| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
We conducted surveillance for mutations in the Plasmodium falciparum K13-propeller gene of an artemisinin-resistant candidate on 4 islands and one coastal village in Lake Victoria, Kenya with high transmission in 2012-2013. Four new types of nonsynonymous and five new types of synonymous mutations were detected among the 539 samples analyzed. All the mutations found were different from those reported in Cambodia and no mutations were observed at more than two of these five different sites. Furthermore, only one type of mutation, A578S, from the Mfangano Island was detected during two different seasons, whereas other mutations were not observed in the next season half a year later. Monitoring these molecular markers and the efficacy of antimalarial drugs is critical for increasing our understanding of artemisinin resistance and predicting their spread.
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