Exploratory Research for Fetal Programming Effects by Using Omics Analysis including Epigenomics
| Project/Area Number |
24390144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | グライコミクス / グリコブロッティング / 胎児プログラミング / 低出生体重児 / 不当軽量児 / N-グリカン / 予知医学 / エピゲノミクス / 予防医学 / 極低出生体重児 / グライコブロッティング法 / オミックス |
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| Outline of Final Research Achievements |
To investigate which cord blood N-glycans are associated with poor fetal environment indicators including LBW and SGA, or rapid weight gain in early infancy. From a regional prospective birth cohort, 36 LBW neonates and 120 normal-birth-weight neonates were recruited. A comprehensive glycoblotting using MALDI-TOF-MS-based N-glycan analysis in cord blood from these neonates were conducted. A total of 35 N-glycans were detected (m/z 1362.481-3865.407). Of these, G3414 were correlated with both LBW and SGA in logistic regression. G1915, G2744, G3049 and G3719 were associated with LBW. In the prospective follow-up analysis, these 5 N-glycans were all associated with 6 and 18-months rapid weight gain after birth. These identified candidate N-glycans are structurally categorized into two different categories. These N-glycans were suggestive of potential predictors of poor fetal environment or rapid weight gain after birth.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Recommended use of Cut-off Folate Concentration in Serum and Erythrocyte(Red Blood Cell) as Expressed by Folic Acid Equivalent for the Diagnosis of Deficiency in Deliberating the Creation on Dietary Reference Intakes.2015
Author(s)
Ihara H, Hirota K, Watanabe T, Totani M, Hashizume N, Aoki Y, Nagashima Y, Kamioka K, Onda K, Sunahara S, Suzuki T, Itabashi M, Ishibashi M, Ito S, Ohashi K, Ohta Y, Nobori T, Fujishiro K, Maekawa M, Miura M, Miyano H, Ando T, Nishimura K
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Journal Title
Austin J Nutri Food Sci
Volume: 3(1)
Pages: 1055-1056
Related Report
Peer Reviewed / Open Access
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[Journal Article] National Institute of Standards and Technorogy SRM 972 as a reference material for serum total 25-hydroxyvitamin D measurements.2014
Author(s)
Ihara H, Hirota K, Miura M, Kitajima I, Yamashita M, Nomura F, Nishimura M, Totani M, Hashizume N,Aoki Y, Nagashima Y, Kamioka K, Onda K, Sunahara S, Suzuki T, Itabashi M, Ishibashi M, Ito S, Ohashi K, Ohta Y, Nobori T, Fujishiro K, Maekawa M, Miyano H, Ando T, Nishimura K, Tsugawa N, Okano T :
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Journal Title
Int Anal Bio-Sci
Volume: 2 (1)
Pages: 1-6
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasma connective tissue growth factor levels as potential biomarkers of airway obstruction in patients with asthma. Ann Allergy Asthma Immunol.2014
Author(s)
Kato M, Fujisawa T, Hashimoto D, Kono M, Enomoto N, Nakamura Y, Inui N, Hamada E, Miyazaki O, Kurashita S, Maekawa M, Suda T
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Journal Title
Ann Allergy Asthma Immunol.
Volume: 113 (3)
Issue: 3
Pages: 295-300
DOI
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Peer Reviewed / Open Access
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[Journal Article] IgG4-related skin disease.2014
Author(s)
Tokura Y, Yagi H, Yanaguchi H, Majima Y, Kasuya A, Ito T, Maekawa M, Hashizume H
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Journal Title
Br J Dermatol.
Volume: 171
Issue: 5
Pages: 959-967
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TLR-Mediated Airway IL-17C Enhances Epithelial Host Defense in an Autocrine/Paracrine Manner.2014
Author(s)
Kusagaya H, Fujisawa T*, Yamanaka K, Mori K, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Wu R, Maekawa M, Suda T, Chida K.
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Journal Title
Am J Respir Cell Mol Biol.
Volume: 50
Issue: 1
Pages: 30-39
DOI
Related Report
Peer Reviewed
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[Journal Article] A sudden onset and the spontaneous remission of severe hypo-high-density lipoprotein cholesterolemia without serious underlying disease: a case report.2013
Author(s)
Ohba K, Oki Y, Fujita K, Kameko F, Moriyama T, Horiike Y, Morita H, Matsushita A, Iino K, Sasaki S, Nakamura H, Maekawa M.
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Journal Title
Clin Chim Acta.
Volume: 15
Pages: 91-94
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[Journal Article] Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues.2013
Author(s)
Kosanam H, Prassas I, Chrystoja CC, Soleas I, Chan A, Dimitromanolakis A, Blasutig IM, Rückert F, Gruetzmann R, Pilarsky C, Maekawa M, Brand R, Diamandis EP
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Journal Title
Mol Cell Proteomics
Volume: 12(10)
Issue: 10
Pages: 2820-2832
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum levels of soluble platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 are decreased in subjects with autism spectrum disorder.2013
Author(s)
Kameno Y, Iwata K, Matsuzaki H, Miyachi T, Tsuchiya KJ, Matsumoto K, Iwata Y, Suzuki K, Nakamura K, Maekawa M, Tsujii M, Sugiyama T, Mori N.
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Journal Title
Mol Autism
Volume: 4
Issue: 1
Pages: 19-19
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[Journal Article] Hepatocellular adenoma associated with familial adenomatous polyposis coli.2012
Author(s)
Inaba K, Sakaguchi T, Kurachi K, Mori H, Tao, H, Nakamura T, Takehara Y, Baba S, Maekawa M, Sugimura H, Konno H
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Journal Title
World Journal of Hepatology
Volume: 4(11)
Issue: 11
Pages: 322-326
DOI
Related Report
Peer Reviewed
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