Development of integrated molecular pathological diagnostic systems for cancer

• Project/Area Number: 24390145
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: DAIGO YATARO 滋賀医科大学, 医学部, 教授 (30345029)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 分子病態診断 / バイオマーカー

Outline of Final Research Achievements

Cancer is one of the most serious diseases which has a notably poor prognosis, and its incidence is annually increasing in Japan and worldwide. The number of patients responding well to current standard cancer therapies is still small, and no diagnostic marker has been sufficiently useful in the detection of curative stage cancers. In this study, we identified various cancer-related molecules, which are being applied as new diagnostic biomarkers. These biomarkers could be useful for early cancer detection, monitoring, and for the choice of therapies, as well as being a suitable therapeutic target.

Research Products

• [Journal Article] Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity. (2015)
  • Author(s): Kusakabe K, Ide N, Daigo Y, Itoh T, Yamamoto T, Hashizume H, Nozu K, Yoshida H, Tadano G, Tagashira S, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Ando S, Maeda M, Higaki M, Baba Y, Nakamura Y
  • Journal Title: J Med Chem Volume: 58 Issue: 4 Pages: 1760-1775
  • DOI: 10.1021/jm501599u
  • Peer Reviewed
• [Journal Article] Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine. (2015)
  • Author(s): Ohshio Y, Teramoto K, Hanaoka J, Tezuka N, Itoh Y, Asai T, Daigo Y, Ogasawara K
  • Journal Title: Cancer Sci Volume: 106 Issue: 2 Pages: 134-142
  • DOI: 10.1111/cas.12584
  • Peer Reviewed / Open Access
• [Journal Article] Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease. (2014)
  • Author(s): Tomita Y, Yuno A, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Imamura Y, Yatsuda J, Sayem MA, Irie A, Hamada A, Jono H, Yoshida K, Tsunoda T, Daigo Y, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y
  • Journal Title: Oncoimmunology Volume: 3
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological features and EGFR gene mutation status in elderly patients with resected non-small-cell lung cancer. (2014)
  • Author(s): Nishii T, Yokose T, Miyagi Y, Daigo Y, Ito H, Isaka T, Imai K, Murakami S, Kondo T, Saito H, Oshita F, Yamada K, Matsukuma S, Tsuboi M, Nakayama H, Masuda M
  • Journal Title: BMC Cancer Volume: 14 Issue: 1 Pages: 610-610
  • DOI: 10.1186/1471-2407-14-610
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis (2014)
  • Author(s): T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura
  • Journal Title: International journal of oncology Volume: 45(1) Issue: 1 Pages: 147-56
  • DOI: 10.3892/ijo.2014.2418
  • Peer Reviewed / Open Access
• [Journal Article] A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses. (2013)
  • Author(s): Daigo Y, Takano A, Teramoto K, Chung S, Nakamura Y.
  • Journal Title: Clin Pharmacol Ther Volume: 94 Issue: 2 Pages: 218-223
  • DOI: 10.1038/clpt.2013.90
  • Peer Reviewed
• [Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. (2013)
  • Author(s): Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
  • Journal Title: Mol Cancer Res Volume: 11 Issue: 8 Pages: 937-951
  • DOI: 10.1158/1541-7786.mcr-12-0685-t
  • Peer Reviewed
• [Journal Article] Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions. (2013)
  • Author(s): Kamada Y, Kinoshita N, Tsuchiya Y, Kobayashi K, Fujii H, Terao N, Kamihagi K, Koyama N, Yamada S, Daigo Y, Nakamura Y, Taniguchi N, Miyoshi E.
  • Journal Title: Clin Chim Acta Volume: 417 Pages: 48-53
  • DOI: 10.1016/j.cca.2012.12.014
  • Peer Reviewed
• [Journal Article] Indazole-based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). (2013)
  • Author(s): Kusakabe K, Ide N, Daigo Y, Tachibana Y, Itoh T, Yamamoto T, Hashizume H, Hato Y, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Yasuo K, Maeda M, Higaki M, Ueda K, Yoshizawa H, Baba Y, Shiota T, Murai H, Nakamura Y.
  • Journal Title: J Med Chem Volume: 56 Issue: 11 Pages: 4343-4356
  • DOI: 10.1021/jm4000215
  • Peer Reviewed
• [Journal Article] Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition. (2013)
  • Author(s): Kogure M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, Kobayashi T, Daigo Y, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.
  • Journal Title: Cancer Letters Volume: 336 Issue: 1 Pages: 76-84
  • DOI: 10.1016/j.canlet.2013.04.009
  • Peer Reviewed
• [Journal Article] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population (2012)
  • Author(s): Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
  • Journal Title: Nature Genetics Volume: 44 Issue: 8 Pages: 900-903
  • DOI: 10.1038/ng.2353
  • Peer Reviewed
• [Journal Article] Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of aurora kinase B (2012)
  • Author(s): Hyun-Soo Cho, Shinya Hayami, Gouji Toyokawa, Kazuhiro Maejima, Yuka Yamane, Takehiro Suzuki, Naoshi Dohmae, Masaharu Kogure, Daechun Kang, David E, Neal, Bruce, A. J. Ponder, Hiroki Yamaue, Yusuke Nakamura, Ryuji Hamamoto
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1072-1072
  • DOI: 10.1038/ncomms2074
  • Peer Reviewed
• [Journal Article] Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis (2012)
  • Author(s): T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura
  • Journal Title: Cancer research Volume: 72(16) Issue: 16 Pages: 4110-8
  • DOI: 10.1158/0008-5472.can-12-0159
  • Peer Reviewed
• [Journal Article] Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis (2012)
  • Author(s): M. H. Nguyen, K. Ueda, Y. Nakamura, and Y. Daigo
  • Journal Title: International journal of oncology Volume: 41(4) Issue: 4 Pages: 1285-96
  • DOI: 10.3892/ijo.2012.1589
  • Peer Reviewed
• [Presentation] Characterization of Serine/Threonine phosphatase LAPP1 as a diagnostic and therapeutic target for lung cancer. (2014)
  • Author(s): Daigo Y, Nakamura Y
  • Organizer: The 11th International Conference on Protein Phosphatase
  • Place of Presentation: 東北大学艮陵会館（宮城県）
  • Year and Date: 2014-11-12 – 2014-11-14
  • Invited
• [Presentation] セリン・スレオニンフォスファターゼLAPP1の肺発がんにおける機能解析と診断・治療への応用 (2014)
  • Author(s): 醍醐弥太郎、中村祐輔
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館（京都府）
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] Recent advances of cancer immunotherapy and future prospects towards personalized medicine. (2014)
  • Author(s): Daigo Y
  • Organizer: 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] Development of therapeutic cancer vaccine for lung cancer. (2014)
  • Author(s): Daigo Y, Nakamura Y
  • Organizer: 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] Cancer Genomics-based Approach for Development of New Immunotherapeutics for Lung Cancers. (2014)
  • Author(s): Daigo Y, Takano A, Teramoto K, Nakamura Y
  • Organizer: 2014 ASCO Annual Meeting
  • Place of Presentation: MacCormick Place Convention Center (Chicago, USA）
  • Year and Date: 2014-05-29 – 2014-06-02
• [Presentation] Ras and EF-hand domain containing as a novel tissue biomarker and a therapeutic target for lung cancer. (2014)
  • Author(s): Daigo Y, Takano A, Nakamura Y
  • Organizer: 2014 AACR Annual Meeting
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Epstein-Barr Virus-induced gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer. (2013)
  • Author(s): Daigo Y, Takano A, Nakamura Y
  • Organizer: 2013 AACR Annual Meeting
  • Place of Presentation: Walter E. Washington Convention Center (Washington, DC, USA)
• [Presentation] Systematic approach for development of new immunotherapeutics for lung cancers through cancer genomics analysis. (2013)
  • Author(s): Daigo Y, Takano A, Nakamura Y
  • Organizer: 2013 ASCO Annual Meeting
  • Place of Presentation: McCormick Place Convention Center (Chicago, USA)
• [Presentation] Development of therapeutic cancer peptide vaccines for lung cancer. (2013)
  • Author(s): Daigo Y, Nakamura Y
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台国際センター (宮城県）
  • Invited
• [Presentation] Development of new cancer peptide vaccine therapy against lung cancer. (2013)
  • Author(s): Daigo Y, Nakamura Y
  • Organizer: 72th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜 (神奈川県）
  • Invited
• [Presentation] がんの分子病態研究に基づいた個別化医療開発 (2013)
  • Author(s): 醍醐弥太郎
  • Organizer: 第761回千葉県がんセンター研究所集談会
  • Place of Presentation: 千葉県がんセンター （千葉県）
  • Invited
• [Presentation] Development of new cancer vaccine therapy against lung cancer (2012)
  • Author(s): Yataro Daigo
  • Organizer: 第10回日本臨床腫瘍学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)(招待講演)
  • Year and Date: 2012-07-26
• [Presentation] Genome-wide association study of lung cancer : Variation in TP63 gene confers the risk of lung adenocarcinoma (2012)
  • Author(s): Yataro Daigo, Daiki Miki, Yusuke Nakamura
  • Organizer: 103th AACR Annual meeting
  • Place of Presentation: McCormick Place Convention Center (Chicago, USA)
  • Year and Date: 2012-04-02
• [Book] BioClinica (2015)
  • Author(s): 醍醐弥太郎
  • Total Pages: 87
  • Publisher: 北隆館
• [Book] 呼吸器内科 (2014)
  • Author(s): 醍醐弥太郎
  • Total Pages: 74
  • Publisher: 科学評論社
• [Book] 雑誌 腫瘍内科 (2014)
  • Author(s): 醍醐弥太郎
  • Total Pages: 161
  • Publisher: 科学評論社
• [Book] 呼吸 (2013)
  • Author(s): 醍醐弥太郎
  • Total Pages: 106
  • Publisher: 呼吸研究
• [Book] WWaves (2013)
  • Author(s): 醍醐弥太郎
  • Total Pages: 94
  • Publisher: 日本癌病態治療研究会
• [Book] 薬学雑誌ファルマシア (2013)
  • Author(s): 醍醐弥太郎
  • Total Pages: 98
  • Publisher: 日本薬学会
• [Book] 日本臨床 (2012)
  • Author(s): 醍醐弥太郎
  • Total Pages: 180
  • Publisher: 日本臨床社