Development of integrated molecular pathological diagnostic systems for cancer
Project/Area Number |
24390145
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
DAIGO YATARO 滋賀医科大学, 医学部, 教授 (30345029)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 分子病態診断 / バイオマーカー |
Outline of Final Research Achievements |
Cancer is one of the most serious diseases which has a notably poor prognosis, and its incidence is annually increasing in Japan and worldwide. The number of patients responding well to current standard cancer therapies is still small, and no diagnostic marker has been sufficiently useful in the detection of curative stage cancers. In this study, we identified various cancer-related molecules, which are being applied as new diagnostic biomarkers. These biomarkers could be useful for early cancer detection, monitoring, and for the choice of therapies, as well as being a suitable therapeutic target.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.2015
Author(s)
Kusakabe K, Ide N, Daigo Y, Itoh T, Yamamoto T, Hashizume H, Nozu K, Yoshida H, Tadano G, Tagashira S, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Ando S, Maeda M, Higaki M, Baba Y, Nakamura Y
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Journal Title
J Med Chem
Volume: 58
Issue: 4
Pages: 1760-1775
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease.2014
Author(s)
Tomita Y, Yuno A, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Imamura Y, Yatsuda J, Sayem MA, Irie A, Hamada A, Jono H, Yoshida K, Tsunoda T, Daigo Y, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological features and EGFR gene mutation status in elderly patients with resected non-small-cell lung cancer.2014
Author(s)
Nishii T, Yokose T, Miyagi Y, Daigo Y, Ito H, Isaka T, Imai K, Murakami S, Kondo T, Saito H, Oshita F, Yamada K, Matsukuma S, Tsuboi M, Nakayama H, Masuda M
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Journal Title
BMC Cancer
Volume: 14
Issue: 1
Pages: 610-610
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.2013
Author(s)
Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
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Journal Title
Mol Cancer Res
Volume: 11
Issue: 8
Pages: 937-951
DOI
Related Report
Peer Reviewed
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[Journal Article] Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions.2013
Author(s)
Kamada Y, Kinoshita N, Tsuchiya Y, Kobayashi K, Fujii H, Terao N, Kamihagi K, Koyama N, Yamada S, Daigo Y, Nakamura Y, Taniguchi N, Miyoshi E.
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Journal Title
Clin Chim Acta
Volume: 417
Pages: 48-53
DOI
Related Report
Peer Reviewed
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[Journal Article] Indazole-based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125).2013
Author(s)
Kusakabe K, Ide N, Daigo Y, Tachibana Y, Itoh T, Yamamoto T, Hashizume H, Hato Y, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Yasuo K, Maeda M, Higaki M, Ueda K, Yoshizawa H, Baba Y, Shiota T, Murai H, Nakamura Y.
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Journal Title
J Med Chem
Volume: 56
Issue: 11
Pages: 4343-4356
DOI
Related Report
Peer Reviewed
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[Journal Article] Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.2013
Author(s)
Kogure M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, Kobayashi T, Daigo Y, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.
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Journal Title
Cancer Letters
Volume: 336
Issue: 1
Pages: 76-84
DOI
Related Report
Peer Reviewed
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[Journal Article] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population2012
Author(s)
Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
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Journal Title
Nature Genetics
Volume: 44
Issue: 8
Pages: 900-903
DOI
Related Report
Peer Reviewed
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[Journal Article] Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of aurora kinase B2012
Author(s)
Hyun-Soo Cho, Shinya Hayami, Gouji Toyokawa, Kazuhiro Maejima, Yuka Yamane, Takehiro Suzuki, Naoshi Dohmae, Masaharu Kogure, Daechun Kang, David E, Neal, Bruce, A. J. Ponder, Hiroki Yamaue, Yusuke Nakamura, Ryuji Hamamoto
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Journal Title
Nature Communications
Volume: 3
Issue: 1
Pages: 1072-1072
DOI
Related Report
Peer Reviewed
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[Book] 呼吸2013
Author(s)
醍醐弥太郎
Total Pages
106
Publisher
呼吸研究
Related Report
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[Book] 日本臨床2012
Author(s)
醍醐弥太郎
Total Pages
180
Publisher
日本臨床社
Related Report