郎,粕谷善俊
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺線維症の病態進展と蛋白質リン酸化シグナル2013

    • Author(s)
      小林健,田中健介,天野寛之,木村定雄,巽浩一郎,粕谷善俊
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intratracheal administration of endothelin receptor antagonists attenuates pulmonary inflammation in lipopolysaccharide-induced acute lung injury.2013

    • Author(s)
      Fujita T, Tanaka K, Tatsumi K, Kimura S, Kasuya Y.
    • Organizer
      The Thirteenth International Conference on Endothelin
    • Place of Presentation
      Tokyo Campus of Tsukuba University
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of selective ETB receptor antagonist on brain in sepsis mouse model.2013

    • Author(s)
      Naito Y, Tanaka K, Yoshioka K, Tatsumi K, Kimura S, Kasuya Y.
    • Organizer
      The Thirteenth International Conference on Endothelin
    • Place of Presentation
      Tokyo Campus of Tsukuba University
    • Related Report
      2013 Annual Research Report
  • [Presentation] Endothelin controls the IL-17 production from T lymphocytes.2013

    • Author(s)
      Tanaka K, Yoshioka K, Tatsumi K, Kimura S, Kasuya Y.
    • Organizer
      The Thirteenth International Conference on Endothelin
    • Place of Presentation
      Tokyo Campus of Tsukuba University
    • Related Report
      2013 Annual Research Report
  • [Presentation] p38によるIL-17遺伝子の転写制御様式2012

    • Author(s)
      吉岡健人
    • Organizer
      第126回薬理学会関東部会
    • Place of Presentation
      北里大学(白金)
    • Year and Date
      2012-07-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞治療に向けた、肺胞II型上皮細胞の簡便なin vitro expansion法の検討2012

    • Author(s)
      田中健介
    • Organizer
      第126回薬理学会関東部会
    • Place of Presentation
      北里大学(白金)
    • Year and Date
      2012-07-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] タバコ煙溶液およびリポポリサッカライドによるマウス肺気腫モデル2012

    • Author(s)
      天野寛之
    • Organizer
      第52回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸ポートピアホール
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス急性肺障害におけるCD69の役割2012

    • Author(s)
      石崎俊介
    • Organizer
      第52回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸ポートピアホール
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス急性喫煙暴露モデルにおけるCD69の役割2012

    • Author(s)
      露崎淳一
    • Organizer
      第52回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸ポートピアホール
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺胞II型上皮細胞の簡便なin vitro expansion法の検討2012

    • Author(s)
      田中健介
    • Organizer
      第52回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸ポートピアホール
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺線維症の病態進展と蛋白質リン酸化シグナル2012

    • Author(s)
      小林健
    • Organizer
      第52回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸ポートピアホール
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] ブレオマイシン肺線維症モデルマウスにおけるCD69の役割2012

    • Author(s)
      山内圭太
    • Organizer
      第52回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸ポートピアホール
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院分子生体制御学

    • URL

      http://www.m.chiba-u.ac.jp/class/bunsiseitai/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院分子生体制御学

    • URL

      http://www.m.chiba-u.ac.jp/class/bunsiseitai/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/bunsiseitai/index.html

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺障害治療能を有する細胞培養上清液2014

    • Inventor(s)
      萩原昌彦,粕谷善俊, 田中健介,藤田哲雄
    • Industrial Property Rights Holder
      萩原昌彦,粕谷善俊, 田中健介,藤田哲雄
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-24
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺サーファクタントタンパク質陽性細胞への分化誘導能を有する細胞培養上清液2014

    • Inventor(s)
      萩原昌彦,粕谷善俊, 田中健介,藤田哲雄
    • Industrial Property Rights Holder
      萩原昌彦,粕谷善俊, 田中健介,藤田哲雄
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-24
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 増大された継代能を有する神経幹細胞、前記増大された継代能を有する神経幹細胞の製造方法、神経幹細胞の継代能を増大させるための神経幹細胞の培養方法2013

    • Inventor(s)
      粕谷善俊,宮本憲優,尾野雄一,並木香奈
    • Industrial Property Rights Holder
      エーザイ・アール・アンド・ディー・マネジメント株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-29
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 増大された継代能を有する神経幹細胞、前記増大された継代能を有する神経幹細胞の製造方法、神経幹細胞の継代能を増大させるための神経幹細胞の培養方法2012

    • Inventor(s)
      粕谷善俊 宮本憲優 尾野雄一 並木香奈
    • Industrial Property Rights Holder
      エーザイ・アール・アンド・ティー・マネジメント株式会社
    • Industrial Property Number
      2012-241366
    • Filing Date
      2012-10-31
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi