Depression and interaction between occupational stress and genetic/epigenetic factors

• Project/Area Number: 24390160
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kitasato University (2015); Research Institute, International Medical Center of Japan (2012-2014)
• Principal Investigator: MIYAKI Koichi 北里大学, 医学部, 准教授 (20327498)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Tomoko 北里大学, 医学部, 助教 (60728682)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
• Keywords: メンタルヘルス / 抑うつ / ストレス / エピゲノム / 遺伝子 / 遺伝疫学 / ゲノム疫学 / 産業精神保健 / うつ / 気分障害 / 疫学 / 職域 / コホート / 栄養 / 葉酸 / 遺伝子多型

Outline of Final Research Achievements

This study was conducted in order to make the foundation of mental prevention by clarifying the interaction between occupational stress and genetic/epigenetic factors. 774 volunteers were recruited. As an epigenetic information which relates to depression, we reported the methylation proportions of BDNF gene(Am J Med Genet B 2014) and MTHFR gene(J Neurol Neurol Disord 2015) as possible useful markers. As an epigenetic information which relates to occupational stress, we reported the methylation proportions of TH gene(J Neurol Neurol Disord 2015) as a possible useful marker.

Research Products

• [Journal Article] DNA Methylation Status of the Methylenetetrahydrofolate Reductase Gene is associated with Depressive Symptoms in Japanese Workers: A Cross-Sectional Study. (2015)
  • Author(s): Miyaki K, Song Y, Suzuki T, Eguchi H, Kawakami N, Takahashi M, Shimazu A, Inoue A, Kurioka S, Kan C and Tsutsumi A.
  • Journal Title: J Neurol Neurol Disord Volume: 2(3) Pages: 304-304
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epigenetic Changes Caused by Occupational Stress in Humans Revealed through Noninvasive Assessment of DNA Methylation of the Tyrosine Hydroxylase Gene. (2015)
  • Author(s): Miyaki K, Suzuki T, Song Y, Tsutsumi A, Kawakami N, Shimazu A, Takahashi M, Inoue A, Kurioka S, Shimbo T.
  • Journal Title: J Neurol Neurol Disord Volume: 2(2) Issue: 2 Pages: 201-201
  • DOI: 10.15744/2454-4981.2.201
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered DNA methylation status of human brain derived neurotrophis factor gene could be useful as biomarker of depression. (2014)
  • Author(s): Song Y, Miyaki K, Suzuki T, Sasaki Y, Tsutsumi A, Kawakami N, Shimazu A, Takahashi M, Inoue A, Kan C, Kurioka S, Shimbo T.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. Volume: 165 Issue: 4 Pages: 357-64
  • DOI: 10.1002/ajmg.b.32238
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered DNA Methylation Status of Human Brain Derived Neurotrophis Factor Gene Could Be Useful as Biomarker of Depression (2014)
  • Author(s): Yixuan Song, Koichi Miyaki, Tomoko Suzuki, Yasuharu Sasaki, Akizumi Tsutsumi, Norito Kawakami, Akihito Shimazu, Masaya Takahashi, Akiomi Inoue, Chiemi Kan, Sumiko Kurioka, Takuro Shimbo
  • Journal Title: Neuropsychiatric Genetics Volume: 未定
  • Peer Reviewed
• [Journal Article] Socioeconomic status is significantly associated with the dietary intakes of folate and depression scales in Japanese workers (2013)
  • Author(s): Miyaki K, et al.
  • Journal Title: Nutrients Volume: 5 Issue: 2 Pages: 565-578
  • DOI: 10.3390/nu5020565
  • Peer Reviewed
• [Journal Article] Socioeconomic status is significantly associated with dietary salt intakes and blood pressure in Japanese workers (2013)
  • Author(s): Miyaki K, et al.
  • Journal Title: Int J Environ Res Public Health Volume: 10 Issue: 3 Pages: 980-993
  • DOI: 10.3390/ijerph10030980
  • Peer Reviewed
• [Journal Article] Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors : J-HOPE study (2012)
  • Author(s): Miyaki K, et al.
  • Journal Title: BMC Psychiatry Volume: 20 Issue: 1 Pages: 12-33
  • DOI: 10.1186/1471-244x-12-33
  • Peer Reviewed
• [Presentation] 日本食パターンのうつ症状への効果と仕事のストレス因子による影響 (2013)
  • Author(s): 宮木幸一, ら
  • Organizer: 日本疫学会
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-01-24