Study of the long-term trends of cardiovascular diseases from the population-based registry and the change of magnitude of risk factors from the cohort study: Takashima Study

• Project/Area Number: 24390165
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Tsuruga Nursing University (2014-2015); Shiga University of Medical Science (2012-2013)
• Principal Investigator: KITA YOSHIKUNI 敦賀市立看護大学, 看護学部, 准教授 (30147524)
• Co-Investigator(Kenkyū-buntansha): MATSUI KENJI 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 室長 (60431764) ; UESHIMA HIROTSUGU 滋賀医科大学, 生活習慣病予防センター, 特任教授 (70144483) ; TAKASHIMA NAOYUKI 滋賀医科大学, 生活習慣病予防センター, 特任助教 (80435883) ; MIURA KATSUYUKI 滋賀医科大学, 社会医学講座公衆衛生学部門, 教授 (90257452)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 生活習慣病 / 発症登録 / コホート研究 / 発症要因 / 長期推移 / 遺伝子解析

Outline of Final Research Achievements

We conducted a registration of cardiovascular diseases and cohort study in Takashima, Shiga to clarify the change in onset of cardiovascular diseases and risk factors. In the registration of cardiovascular diseases, crude incidence rate of stroke among both of men and women increased as a reflection of the increase in aging in the same area. Whereas, the crude incidence rate of acute myocardial infarction reached a peak in 2000, and then declined in both men and women. The results of the cohort study showed that aging, increase of blood pressure and HbA1c, and progression of arteriosclerosis by baPWV were due to the positive conversion of urine microalbumin. Results of the studies targeting general population also clarified that the progression of arteriosclerosis evaluated by baPWV significantly increased the risk of onset of cardiovascular disease.

Research Products

• [Int'l Joint Research] Vanderbilt University School of Medicine(米国)
• [Int'l Joint Research] Queen Mary University of London(英国)
• [Journal Article] Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. (2016)
  • Author(s): W. Wen (他75名, 山本55番目)
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 17958-17958
  • DOI: 10.1038/srep17958
  • NAID: 120005822753
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. (2016)
  • Author(s): Pattaro C, Teumer A, Gorski M, et al.
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 10023-10023
  • DOI: 10.1038/ncomms10023
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Acute-onset atrial fibrillation and ambient air temperature: a linear or a non-linear association? (2015)
  • Author(s): Chowdhury Turin T, Kita Y, Rumana N.
  • Journal Title: J Epidemiol Glob Health Volume: 5(1) Issue: 1 Pages: 99-101
  • DOI: 10.1016/j.jegh.2014.09.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. (2015)
  • Author(s): Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Ohkubo T, Takashima N, Miki T, et al.
  • Journal Title: Diabetes Volume: 64 Issue: 1 Pages: 291-298
  • DOI: 10.2337/db14-0563
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population. (2014)
  • Author(s): Hara M, Nakamura K, Nanri H, Nishida Y, Hishida A, Kawai S, Hamajima N, Kita Y, Suzuki S, Mantjoro EM, Ohnaka K, Uemura H, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.
  • Journal Title: J Epidemiol Volume: 24(5) Pages: 379-384
  • NAID: 130004449419
  • Peer Reviewed
• [Journal Article] Acute case-fatality rates of stroke and acute myocardial infarction in a Japanese population: Takashima stroke and AMI registry, 1989-2005. (2014)
  • Author(s): Rumana N, Kita Y, Turin TC, Nakamura Y, Takashima N, Ichikawa M, Sugihara H, Morita Y, Hirose K, Kawakami K, Okayama A, Miura K, Ueshima H.
  • Journal Title: Int J Stroke Volume: Supple A100 Issue: SA100 Pages: 69-75
  • DOI: 10.1111/ijs.12288
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Combining the effects of conventional risk factors and environmental triggering factors while studying seasonality in acute myocardial infarction. (2014)
  • Author(s): Al Mamun M, Rumana N, Kita Y, Turin TC.
  • Journal Title: Environ Pollut Volume: 189 Pages: 252-253
  • DOI: 10.1016/j.envpol.2014.03.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The relationship of brachial-ankle pulse wave velocity to future cardiovascular disease events in the general Japanese population: the Takashima Study. (2014)
  • Author(s): Takashima N, Turin TC, Matsui K, Rumana N, Nakamura Y, Kadota A, Saito Y, Sugihara H, Morita Y, Ichikawa M, Hirose K, Kawakani K, Hamajima N, Miura K, Ueshima H, Kita Y.
  • Journal Title: J Hum Hypertens Volume: 28(5) Issue: 5 Pages: 323-327
  • DOI: 10.1038/jhh.2013.103
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. (2014)
  • Author(s): Chen P, Takeuchi F, Lee JY,.., Kita Y, et al
  • Journal Title: Diabetes Volume: 63(7) Issue: 7 Pages: 2551-2562
  • DOI: 10.2337/db13-1815
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study. (2014)
  • Author(s): Hishida A, Takashima N, Turin TC, Kawai S, Wakai K, Hamajima N, Hosono S, Nishida Y, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Matsui D, Katsuura-Kamano S, Kubo M, Tanaka H, Kita Y.
  • Journal Title: J Nephrol Volume: 27(2) Issue: 2 Pages: 143-149
  • DOI: 10.1007/s40620-013-0025-0
  • Peer Reviewed
• [Journal Article] Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. (2013)
  • Author(s): Kelly TN, Takeuchi F, Tabara Y, et al.
  • Journal Title: Hypertension. Volume: 62 Issue: 5 Pages: 853-859
  • DOI: 10.1161/hypertensionaha.113.01148
  • Peer Reviewed
• [Journal Article] Wake-up stroke: incidence, risk factors and outcome of acute stroke during sleep in a Japanese population. Takashima Stroke Registry 1988-2003. (2013)
  • Author(s): Turin TC, Kita Y, Rumana N, Nakamura Y, Takashima N, Ichikawa M, Sugihara H, Morita Y, Hirose K, Okayama A, Miura K, Ueshima H.
  • Journal Title: Eur Neurol. Volume: 69(6) Issue: 6 Pages: 354-359
  • DOI: 10.1159/000346124
  • Peer Reviewed
• [Journal Article] Wake-Up Stroke : Incidence, Risk Factors and Outcome of Acute Stroke during Sleep in a Japanese Population. Takashima Stroke Registry 1988-2003. (2013)
  • Author(s): Turin TC, Kita Y, Rumana N, Nakamura Y, Takashima N, Ichikawa M, Sugihara H, Morita Y, Hirose K, Okayama A, Miura K, Ueshima H.
  • Journal Title: Eur Neurol. Volume: 25 Pages: 354-359
  • Peer Reviewed
• [Journal Article] Hunting for genes for hypertension: the Millennium Genome Project for Hypertension. (2012)
  • Author(s): Tabara Y
  • Journal Title: Hypertens Res Volume: 35 Issue: 6 Pages: 567-573
  • DOI: 10.1038/hr.2012.41
  • Peer Reviewed
• [Journal Article] Ambient air pollutants and acute case-fatality of cerebro-cardiovascular events : Takashima Stroke and AMI Registry, Japan (1988-2004). (2012)
  • Author(s): Turin TC, Kita Y, Rumana N, Nakamura Y Ueda K, Takashima N, Sugihara H, Morita Y Ichikawa M, Hirose K, Nitta H, Okayama A, Miura K, Ueshima H.
  • Journal Title: Cerebrovasc Dis. Volume: 34 Issue: 2 Pages: 130-139
  • DOI: 10.1159/000339680
  • Peer Reviewed
• [Journal Article] A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval (2012)
  • Author(s): Kim JW, Hong KW, Go MJ, Kim SS, Tabara Y, Kita Y, Tanigawa T, Cho YS, Han BG, Oh B
  • Journal Title: Am J Hum Genet Volume: 91 Issue: 1 Pages: 180-184
  • DOI: 10.1016/j.ajhg.2012.05.019
  • Peer Reviewed
• [Patent(Industrial Property Rights)] 高血圧感受性遺伝子群の同定 (2013)
  • Inventor(s): 三木哲郎、田原康玄、・・、喜多義邦、他
  • Industrial Property Rights Holder: 三木哲郎、田原康玄、・・、喜多義邦、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-19
  • Acquisition Date: 2014-10-29
  • Overseas