| Project/Area Number |
24390148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | University of Fukui |
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Principal Investigator |
MURASE Kazuyuki 福井大学, 工学(系)研究科(研究院), 教授 (40174289)
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| Co-Investigator(Kenkyū-buntansha) |
FURUE Hideaki 生理学研究所, 神経シグナル研究部門, 准教授 (20304884)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Hiroshi 福井大学, 大学院工学研究科, 教授 (80377473)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | in vivo多細胞記録 / カルシウムイメージング / 共焦点レーザー顕微鏡 / 痛覚 / 慢性疼痛 / 脳・神経 / 可視化 / 神経科学 / 共焦点顕微鏡 / 生体生命情報科学 / 生体生命情報学 / 生物・生体工学 / 疼痛 |
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| Outline of Final Research Achievements |
For the induction of hyperalgesia and chronic pain, glial cells, in addition to neuronal plasticity in the spinal cord and brain, plays an important role. However, pain appears in different pathologies, and it is quite unclear how pain is expressed by excitation patterns in neurons and glial cells in the spinal cord and brain. In this study, we tried to record excitation of multiple cells simultaneously in the spinal cord and the brain in vitro and in vivo by using a Nipkow disk confocal laser microscope, and to clarify how pain such as hyperalgesia is expressed in the cellular activities.
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