Area-specific human and parasite polymorphism in the context of global malaria eradication.
| Project/Area Number |
24390141
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka City University |
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Principal Investigator |
KANEKO AKIRA 大阪市立大学, 医学(系)研究科(研究院), 教授 (60169563)
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| Co-Investigator(Kenkyū-buntansha) |
TERAMOTO Isao (KIMATA Isao) 大阪市立大学, 医学(系)研究科(研究院), 講師 (20153174)
ISOZUMI Rie 大阪市立大学, 医学(系)研究科(研究院), 講師 (30550355)
HIRATSUKA Masahiro 東北大学, 薬学研究科(研究院), 准教授 (50282140)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | マラリア撲滅 / 熱帯熱マラリア / アルテミシニン / G6PD欠損症 / 原虫薬剤耐性 / ケニア / オセアニア / 薬剤耐性 / 熱帯熱マラリア原虫 / プリマキン / 集団治療 / 血管内溶血 / 島嶼マラリア / ビクトリア湖 / マラリア / チトクロームP450 / 熱帯アフリカ |
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| Outline of Final Research Achievements |
We conducted surveillance for mutations in the Plasmodium falciparum K13-propeller gene of an artemisinin-resistant candidate on 4 islands and one coastal village in Lake Victoria, Kenya with high transmission in 2012-2013. Four new types of nonsynonymous and five new types of synonymous mutations were detected among the 539 samples analyzed. All the mutations found were different from those reported in Cambodia and no mutations were observed at more than two of these five different sites. Furthermore, only one type of mutation, A578S, from the Mfangano Island was detected during two different seasons, whereas other mutations were not observed in the next season half a year later. Monitoring these molecular markers and the efficacy of antimalarial drugs is critical for increasing our understanding of artemisinin resistance and predicting their spread.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization2015
Author(s)
Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M, Tsuboi T
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Journal Title
Vaccine
Volume: 33
Issue: 16
Pages: 1901-1908
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms.2014
Author(s)
JovelIT, Ferreira PE, Veiga MI, Malmberg M, Mårtensson A, Kaneko A, Zakeri S, Murillo C, Nosten F, Björkman A, Ursing J.
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Journal Title
Infect Genet Evol.
Volume: in press
Pages: 111-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Behavioral risk factors for obesity during health transition in Vanuatu, South Pacific2013
Author(s)
Dancause KN, Vilar M, Wilson M, Soloway LE, DeHuff C, Chan C, Tarivonda L, Regenvanu R, Kaneko A, Lum JK, Garruto RM
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Journal Title
Obesity (Silver Spring)
Volume: 21
Issue: 1
DOI
Related Report
Peer Reviewed
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[Journal Article] Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt2012
Author(s)
Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, Sattabongkot J, Nakamura M, Sakurai M, Kobayashi J, Kaneko A, Endo H, Hombhanje F, Tsuboi T, Mita T
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Journal Title
Malaria Journal
Volume: 11
Issue: 1
Pages: 92-92
DOI
NAID
Related Report
Peer Reviewed
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