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MicroRNA-based risk assessment for fibrous and particulate substances on the basis of molecular epidemiological and experimental studies

Research Project

Project/Area Number 24390153
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

HIRAKU Yusuke  三重大学, 医学(系)研究科(研究院), 講師 (30324510)

Co-Investigator(Kenkyū-buntansha) OMAE Kazuyuki  慶應義塾大学, 医学部, 教授 (60118924)
TANAKA Akiyo  九州大学, 医学研究院, 講師 (10136484)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords繊維・粒子状物質 / マイクロRNA / インジウム / 石綿 / 発がん / リスク評価 / 線維化 / カーボンナノチューブ / 分子疫学 / シリカ
Outline of Final Research Achievements

Inhalation exposure to fibrous and particlate materials induces carcinogenesis and fibrosis in respiratory systems, but precise mechanisms remain to be clarified. We have performed comprehensive microarray analysis for microRNA (miRNA) and gene expression in the lung tissues of animals exposed to asbestos and indium compounds. We found that these compounds significanlty changed the expression levels of several miRNAs, which may regulate genes involved in carcinogenesis and fibrosis. We also found that an indium compound altered miRNA levels in the serum of rats. These findings raise the possibility that miRNAs can be used for evaluation of the risk of respiratory diseases in individuals exposed to these compounds and provide an insight into molecular epidemiology for indium-exposed workers.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (56 results)

All 2015 2014 2013 2012 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Acknowledgement Compliant: 7 results,  Open Access: 5 results) Presentation (32 results) (of which Invited: 1 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway2015

    • Author(s)
      Laothong U, Hiraku Y, Oikawa S, Intuyod K, Murata M, Pinlaor S.
    • Journal Title

      Oncol Rep

      Volume: 33 Issue: 3 Pages: 1443-1449

    • DOI

      10.3892/or.2015.3738

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Formation of the Nitrative DNA Lesion 8-Nitroguanine is Associated with Asbestos Contents in Human Lung Tissues: A Pilot Study2014

    • Author(s)
      Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga N, Ma N, Kawanishi S, Murata M
    • Journal Title

      Journal of Occupational Health

      Volume: 56 Issue: 3 Pages: 186-196

    • DOI

      10.1539/joh.13-0231-OA

    • NAID

      130004447649

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metal-mediated oxidative DNA damage induced by methylene blue2014

    • Author(s)
      Hiraku Y, Goto H, Kohno M, Kawanishi S, Murata M
    • Journal Title

      Biochim Biophys Acta

      Volume: 1840 Issue: 9 Pages: 2776-2782

    • DOI

      10.1016/j.bbagen.2014.04.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Five-year cohort study: emphysematous progression of indium-exposed workers.2014

    • Author(s)
      Nakano M, Omae K, Uchida K, Michikawa T, Yoshioka N, Hirata M, Tanaka A
    • Journal Title

      Chest

      Volume: 146 Issue: 5 Pages: 1166-1175

    • DOI

      10.1378/chest.13-2484

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationships of alpha-SMA-positive fibroblasts and SDF-1-positive tumor cells with neoangiogenesis in nasopharyngeal carcinoma2014

    • Author(s)
      Wang S, Ma N, Kawanishi S, Hiraku Y, Oikawa S, Xie Y, Zhang Z, Huang G, Murata M
    • Journal Title

      Biomed Res Int

      Volume: 2014 Pages: 507353-507353

    • DOI

      10.1155/2014/507353

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oxidative stress and its significant roles in neurodegenerative diseases and cancer.2014

    • Author(s)
      Thanan R, Oikawa S, Hiraku Y, Ohnishi S, Ma N, Pinlaor S, Yongvanit P, Kawanishi S, Murata M
    • Journal Title

      Int J Mol Sci

      Volume: 16 Issue: 1 Pages: 193-217

    • DOI

      10.3390/ijms16010193

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 環境因子による酸化・ニトロ化DNA損傷と発がんリスク評価2014

    • Author(s)
      平工雄介
    • Journal Title

      福岡医学雑誌

      Volume: 105 Pages: 33-41

    • NAID

      120005438022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis2013

    • Author(s)
      Thanan R, Pairojkul C, Pinlaor S, Khuntikeo N, Wongkham C, Sripa B, Ma N, Vaeteewoottacharn K, Furukawa A, Kobayashi H, Hiraku Y, Oikawa S, Kawanishi S, Yongvanit P, Murata M
    • Journal Title

      Free Radic Biol Med

      Volume: 65 Pages: 1464-1472

    • DOI

      10.1016/j.freeradbiomed.2013.07.034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol and lipid profiles in plasma and the expression of α-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters2013

    • Author(s)
      Laothong U
    • Journal Title

      Parasitol Int

      Volume: 62 Issue: 2 Pages: 127-133

    • DOI

      10.1016/j.parint.2012.11.002

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells2012

    • Author(s)
      Guo, F.
    • Journal Title

      Toxicol.Appl.Pharmacol.

      Volume: (印刷中) Issue: 2 Pages: 183-192

    • DOI

      10.1016/j.taap.2012.02.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.2012

    • Author(s)
      Mo Y
    • Journal Title

      Cancer Lett

      Volume: 323 Issue: 2 Pages: 147-154

    • DOI

      10.1016/j.canlet.2012.03.042

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma2012

    • Author(s)
      Thanan, R.
    • Journal Title

      Free Radic.Biol.Med.

      Volume: (印刷中) Issue: 8 Pages: 1465-1472

    • DOI

      10.1016/j.freeradbiomed.2012.01.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer2012

    • Author(s)
      Thanan R, Murata M, Ma N, Hammam O, Wishahi M, El Leithy T, Hiraku Y, Oikawa S, Kawanishi S
    • Journal Title

      Mediators Inflamm

      Volume: 2012 Pages: 165879-165879

    • DOI

      10.1155/2012/165879

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.2012

    • Author(s)
      Thanan R
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 421 Issue: 2 Pages: 280-285

    • DOI

      10.1016/j.bbrc.2012.03.152

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma2012

    • Author(s)
      Prakobwong, S.
    • Journal Title

      Int.J.Cancer

      Volume: (印刷中) Issue: 4

    • DOI

      10.1002/ijc.26443

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The liver fluke Opisthorchis viverrini expresses nitric oxide synthase but not gelatinases2012

    • Author(s)
      Prakobwong, S.
    • Journal Title

      Parasitol.Int.

      Volume: 61 Issue: 1 Pages: 112-117

    • DOI

      10.1016/j.parint.2011.06.017

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma2012

    • Author(s)
      Rucksaken R
    • Journal Title

      Cancer Biomark

      Volume: 12 Issue: 2 Pages: 81-95

    • DOI

      10.3233/cbm-130296

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 多層カーボンナノチューブによる細胞内ニトロ化DNA損傷:Toll様受容体の関与2015

    • Author(s)
      平工雄介、山田達彦、馬寧、川西正祐、村田真理子
    • Organizer
      第85回日本衛生学会総会
    • Place of Presentation
      和歌山県民文化会館・ホテルアバローム紀の国、和歌山市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多層カーボンナノチューブによるニトロ化DNA損傷とToll様受容体の役割2015

    • Author(s)
      平工雄介、山田達彦、馬寧、川西正祐、村田真理子
    • Organizer
      第14回分子予防環境医学研究会
    • Place of Presentation
      大阪市立大学、大阪市
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多層カーボンナノチューブによる細胞内DNA損傷の解析(第3報): リソソーム内Toll様受容体の役割2014

    • Author(s)
      平工雄介、山田達彦、馬寧、村田真理子
    • Organizer
      日本産業衛生学会東海地方会
    • Place of Presentation
      三重大学、津市
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] アスベスト曝露マウスの肺組織におけるマイクロRNA発現の解析(第2報): 発がんへの関与の可能性2014

    • Author(s)
      渡辺純、金子晟、市瀬孝道、村田真理子、平工雄介
    • Organizer
      日本産業衛生学会東海地方会
    • Place of Presentation
      三重大学、津市
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Alteration in miRNA expression in the lung of asbestos-exposed mice (アスベスト曝露マウスの肺組織におけるマイクロRNAの発現変動)2014

    • Author(s)
      平工雄介、市瀬孝道、村田真理子
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] アスベスト気管内投与マウスの肺組織におけるマイクロRNA発現の解析2014

    • Author(s)
      平工雄介、市瀬孝道、村田真理子
    • Organizer
      第84回日本衛生学会総会
    • Place of Presentation
      岡山コンベンションセンター、岡山市
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト肺組織におけるニトロ化DNA損傷と石綿繊維量の関連および繊維長の影響2014

    • Author(s)
      平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター・岡山シティミュージアム、岡山市、
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナノ素材のリスク評価に関する基礎的研究(第3報):多層カーボンナノチューブによる細胞内ニトロ化DNA損傷の解析2013

    • Author(s)
      平工雄介、村田真理子
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      ひめぎんホール(愛媛県県民文化会館) (松山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多層カーボンナノチューブによる細胞内8-ニトログアニン生成(第2報):繊維長のDNA損傷能への影響2013

    • Author(s)
      平工雄介、Feiye Guo、馬寧、 川西正祐、村田真理子
    • Organizer
      第13回日本NO学会学術集会
    • Place of Presentation
      沖縄県医師会館 (沖縄・南風原町)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 環境因子による酸化・ニトロ化DNA損傷と発がんリスク評価2013

    • Author(s)
      平工雄介
    • Organizer
      新学術領域研究「プラズマ・ナノマテリアル動態学の創成と安全安心医療科学の構築」第11回医工連携ゼミ
    • Place of Presentation
      九州大学病院キャンパス (福岡市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Analysis of microRNA dysregulation and target genes in nasopharyngeal carcinoma (上咽頭癌におけるmicroRNA異常とターゲット遺伝子の検討)2013

    • Author(s)
      Shumin Wang, Yingxi Mo, Kaoru Midorikawa, Zhe Zhang, Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アスベスト曝露マウスの肺組織におけるマイクロRNA発現の解析2013

    • Author(s)
      平工雄介、市瀬孝道、吉田成一、定金香里、村田真理子
    • Organizer
      日本産業衛生学会東海地方会
    • Place of Presentation
      愛知医科大学(長久手市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nitrative DNA damage in lung epithelial cells exposed to multi-walled carbon nanotube2013

    • Author(s)
      Yusuke Hiraku, Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata
    • Organizer
      6th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      名古屋国際会議場 (名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多層カーボンナノチューブによるDNA損傷 : 肺上皮細胞における8-ニトログアニン生成2013

    • Author(s)
      平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube in cultured cells : a comparison with oxidative DNA damage2013

    • Author(s)
      Feiye Guo、馬寧、川西正祐、村田真理子、平工雄介
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢大学医学部(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Up-regulation of GLRX3 is associated with invasion and metastasis in nasopharyngeal carcinoma2013

    • Author(s)
      候波、莫穎禧、張哲、馬寧、平工雄介、及川伸二、翠川薫、村田真理子
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢大学医学部(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Melatonin protects against Opisthorchis viverrini-associated cholangiocarcinoma and liver injury in hamsters2013

    • Author(s)
      Umawadee Laothong、平工雄介、及川伸二、村田真理子、Somchai Pinlaor
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢大学医学部(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of dysregulated microRNA in nasopharyngeal carcinoma2013

    • Author(s)
      王淑民、莫穎禧、翠川薫、張哲、黄光武、馬寧, 平工雄介、及川伸二、村田真理子
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢大学医学部(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 多層カーボンナノチューブによる細胞内DNA損傷の解析(第2報)繊維長の影響2012

    • Author(s)
      平工雄介、Feiye Guo、村田真理子
    • Organizer
      日本産業衛生学会東海地方会
    • Place of Presentation
      じゅうろくプラザ(岐阜市)
    • Year and Date
      2012-11-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト肺組織における石綿繊維量と酸化・ニトロ化DNA損傷およびDNA修復酵素発現との関連2012

    • Author(s)
      平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 多層カーボンナノチューブによる細胞内8-ニトログアニン生成2012

    • Author(s)
      平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nitrative DNA damage in human lung tissues in association with asbestos exposure2012

    • Author(s)
      Yusuke Hiraku, Kiyoshi Sakai, Eiji Shibata, Michihiro Kamijima, Naomi Hisanaga, Ning Ma, Shosuke Kawanishi, Mariko Murata
    • Organizer
      The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh University(Edinburgh, UK)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nitrative DNA damage in human lung epithelial cells treated with multi-walled carbon nanotube2012

    • Author(s)
      Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
    • Organizer
      The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh University(Edinburgh, UK)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relation to nitrative stress2012

    • Author(s)
      Yingxi Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata
    • Organizer
      The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh University(Edinburgh, UK)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association of asbestos fiber contents with oxidative and nitrative DNA damage in human lung2012

    • Author(s)
      平工雄介、馬寧、川西正祐、村田真理子
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      ロイトン札幌 他(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube with different lengths in cultured cells2012

    • Author(s)
      Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      ロイトン札幌 他(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome-wide DNA methylation study of nasopharyngeal carcinoma in Chinese patients with Epstein-Barr virus infection2012

    • Author(s)
      Yingxi Mo, Kaoru Midorikawa, Ning Ma, Xiaoying Zhou, Guangwu Huang, Zhe Zhang, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      ロイトン札幌 他(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stromal expression of α-smooth muscle actin correlates with SDF-1 in nasopharyngeal carcinoma2012

    • Author(s)
      Shumin Wang, Ning Ma, Shosuke Kawanishi, Yusuke Hiraku, Shinji Oikawa, Ying Xie, Zhe Zhang, Guangwu Huang, Mariko Murata
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      ロイトン札幌 他(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブによる細胞内ニトロ化DNA損傷2012

    • Author(s)
      平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋観光ホテル(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] バレット食道におけるプロトンポンプ阻害剤のMn-SOD発現を介したDNA損傷への効果2012

    • Author(s)
      村田真理子、平工雄介、及川伸二、Raynoo Thanan、Somchai Pinlaor、馬寧、川西正祐
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋観光ホテル(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ビルハルツ住血吸虫感染による膀胱癌におけるDNA損傷と幹細胞マーカー2012

    • Author(s)
      大西志保、馬寧、Raynoo Thanan、小林果、平工雄介、及川伸二、村田真理子、川西正祐
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋観光ホテル(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 上咽頭癌におけるmicroRNA調節異常の検討2012

    • Author(s)
      王淑民、莫穎禧、翠川薫、張哲、黄光武、馬寧、平工雄介、及川伸二、村田真理子
    • Organizer
      第41回日本環境変異原学会
    • Place of Presentation
      グランシップ(静岡市)
    • Related Report
      2012 Annual Research Report
  • [Book] Role of nitrative DNA damage in inflammation-related carcinogenesis. In: Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects2014

    • Author(s)
      Hiraku Y, Kawanishi S
    • Total Pages
      400
    • Publisher
      Wiley
    • Related Report
      2014 Annual Research Report
  • [Book] Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects (Editors: Hiraku Y, Kawanishi S, Ohshima H)2014

    • Author(s)
      Hiraku Y, Kawanishi S
    • Total Pages
      400
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] Human Papillomavirus and Related Diseases -From Bench to Bedside- Research aspects2012

    • Author(s)
      Hiraku Y
    • Publisher
      InTech
    • Related Report
      2012 Annual Research Report
  • [Book] Biomarker2012

    • Author(s)
      Ma N, Murata M, Ohnishi S, Thanan R, Hiraku Y, Kawanishi S
    • Publisher
      InTech
    • Related Report
      2012 Annual Research Report
  • [Remarks] 三重大学大学院医学系研究科環境分子医学分野

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 三重大学医学系研究科環境分子医学分野

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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