| Project/Area Number |
24390154
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Akihito 高知大学, 教育研究部医療学系, 教授 (30191513)
HAMADA Norihiko 高知大学, 教育研究部医療学系, 講師 (50423471)
AKIRA Masanori 独立行政法人国立病院機構, (近畿中央胸部疾患センター臨床研究センター)その他部局等, その他 (20393267)
HINO Okio 順天堂大学, 医学部, 教授 (90127910)
KONDO Tadashi 独立行政法人国立がんセンター, がん研究所, 部長 (30284061)
HIROTA Ryoji 高知大学, 教育研究部医療学系, 講師 (20448385)
EITOKU Masamitsu 高知大学, 教育研究部医療学系, 助教 (50552733)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 職業性呼吸器病 / 画像診断 / 胸部エックス線 / 胸部CT / 生化学マーカー / 検診 / コホート研究 / 石綿関連疾患 / じん肺 / アスベスト / バイオマーカー / 中皮腫 |
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| Outline of Final Research Achievements |
We have reassessed current screening and surveillance strategy reviewing chest radiography, exposure history taking, biological markers and HRCT among asbestos-exposed construction workers' cohort in Fukuoka. NIOSH B-reader and Asian Intensive Readers of Pneumoconioses (AIR Pneumo) certified reader reviewed chest radiography. Prevalence of small opacities was 1.2% and that of pleural plaque was 11.6% among 2991 construction workers. Biological marker level, which is possible marker for mesothelioma, was interestingly correlated with prevalence of pleural plaques among this population. Ninty-seven HRCT scans and chest radiographs collected from similar construction workers showed more than two-fold frequencies of small opacities and pleural plaques. Further study is needed to implement International Classification of HRCT for Occupational and Environmental Respiratory Diseases, which is recommended for international studies, for the management of these exposed population.
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