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Molecular epidemiological study on oxidative stress and type 2 diabetes mellitus in a population-based cohort

Research Project

Project/Area Number 24390166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKyushu University

Principal Investigator

OHNAKA KEIZO  九州大学, 医学(系)研究科(研究院), 講師 (30325518)

Co-Investigator(Kenkyū-buntansha) TAKAYANAGI Ryoichi  九州大学, 大学院医学研究院, 教授 (30154917)
YAMAMOTO Ken  九州大学, 生体防御医学研究所, 准教授 (60274528)
KONO Suminori  九州大学, 大学院医学研究院, 教授 (70128015)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsoxidative stress / type 2 diabetes mellitus / population-based cohort / molecular epidemiology / 酸化ストレス / 2型糖尿病 / 住民コホート / 分子疫学 / 2型糖尿病
Outline of Final Research Achievements

We prospectively investigated the association between type 2 diabetes mellitus (T2DM) and gene polymorphisms related with oxidative stress, such as bilirubin-metabolizing enzymes or anti-oxidative enzymes, in a community-based cohort study. No significant association was observed between the incidence of T2DM and serum bilirubin or single nucleotide polymorphisms (SNPs) of UGT1A1, HMOX1, but one SNP examined among the genes of anti-oxidative enzymes was associated with the incidence of T2DM. Several SNPs reported in previous genome-wide association studies (GWAS) have also significant association with the incidence of T2DM in this cohort study. Intake of rice was positively related with the incidence of T2DM, while consumption of green tea was related negatively, especially in women. Intake of green tea reported to have anti-oxidative effect may be protective for the increased risk of T2DM with higher intake of rice.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (6 results)

  • [Journal Article] A dietary pattern characterized by a high consumption of vegetables and fruits is related to lower concentrations of serum bilirubin in Japanese women2014

    • Author(s)
      Hirata A, Ohnaka K, Tanaka M, Wang Z, Morita M, Toyomura K, Kono S, Takayanagi R
    • Journal Title

      J Endocrinol Diabetes Obes

      Volume: 2(1) Pages: 1013-1013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians2014

    • Author(s)
      Chen P, Takeuchi F, Lee JY,.., Kita Y, et al
    • Journal Title

      Diabetes

      Volume: 63 Issue: 7 Pages: 2551

    • DOI

      10.2337/db13-1815

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Coffee consumption, serum γ-glutamyltransferase, and glucose tolerance status in middle-aged Japanese men2013

    • Author(s)
      Hiramatsu T, et al.
    • Journal Title

      Clin Chem Lab Med

      Volume: 51 Issue: 6 Pages: 1233-1239

    • DOI

      10.1515/cclm-2012-0700

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary polyphenols and colorectal cancer risk: the Fukuoka colorectal cancer study2013

    • Author(s)
      Wang ZJ, et al.
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 17 Pages: 2683-2690

    • DOI

      10.3748/wjg.v19.i17.2683

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men2013

    • Author(s)
      Hamachi T, et al.
    • Journal Title

      BMC Endocr Disord

      Volume: 19 Issue: 25 Pages: 4023-4030

    • DOI

      10.3748/wjg.v19.i25.4023

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women2013

    • Author(s)
      Tanaka M, Budhathoki S, Hirata A, Morita M, Kono S, Adachi M, Kawate H, Ohnaka K, Takayanagi R
    • Journal Title

      BMC Endocr Disord

      Volume: 13(1) Issue: 1 Pages: 39-39

    • DOI

      10.1186/1472-6823-13-39

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women2012

    • Author(s)
      Hirata A, Ohnaka K, Morita M, Toyomura K, Kono S, Yamamoto K, Adachi M, Kawate H, Takayanagi R
    • Journal Title

      Clin Chem Lab Med

      Volume: 50(8) Issue: 8 Pages: 1469-1476

    • DOI

      10.1515/cclm-2011-0839

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No effect modification of scrum bilirubin or coffee consumption on the association of gamma-glutamyltransferase with glycated hemoglobin in a cross-sectional study of Japanese men and women2012

    • Author(s)
      Wang Z, et al.
    • Journal Title

      BMC Endocr Disord

      Volume: 12 Issue: 1 Pages: 24-24

    • DOI

      10.1186/1472-6823-12-24

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 九州大学福岡コホート研究2012

    • Author(s)
      大中佳三、他
    • Journal Title

      日本内科学会雑誌

      Volume: 101 Pages: 1141-1144

    • NAID

      10030748931

    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム「老年病のコホート研究」-地域住民コホートと老年病研究2014

    • Author(s)
      大中佳三
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中・高年の地域一般住民における疾患感受性遺伝子による2型糖尿病発症予測の検討2014

    • Author(s)
      大中佳三、河野倫子、河手久弥、野村政壽、井口登與志、髙栁涼一
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 疾患感受性遺伝子による2型糖尿病発症予測の検討2014

    • Author(s)
      大中佳三、河野倫子、山本健、河手久弥、野村政壽、古野純典、井口登與志、高柳涼一
    • Organizer
      第87回日本内分泌学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中高年者における食事習慣と味覚受容体遺伝子多型の関連に関する研究2013

    • Author(s)
      大中佳三、他
    • Organizer
      第55回日本老年医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] A randomized controlled trial of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in overweight men2013

    • Author(s)
      Keizo Ohnaka, et al.
    • Organizer
      95th Annual Meeting of the Endocrine Society
    • Place of Presentation
      SanFrancisco, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dietary soft drinks, sweetened food, added sugar and colorectal cancer risk : The Fukuoka Colorectal Cancer Study2012

    • Author(s)
      Wang Z, et al.
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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