| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Pain in cancer is often associated with tumor compression or infiltration on tissues. Cancer-related neuropathic pain also arises from injury attributable to infiltration of malignant cells into peripheral nerves. One troublesome hallmark symptom of neuropathic pain is hypersensitivity to normally innocuous stimuli, a condition known as “tactile allodynia” that is refractory even to opioids. The intensity of neuropathic pain in patients with cancer has been known to vary over 24 hour. We aimed to clarify the molecular link connecting the circadian clock to neuropathic pain, and identified a molecule responsible for causing the circadian variation of “allodynia”. Importantly, suppressing the function of the circadian-allodynic molecule resulted in the significant attenuation of neuropathic pain. Identification of mechanism underlying the circadian change in the pathological condition will be useful strategy to discover new therapeutic target.
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